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A general overview to physiological and morphological changes and developments

Yıl 2009, Cilt: 15 Sayı: 2, 56 - 65, 01.03.2009

Öz

Presbycusis (age-related hearing loss) is one of the principal communicative and chronic medical disorders of our aged population. Preventative and curative biomedical interventions provide us with an understanding of the basis of this neural and molecular sensory deficit. The cochlear nucleus (CN) receives the outputs of the auditory portion of the inner ear, and sends these outputs to the centres where critical sound and perception analyses are conducted in parallel processing pathways of brainstem. This location plays a key role to process the sound. This location is an important place to investigate the structural and functional changes related to aging occuring in cochlear nucleus. Our goal is to reveal the neurophysiologic bases of functional changes which occur in mammalian CN related to aging.

Kaynakça

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  • 2.Syka J. Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning. Physiol Rev. 2002;82:601-636
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  • 9.Frisina RD, Walton JP. Age-related structural and functional changes in the cochlear nucleus. Hear Res. 2006;216-217:216-223
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Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış

Yıl 2009, Cilt: 15 Sayı: 2, 56 - 65, 01.03.2009

Öz

Presbikuzi (yaşlanmaya bağlı olarak işitme gücünün azalması); yaşlanmış insanlarımızın başta gelen iletişimsel ve kronik tıbbi bozukluğudur. Önleyici ve iyileştirici biyomedikal girişimler sadece, bu duyu kaybının sinirsel ve moleküler temelini anlamamızı sağlar. Koklear nukleus (KN); iç kulağın, işitme duyusuna ait kısmının çıktılarını alır ve beyin sapındaki paralel işleme yollarında kritik ses analizi ve algılama yapılan merkezlere aktarır. Sesin işleme tabi tutulması için bu bölge, anahtar bir rol oynar. Bu bölge yaşlanmaya bağlı olarak KN'de meydana gelen yapısal ve fonksiyonel değişiklikleri incelemek için önemli bir yerdir. Amacımız, memeli KN'sinde yaşlanmaya bağlı olarak meydana gelen fonksiyonel değişikliklerin nörofizyolojik temellerini ortaya koymaktır.

