Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış

Mehmet Boşnak; Ayhan Eralp

A general overview to physiological and morphological changes and developments

Yıl 2009, Cilt: 15 Sayı: 2, 56 - 65, 01.03.2009

Öz

Presbycusis (age-related hearing loss) is one of the principal communicative and chronic medical disorders of our aged population. Preventative and curative biomedical interventions provide us with an understanding of the basis of this neural and molecular sensory deficit. The cochlear nucleus (CN) receives the outputs of the auditory portion of the inner ear, and sends these outputs to the centres where critical sound and perception analyses are conducted in parallel processing pathways of brainstem. This location plays a key role to process the sound. This location is an important place to investigate the structural and functional changes related to aging occuring in cochlear nucleus. Our goal is to reveal the neurophysiologic bases of functional changes which occur in mammalian CN related to aging.

Anahtar Kelimeler

Kaynakça

l.Willott JF, Parham K, Hunter KP. Comparison of the auditory sensitivity of neurons in the cochlear nucleus and inferior colliculus of young and aging C57BL/6J and CBA/J mice. Hear Res. 1991;53:78-94
2.Syka J. Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning. Physiol Rev. 2002;82:601-636
3.Thomas A, Herbst KG Social and psychological implications of acquired deafness for adults of employment age. Br J Audiol. 1980;14:76-85
4.Weinstein BE, Ventry IM. Hearing impairment and social isolation in the elderly. J Speech Hear Res. 1982;25:593-599
5.Mulrow CD, Aguilar C, Endicott JE, Tuley MR, Velez R, Charlip WS, et al. Quality-of-life changes and hearing impairment: a randomized trial. Ann Intern Med. 1990;113:188-194
6.Gordon-Salant S, Fitzgibbons PJ. Temporal factors and speech recognition performance in young and elderly listeners. J Speech Hear Res. 1993;36:1276-1285
7.Frisina DR, Frisina RD. Speech recognition in noise and presbycusis: relations to possible neural mechanisms. Hear Res. 1997; 106:95-104
8.Caspary DM, Schatteman TA, Hughes LF. Age-Related Changes in the Inhibitory Response Properties of Dorsal Cochlear Nucleus Output Neurons: Role of Inhibitory Inputs. The J Neurosci. 2005;25(47): 10952-10959
9.Frisina RD, Walton JP. Age-related structural and functional changes in the cochlear nucleus. Hear Res. 2006;216-217:216-223
lO.Schuknecht H. Pathology of the ear. Cambridge, MA, Harward University Press, 1974;388-403
ll.Schuknecht HF. Pathology of presbycusis. In, Goldstein JC, Kashima, HK and Koopman CF (eds), Geriatric Otorhinolaryngology. Inc., Toronto and Philadelphia, BD Decker, 1989;40-44
12.Schuknecht HF, Gacek MR. Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol. 1993;102:l-16
13.Liu XZ, Yan D. Ageing and hearing loss. J Pathol. 2007;21:188-197
14.Arnesen AR. Presbycusis - loss of neurons in the human cochlear nuclei. J Laryngol Otol. 1982;96:503-511
15.Welsh LW, Welsh JJ, Healy MP. Central presbycusis. The Laryngol. 1985;95:128-136
16.Willott JF, Bross LS, McFadden SL Morphology of the dorsal cochlear nucleus in C57BL/6J and CBA/J mice across the life span. J Comp Neurol. 1992;32:666-678
17.Hawkins JE, Miller JM, Rouse RC, Davis JA, Rarey K. Inner ear histopathology in aging rhesus monkeys (Maçaca mulatta). In, Davis RT and Leathers CW (eds) Behavior and Pathology of Aging in Rhesus Monkeys. Alan R. Liss, Inc., New York. 1985; 137-154
18.Dayal VS, Bhattacharyya TK. Comparative study of age-related cochlear hair cell loss. Ann Otol Rhinol Laryngol. 1986;95:510-513
19.Henry KR, Chole RA. Genotypic differences in behavioral, physiological and anatomical expressions of age-related hearing loss in the laboratory mouse. Audiology. 1980; 19:369-383
2O.Keithley EM,Feldman ML. Hair cell counts in an age-graded series of rat cochleas. Hear Res. 1982;8:249-262
21.Bhattacharyya TK, Dayal VS. Age-related cochlear hair cell loss in the chinchilla. Ann Otol Rhinol Laryngol. 1985;94:75-80
22.Bonne BA, Gruner MM, Harding GW. Morphological correlates of aging in the chinchilla cochlea. Hear Res. 1990;48:79-92
23.Bhattacharyya TK, Dayal VS. Influence of age on hair cell loss in the rabbit cochlea. Hear Res. 1989;40:179-184
24.Coleman JW. Hair cell loss as a function of age in the normal cochlea of the guniea pig. Acta Otolaryngol. 1976;82:33-40
25.Shimada A, Ebisu M, Morita T, Takeuchi T, Umemura T. Age-Related Changes in the Inhibitory Response Properties of Dorsal Cochlear Nucleus Output Neurons: Role of Inhibitory Inputs. J Vet Med Sci. 1998;60(l):41-48
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32.Tremblay KL, Piskosz M, Souza P. Aging alters the neural representation of speech cues. Neuro Report. 2002; 13:1865-1870
33.Tremblay KL, Piskosz M, Souza P. Effects of age and age-related hearing loss on the neural representation of speech cues. Clin Neurophysiol. 2003;114:1332-1343
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43.Emmerich E, Richter F, Reinhold U, Linss V, Linss W. Effects of industrial noise exposure on distortion product otoacoustic emissions (DPOAEs) and hair cell loss of the cochlea - long term experiments in awake guinea pigs. Hear Res. 2000; 148:9-17
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Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış

