Önemli Bir Adipokin: İstmin-1

Yıl 2025, Cilt: 4 Sayı: 1, 12 - 16, 30.03.2025

Kawther Ameen Muhammed Saeed Aledresi , Birgül Kural , Sevil Kör

https://doi.org/10.59518/farabimedj.1572593

Öz

İsthmin-1'in farklı vücut bölmelerinde bulunması metabolizma, hücre çoğalması, endotel geçirgenliği, anjiyogenez ve immünitedeki önemini ortaya koymaktadır. Çalışmalar isthmin-1'i, adipositler tarafından glukozu alan ve bilinmeyen bir reseptör aracılığıyla karaciğer yağlanmasını engelleyen insülin benzeri davranışa sahip bir adipokin olarak kategorize etmiştir. Ek olarak, bu adipokin organ gelişimini ve homeostazisini düzenlemede önemli işlevler göstermektedir. Bu derleme, isthmin-1 proteininin esas olarak glukoz ve lipid metabolizmaları üzerindeki işlevleri hakkındaki bilgileri özetlemeyi amaçlamaktadır.

Anahtar Kelimeler

Adipokin, Glukoz ve lipid metabolizması, İstmin-1

Etik Beyan

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Destekleyen Kurum

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Teşekkür

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An Important Adipokine: Isthmin-1

Öz

The presence of isthmin-1 in different body compartments reveals its significance in metabolism, cell proliferation, endothelial permeability, angiogenesis and immunity. Studies have categorized isthmin-1 as an adipokine with insulin-like behavior that uptakes glucose by the adipocytes and inhibits liver steatosis through a not identified tyrosine kinase receptor, that it is distinct from insulin receptor. Additionally, this adipokine demonstrates important functions in regulating organs development and homeostasis. This review aims to summarize the informations of isthmin-1 protein mainly its functions on glucose and lipid metabolisms.

Anahtar Kelimeler

Adipokine, Glucose and lipid metabolism, Isthmin-1

Kaynakça

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