Kaynakça

  • l.Willott JF, Parham K, Hunter KP. Comparison of the auditory sensitivity of neurons in the cochlear nucleus and inferior colliculus of young and aging C57BL/6J and CBA/J mice. Hear Res. 1991;53:78-94
  • 2.Syka J. Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning. Physiol Rev. 2002;82:601-636
  • 3.Thomas A, Herbst KG Social and psychological implications of acquired deafness for adults of employment age. Br J Audiol. 1980;14:76-85
  • 4.Weinstein BE, Ventry IM. Hearing impairment and social isolation in the elderly. J Speech Hear Res. 1982;25:593-599
  • 5.Mulrow CD, Aguilar C, Endicott JE, Tuley MR, Velez R, Charlip WS, et al. Quality-of-life changes and hearing impairment: a randomized trial. Ann Intern Med. 1990;113:188-194
  • 6.Gordon-Salant S, Fitzgibbons PJ. Temporal factors and speech recognition performance in young and elderly listeners. J Speech Hear Res. 1993;36:1276-1285
  • 7.Frisina DR, Frisina RD. Speech recognition in noise and presbycusis: relations to possible neural mechanisms. Hear Res. 1997; 106:95-104
  • 8.Caspary DM, Schatteman TA, Hughes LF. Age-Related Changes in the Inhibitory Response Properties of Dorsal Cochlear Nucleus Output Neurons: Role of Inhibitory Inputs. The J Neurosci. 2005;25(47): 10952-10959
  • 9.Frisina RD, Walton JP. Age-related structural and functional changes in the cochlear nucleus. Hear Res. 2006;216-217:216-223
  • lO.Schuknecht H. Pathology of the ear. Cambridge, MA, Harward University Press, 1974;388-403
  • ll.Schuknecht HF. Pathology of presbycusis. In, Goldstein JC, Kashima, HK and Koopman CF (eds), Geriatric Otorhinolaryngology. Inc., Toronto and Philadelphia, BD Decker, 1989;40-44
  • 12.Schuknecht HF, Gacek MR. Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol. 1993;102:l-16
  • 13.Liu XZ, Yan D. Ageing and hearing loss. J Pathol. 2007;21:188-197
  • 14.Arnesen AR. Presbycusis - loss of neurons in the human cochlear nuclei. J Laryngol Otol. 1982;96:503-511
  • 15.Welsh LW, Welsh JJ, Healy MP. Central presbycusis. The Laryngol. 1985;95:128-136
  • 16.Willott JF, Bross LS, McFadden SL Morphology of the dorsal cochlear nucleus in C57BL/6J and CBA/J mice across the life span. J Comp Neurol. 1992;32:666-678
  • 17.Hawkins JE, Miller JM, Rouse RC, Davis JA, Rarey K. Inner ear histopathology in aging rhesus monkeys (Maçaca mulatta). In, Davis RT and Leathers CW (eds) Behavior and Pathology of Aging in Rhesus Monkeys. Alan R. Liss, Inc., New York. 1985; 137-154
  • 18.Dayal VS, Bhattacharyya TK. Comparative study of age-related cochlear hair cell loss. Ann Otol Rhinol Laryngol. 1986;95:510-513
  • 19.Henry KR, Chole RA. Genotypic differences in behavioral, physiological and anatomical expressions of age-related hearing loss in the laboratory mouse. Audiology. 1980; 19:369-383
  • 2O.Keithley EM,Feldman ML. Hair cell counts in an age-graded series of rat cochleas. Hear Res. 1982;8:249-262
  • 21.Bhattacharyya TK, Dayal VS. Age-related cochlear hair cell loss in the chinchilla. Ann Otol Rhinol Laryngol. 1985;94:75-80
  • 22.Bonne BA, Gruner MM, Harding GW. Morphological correlates of aging in the chinchilla cochlea. Hear Res. 1990;48:79-92
  • 23.Bhattacharyya TK, Dayal VS. Influence of age on hair cell loss in the rabbit cochlea. Hear Res. 1989;40:179-184
  • 24.Coleman JW. Hair cell loss as a function of age in the normal cochlea of the guniea pig. Acta Otolaryngol. 1976;82:33-40
  • 25.Shimada A, Ebisu M, Morita T, Takeuchi T, Umemura T. Age-Related Changes in the Inhibitory Response Properties of Dorsal Cochlear Nucleus Output Neurons: Role of Inhibitory Inputs. J Vet Med Sci. 1998;60(l):41-48
  • 26.Dubno JR, Dirks DD, Morgan DE. Effects of age and mild hearing loss on speech recognition in noise. J Acoust Soc Am. 1984;76:87-96
  • 27.Moore BC, Peters RW, Glasberg BR. Detection of temporal gaps in sinusoids by elderly subjects with and without hearing loss. J Acoust Soc Am. 1992;92:1923-1932
  • 28.Fitzgibbons PJ, Gordon-Salant S. Age effects on measures of auditory duration discrimination. J Speech Hear Res. 1994;37:662-670
  • 29.Schneider BA, Pichora-Fuller MK, Kowalchuk D, Lamb M. Gap detection and the precedence effect in young and old adults. J Acoust Soc Am. 1994;95:980-991
  • 30-Snell KB. Age-related changes in temporal gap detection. J Acöust Soc Am. 1997;101:2214-2220
  • 31.Strouse A, Ashmead DH, Ohde RN, Grantham DW. Temporal processing in the aging auditory system. J Acoust Soc Am. 1998; 104:2385-2399
  • 32.Tremblay KL, Piskosz M, Souza P. Aging alters the neural representation of speech cues. Neuro Report. 2002; 13:1865-1870