Yıl 2009, Cilt: 15 Sayı: 2, 56 - 65, 01.03.2009

Mehmet Boşnak Ayhan Eralp

Öz

Presbikuzi (yaşlanmaya bağlı olarak işitme gücünün azalması); yaşlanmış insanlarımızın başta gelen iletişimsel ve kronik tıbbi bozukluğudur. Önleyici ve iyileştirici biyomedikal girişimler sadece, bu duyu kaybının sinirsel ve moleküler temelini anlamamızı sağlar. Koklear nukleus (KN); iç kulağın, işitme duyusuna ait kısmının çıktılarını alır ve beyin sapındaki paralel işleme yollarında kritik ses analizi ve algılama yapılan merkezlere aktarır. Sesin işleme tabi tutulması için bu bölge, anahtar bir rol oynar. Bu bölge yaşlanmaya bağlı olarak KN'de meydana gelen yapısal ve fonksiyonel değişiklikleri incelemek için önemli bir yerdir. Amacımız, memeli KN'sinde yaşlanmaya bağlı olarak meydana gelen fonksiyonel değişikliklerin nörofizyolojik temellerini ortaya koymaktır.

Anahtar Kelimeler

Kaynakça

l.Willott JF, Parham K, Hunter KP. Comparison of the auditory sensitivity of neurons in the cochlear nucleus and inferior colliculus of young and aging C57BL/6J and CBA/J mice. Hear Res. 1991;53:78-94
2.Syka J. Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning. Physiol Rev. 2002;82:601-636
3.Thomas A, Herbst KG Social and psychological implications of acquired deafness for adults of employment age. Br J Audiol. 1980;14:76-85
4.Weinstein BE, Ventry IM. Hearing impairment and social isolation in the elderly. J Speech Hear Res. 1982;25:593-599
5.Mulrow CD, Aguilar C, Endicott JE, Tuley MR, Velez R, Charlip WS, et al. Quality-of-life changes and hearing impairment: a randomized trial. Ann Intern Med. 1990;113:188-194
6.Gordon-Salant S, Fitzgibbons PJ. Temporal factors and speech recognition performance in young and elderly listeners. J Speech Hear Res. 1993;36:1276-1285
7.Frisina DR, Frisina RD. Speech recognition in noise and presbycusis: relations to possible neural mechanisms. Hear Res. 1997; 106:95-104
8.Caspary DM, Schatteman TA, Hughes LF. Age-Related Changes in the Inhibitory Response Properties of Dorsal Cochlear Nucleus Output Neurons: Role of Inhibitory Inputs. The J Neurosci. 2005;25(47): 10952-10959
9.Frisina RD, Walton JP. Age-related structural and functional changes in the cochlear nucleus. Hear Res. 2006;216-217:216-223
lO.Schuknecht H. Pathology of the ear. Cambridge, MA, Harward University Press, 1974;388-403
ll.Schuknecht HF. Pathology of presbycusis. In, Goldstein JC, Kashima, HK and Koopman CF (eds), Geriatric Otorhinolaryngology. Inc., Toronto and Philadelphia, BD Decker, 1989;40-44
12.Schuknecht HF, Gacek MR. Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol. 1993;102:l-16
13.Liu XZ, Yan D. Ageing and hearing loss. J Pathol. 2007;21:188-197
14.Arnesen AR. Presbycusis - loss of neurons in the human cochlear nuclei. J Laryngol Otol. 1982;96:503-511
15.Welsh LW, Welsh JJ, Healy MP. Central presbycusis. The Laryngol. 1985;95:128-136
16.Willott JF, Bross LS, McFadden SL Morphology of the dorsal cochlear nucleus in C57BL/6J and CBA/J mice across the life span. J Comp Neurol. 1992;32:666-678
