Hodgkin Lymphoma

Yıl 2024, Cilt: 3 Sayı: 1, 28 - 36, 30.03.2024

Nergiz Erkut

https://doi.org/10.59518/farabimedj.1325315

Öz

Hodgkin lymphoma (HL) is a rare malignant neoplasm of the lymphatic system. It accounts for approximately 10% of all lymphomas. Although it is frequently observed in young people, it is observed less frequently in the elderly. HL is a malignancy that originates from the germinal center B lymphocytes and is characterized by a marked increase in inflammatory cells in the tumoral microenvironment. There are two types, classical HL and nodular lymphocyte-predominant HL (NLPHL), which have different clinical and pathological features. Classical HL accounts for 90-95%, and NLPHL 5-10% of cases. Approximately 80% of patients are cured with chemotherapy and/or radiotherapy. This review will focus on the epidemiology, etiology, pathobiology, clinic, diagnosis and treatment of HL.

Anahtar Kelimeler

Clinic, Diagnosis, Hodgkin lymphoma, Treatment

Hodgkin Lenfoma

Öz

Hodgkin lenfoma (HL), lenfatik sistemin nadir görülen malign bir neoplazisidir. Tüm lenfomaların yaklaşık %10’unu oluşturmaktadır. Sıklıkla gençlerde izlenmekle birlikte, daha az oranda yaşlılarda da gözlenmektedir. HL, germinal merkez B lenfositlerden kaynaklanan ve tümöral mikroçevrede belirgin inflamatuvar hücre artışı ile karakterize bir malignensidir. Klinik ve patolojik özellikleri farklı olan klasik HL ve nodüler lenfosit-predominant HL (NLPHL) olmak üzere iki tipi mevcuttur. Klasik HL vakaların %90-%95’ini, NLPHL ise %5-10’unu oluşturmaktadır. Kemoterapi ve/veya radyoterapi ile hastaların yaklaşık %80’inde kür sağlanmaktadır. Bu derlemede HL’nin epidemiyoloji, etiyoloji, patobiyoloji, klinik, tanı ve tedavisi üzerinde durulacaktır.

Anahtar Kelimeler

Hodgkin lenfoma, Klinik, Tanı, Tedavi

Destekleyen Kurum

Hayır

Kaynakça

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