  • 33.Tremblay KL, Piskosz M, Souza P. Effects of age and age-related hearing loss on the neural representation of speech cues. Clin Neurophysiol. 2003;114:1332-1343
  • 34.Ostroff JM, McDonald KL, Schneider BA, Alain C. Aging and the processing of sound duration in human auditory cortex. Hear Res. 2003; 181:1-7
  • 35.Caspary DM, Raza A, Lawhorn Armour BA, Pippin J, Arneric SP. Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis. J Neurosci. 1990;10:2363-2372
  • 36.Caspary DM, Backoff PM, Finlayson PG, Palombi PS. Inhibitory inputs modulate discharge rate within frequency receptive fields of anteroventral cochlear nucleus. J Neurophysiol. 1994;72:2124-2133
  • 37.Caspary DM, Milbrandt JC, Helfert RH. Central auditory aging: GABA changes in the inferior colliculus. Exp Gerontol. 1995;30:349-360
  • 38.Schmolesky MT, Wang Y, Pu M, Leventhal AG. Degradation of stimulus selectivity of visual cortical cells in senescent rhesus monkeys. Nat Neurosci. 2000;3:384-390
  • 39.Caspary DM, Salvi PJ, Helfert RH, Brozoski TJ, Bauer CA. Neuropharmacology of noise induced hearing loss in brainstem auditory structures. In: Noise induced hearing loss: mechanisms of damage and means of prevention. Henderson D, Prasher D, Kopke R, Salvi RJ, Hamernik R. (eds), London: NRN. 2001;169-186
  • 40.Mendelson JR, Ricketts C. Age-related temporal processing speed deterioration in auditory cortex. Hear Res. 2001; 158:84-94
  • 41.Caspary DM, Palombi PS, Hughes LF. GABAergic inputs shape responses to amplitude modulated stimuli in the inferior colliculus. Hear Res. 2002;168:163-173
  • 42.Leventhal AG, Wang Y, Pu M, Zhou Y, Ma Y. GABA and its agonists improved visual cortical function in senescent monkeys. Hear Res. 2003;300:812-815
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  • 56.Zheng QY, Johnson KR, Erway LC. Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. Hear Res. 2001; 154:45-53
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  • 60.Ohlemiller KK, McFadden SL, Ding DL, Lear PMI, Ho YS. Targeted mutation of the gene for cellular glutathione peroxidase (Gpxl) increases noise-induced hearing loss in mice. Assoc Res Otolaryngol. 2000; 1:243-254
  • 61.McFadden SL, Ohlemiller KK, Ding D, Shero M, Salvi RJ. The influence of superoxide dismutase and glutathione peroxidase deficiencies on noise-induced hearing loss in mice. Noise Health. 2001;3:49-64
  • 62.Fortunato G, Marciano E, Zarrilli F, Mazzaccara C, Intrieri M, Calcagno G, et al. Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. Clin Chem. 2004;50:2012-2018
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  • 64.Wang Y, Manis PB. Synaptic transmission at the cochlear nucleus end bulb synapse during age-related hearing loss in mice. J Neurophysiol. 2005;94:1814-1824
  • 65.Walton JP, Frisina RD, Ison JE, O'Neill WE. Neural correlates of behavioral gap detection in the inferior colliculus of the young CBA mouse. J Comp Physiol A. 1997;181:161-176
  • 66.Walton JP, Frisina RD, O'Neill WE. Age-related alteration in neural processing of silent gaps in the central nucleus of the inferior colliculus in the CBA mouse model of presbycusis. J Neurosci. 1998;18:2764-2776
  • 67.Allen PD, Burkard RF, Ison JR, Walton JP. Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levels. Hear Res. 2003; 186:17-29
  • 68.Frisina RD. Possible neurochemical and neuroanatomical bases of age-related hearing loss -presbycusis. Sem. Hearing: Innovations in Aging Auditory Res. 2001a;22:213-225
  • 69.Frisina RD. Anatomical and neurochemical bases of presbycusis. In: Hof PR, Mobbs CV. (eds.), Functional Neurobiology of Aging . Academic Press, San Diego, 2001b;531-547
  • 7O.Frisina, DR, Frisina RD, Snell KB, Burkard R, Walton JP, Ison JR. Auditory temporal processing during aging. In: Hof PR, Mobbs CV. (eds.), Functional Neurobiology of Aging (Chapter 39). Academic Press, San Diego, 2001;565-579
  • 71.Willott JF, Bross LS. Morphological changes in the anteroventral cochiear nucleus that accompany sensorineural hearing loss in DBA/2J and C57BL/6J mice. Dev Brain Res. 1996;91:218-226
  • 72.Briner W, Willott JF. Ultrastructural features of neurons in the CB57BL/6J mouse anteroventral cochiear nucleus: young mice versus old mice with chronic presbycusis. Neurobiol Aging. 1989;10:295-303
  • 73.Willott JF, Bross LS. Morphology of the octopus cell area of the cochiear nucleus in young and aging C57BL/6J and CBA/J mice. J Comp Neurol. 1990;300:61-81
  • 74.Willott JF, Bross LS, McFadden SL. Morphology of the cochiear in CBA/J mice with chronic, severe sensorineural cochiear pathology induced during adulthood. Hear Res. 1994;74:1-21
  • 75.Voigt HF, Young ED. Evidence of inhibitory interactions between neurons in dorsal cochiear nucleus. J Neurophysiol. 1980;44:76-96