17.Hawkins JE, Miller JM, Rouse RC, Davis JA, Rarey K. Inner ear histopathology in aging rhesus monkeys (Maçaca mulatta). In, Davis RT and Leathers CW (eds) Behavior and Pathology of Aging in Rhesus Monkeys. Alan R. Liss, Inc., New York. 1985; 137-154
18.Dayal VS, Bhattacharyya TK. Comparative study of age-related cochlear hair cell loss. Ann Otol Rhinol Laryngol. 1986;95:510-513
19.Henry KR, Chole RA. Genotypic differences in behavioral, physiological and anatomical expressions of age-related hearing loss in the laboratory mouse. Audiology. 1980; 19:369-383
2O.Keithley EM,Feldman ML. Hair cell counts in an age-graded series of rat cochleas. Hear Res. 1982;8:249-262
21.Bhattacharyya TK, Dayal VS. Age-related cochlear hair cell loss in the chinchilla. Ann Otol Rhinol Laryngol. 1985;94:75-80
22.Bonne BA, Gruner MM, Harding GW. Morphological correlates of aging in the chinchilla cochlea. Hear Res. 1990;48:79-92
23.Bhattacharyya TK, Dayal VS. Influence of age on hair cell loss in the rabbit cochlea. Hear Res. 1989;40:179-184
24.Coleman JW. Hair cell loss as a function of age in the normal cochlea of the guniea pig. Acta Otolaryngol. 1976;82:33-40
25.Shimada A, Ebisu M, Morita T, Takeuchi T, Umemura T. Age-Related Changes in the Inhibitory Response Properties of Dorsal Cochlear Nucleus Output Neurons: Role of Inhibitory Inputs. J Vet Med Sci. 1998;60(l):41-48
26.Dubno JR, Dirks DD, Morgan DE. Effects of age and mild hearing loss on speech recognition in noise. J Acoust Soc Am. 1984;76:87-96
27.Moore BC, Peters RW, Glasberg BR. Detection of temporal gaps in sinusoids by elderly subjects with and without hearing loss. J Acoust Soc Am. 1992;92:1923-1932
28.Fitzgibbons PJ, Gordon-Salant S. Age effects on measures of auditory duration discrimination. J Speech Hear Res. 1994;37:662-670
29.Schneider BA, Pichora-Fuller MK, Kowalchuk D, Lamb M. Gap detection and the precedence effect in young and old adults. J Acoust Soc Am. 1994;95:980-991
30-Snell KB. Age-related changes in temporal gap detection. J Acöust Soc Am. 1997;101:2214-2220
31.Strouse A, Ashmead DH, Ohde RN, Grantham DW. Temporal processing in the aging auditory system. J Acoust Soc Am. 1998; 104:2385-2399
32.Tremblay KL, Piskosz M, Souza P. Aging alters the neural representation of speech cues. Neuro Report. 2002; 13:1865-1870
33.Tremblay KL, Piskosz M, Souza P. Effects of age and age-related hearing loss on the neural representation of speech cues. Clin Neurophysiol. 2003;114:1332-1343
34.Ostroff JM, McDonald KL, Schneider BA, Alain C. Aging and the processing of sound duration in human auditory cortex. Hear Res. 2003; 181:1-7
35.Caspary DM, Raza A, Lawhorn Armour BA, Pippin J, Arneric SP. Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis. J Neurosci. 1990;10:2363-2372
36.Caspary DM, Backoff PM, Finlayson PG, Palombi PS. Inhibitory inputs modulate discharge rate within frequency receptive fields of anteroventral cochlear nucleus. J Neurophysiol. 1994;72:2124-2133
37.Caspary DM, Milbrandt JC, Helfert RH. Central auditory aging: GABA changes in the inferior colliculus. Exp Gerontol. 1995;30:349-360