  • 76.Caspary DM, Pazara KE, Kossl M, Faingold CL. Strychnine alters the fusiform cell output from the dorsal cochiear nucleus. Brain Res. 1987;417:273-282
  • 77.Davis KA, Young ED. Pharmacological evidence of inhibitory and disinhibitory neuronal circuits in dorsal cochiear nucleus. J Neurophysiol. 2000;83:926-940
  • 78.Young ED, Oertel D. Cochiear nucleus. In: The synaptic organization of the brain. Shepherd GM. (ed), New York, Oxford UP. 2004; 125-163
  • 79.Gibson DJ, Young ED, Costalupes JA. Similarity of dynamic range adjustment in auditory nerve and cochiear nuclei. J Neurophysiol. 1985;53:940-958
  • 80.Frisina RD, Walton JP, Karcich KJ. Dorsal cochiear nucleus single neurons can enhance temporal processing capabilities in background noise. Exp Brain Res. 1994; 102:160-164
  • 81.Rhode WS, Greenberg S. Encoding of amplitude modulation in the cochiear nucleus of the cat. J Neurophysiol. 1994;71:1797-1825
  • 82.Joris PX, Schreiner CE, Rees A. Neural processing of amplitude modulated sounds. Physiol Rev. 2003;84:541-577
  • 83.Frisina RD, Walton JP. Aging of the mouse central auditory system. In: Willott JP. (ed.), Handbook of Mouse Auditory Research: From Behavior to Molecular Biology (Chapter 24), New York, CRC Press, 2001;339-379
  • 84.Keithley EM, Croskrey KL. Spiral ganglion cell endings in the cochiear nucleus of young and old rats. Heal' Res. 1990;49:169-177
  • 85.Helfert RD,' Krenning J, Wilson TS, Hughes LF. Age-related synaptic changes in the anteroventral cochiear nucleus of Fischer-344 rats. Hear Res. 2003; 183:18-28
  • 86.Helfert RD, Sommer TJ, Meeks J, Hofstetter P, Hughes LF. Age-related synaptic changes in the central nucleus of the inferior colliculus of the Fischer-344 rat. J Comp Neurol. 1999;406:285-298
  • 87.Milbrandt JC, Caspary DM. Age-related reduction of [3H]strychnine binding sites in the cochiear nucleus of the Fischer 344 rat. Neurosci. 1995;67:713-719
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  • 89.Willott JF, Milbrandt JC, Bross LS, Caspary DM. Glycine immunoreactivity and receptor binding in the cochiear nucleus of C57BL/6J and CBA/CaJ mice: effects of cochiear impairment and aging. J Comp Neurol. 1997;385:405-414
  • 9O.Raza A, Milbrandt JC, Arneric SP, Caspary DM. Agerelated changes in brainstem auditory neurotransmitters: measures of GABA and acetylcholine functions. Hear Res. 1994;77:221-230
  • 91.Banay - Schwartz M, Lajtha A, Palovits M. Changes with aging in the levels of amino acids in rat CNS structural elements I. Glutamate and related amino acids. Neurochem Res. 1989; 14:555-562
  • 92.Frisina RD, Rajan R. Inferior colliculus: aging and plasticity. In: Winer J, Schreiner C. (eds.), The Inferior Colliculus (Chapter 18). New York, Springer, 2005;559-584
  • 93.Saitoh Y, Hosokawa M, Shimada A, Watanabe Y, Yasuda N, Takeda T, et al. Age-related hearing impairment in senescence - accelerated mouse (SAM). Hear Res. 1994;75:27-37
  • 94.Gratton MA, Schmiedt RA, Schulte BA. Age-related decreases in endocochlear potential are associated with vascular abnormalities in the stria vascularis. Hear Res. 1996; 102:181-190
  • 95.Gratton MA, Schulte BA, Smythe NM. Quantification of the stria vascularis and strial capillary areas in quiet-reared young and aged gerbils. Hear Res. 1997; 114:1-9
  • 96.Spongr VP, Flood DG, Frisina RD, Salvi RJ. Quantitative measures of hair cell loss in CBA and C57BL/6 mice throughout their life spans. J Acoust Soc Am. 1997;101:3546-3553
  • 97.1ngham NJ, Comis SD, Withington DJ. Hair cell loss in the aged guinea pig cochlea. Acta Otolaryngol. 1999; 119:42-47
  • 98.Tumer JG, Caspary DM. Comparison of two rat models of aging. In: Plasticity and signal representation in the auditory system. Syka J, Merzenich MM. (eds), New York, Springer, 2005;217-225
  • 99.Keithley EM, Ryan AF, Woolf NK. Spiral ganglion cell density in young and old gerbils. Hear Res. 1989;38:125-133
  • lOO.Keithley EM, Ryan AF, Feldman ML. Cochlear degeneration in aged rats of four strains. Hear Res. 1992;59:171-178
  • lOl.Dazert S, Feldman ML, Keithley EM. Cochlear spiral ganglion cell degeneration in wild-caught.mice as a function of age. Hear Res. 1996;100:101-106
  • 102.Schmiedt RA, Mills JH, Boettcher FA. Age-related loss of activity of auditory-nerve fibers. J Neurophysiol. 1996;76:2799-2803
  • 103.Johnsson LG, Felix H, Gleeson M, Pollk A. Observations on the pattern of sensorineural degeneration in the human cochlea. Acta Otolaryngol. (Suppl. Stockh.) 1990;470:88-95
Toplam 103 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Mehmet Boşnak Bu kişi benim

Ayhan Eralp Bu kişi benim

Yayımlanma Tarihi 1 Mart 2009
Yayımlandığı Sayı Yıl 2009 Cilt: 15 Sayı: 2

Kaynak Göster

APA Boşnak, M., & Eralp, A. (2009). Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal, 15(2), 56-65.
AMA Boşnak M, Eralp A. Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal. Mart 2009;15(2):56-65.
Chicago Boşnak, Mehmet, ve Ayhan Eralp. “Fizyolojik Ve Morfolojik değişmeler Ve gelişmelere Genel Bir bakış”. Gaziantep Medical Journal 15, sy. 2 (Mart 2009): 56-65.
EndNote Boşnak M, Eralp A (01 Mart 2009) Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal 15 2 56–65.
IEEE M. Boşnak ve A. Eralp, “Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış”, Gaziantep Medical Journal, c. 15, sy. 2, ss. 56–65, 2009.
ISNAD Boşnak, Mehmet - Eralp, Ayhan. “Fizyolojik Ve Morfolojik değişmeler Ve gelişmelere Genel Bir bakış”. Gaziantep Medical Journal 15/2 (Mart 2009), 56-65.
JAMA Boşnak M, Eralp A. Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal. 2009;15:56–65.
MLA Boşnak, Mehmet ve Ayhan Eralp. “Fizyolojik Ve Morfolojik değişmeler Ve gelişmelere Genel Bir bakış”. Gaziantep Medical Journal, c. 15, sy. 2, 2009, ss. 56-65.
Vancouver Boşnak M, Eralp A. Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal. 2009;15(2):56-65.