38.Schmolesky MT, Wang Y, Pu M, Leventhal AG. Degradation of stimulus selectivity of visual cortical cells in senescent rhesus monkeys. Nat Neurosci. 2000;3:384-390
39.Caspary DM, Salvi PJ, Helfert RH, Brozoski TJ, Bauer CA. Neuropharmacology of noise induced hearing loss in brainstem auditory structures. In: Noise induced hearing loss: mechanisms of damage and means of prevention. Henderson D, Prasher D, Kopke R, Salvi RJ, Hamernik R. (eds), London: NRN. 2001;169-186
40.Mendelson JR, Ricketts C. Age-related temporal processing speed deterioration in auditory cortex. Hear Res. 2001; 158:84-94
41.Caspary DM, Palombi PS, Hughes LF. GABAergic inputs shape responses to amplitude modulated stimuli in the inferior colliculus. Hear Res. 2002;168:163-173
42.Leventhal AG, Wang Y, Pu M, Zhou Y, Ma Y. GABA and its agonists improved visual cortical function in senescent monkeys. Hear Res. 2003;300:812-815
43.Emmerich E, Richter F, Reinhold U, Linss V, Linss W. Effects of industrial noise exposure on distortion product otoacoustic emissions (DPOAEs) and hair cell loss of the cochlea - long term experiments in awake guinea pigs. Hear Res. 2000; 148:9-17
44.Aran JM, Hiel H, Hayashida T. Noise, aminoglycosides, diuretics. In Noise Induced Hearing Loss, Dancer A, Henderson D, Salvi R, Hamernik R (eds). Mosby: St Louis, 1992; 188-195
45.Boettcher FA, Gratton MA, Bancroft BR, Spongr V. Interaction of noise and other agents: recent advances. In Noise Induced Hearing Loss, Henderson D, Salvi R, Hamernik R (eds). Mosby: St Louis, 1992;175-187
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56.Zheng QY, Johnson KR, Erway LC. Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. Hear Res. 2001; 154:45-53
57.Noben-Trauth K, Zheng QY, Johnson KR. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nat Genet. 2003;35:21-23
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60.Ohlemiller KK, McFadden SL, Ding DL, Lear PMI, Ho YS. Targeted mutation of the gene for cellular glutathione peroxidase (Gpxl) increases noise-induced hearing loss in mice. Assoc Res Otolaryngol. 2000; 1:243-254
61.McFadden SL, Ohlemiller KK, Ding D, Shero M, Salvi RJ. The influence of superoxide dismutase and glutathione peroxidase deficiencies on noise-induced hearing loss in mice. Noise Health. 2001;3:49-64
62.Fortunato G, Marciano E, Zarrilli F, Mazzaccara C, Intrieri M, Calcagno G, et al. Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. Clin Chem. 2004;50:2012-2018
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64.Wang Y, Manis PB. Synaptic transmission at the cochlear nucleus end bulb synapse during age-related hearing loss in mice. J Neurophysiol. 2005;94:1814-1824
65.Walton JP, Frisina RD, Ison JE, O'Neill WE. Neural correlates of behavioral gap detection in the inferior colliculus of the young CBA mouse. J Comp Physiol A. 1997;181:161-176
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68.Frisina RD. Possible neurochemical and neuroanatomical bases of age-related hearing loss -presbycusis. Sem. Hearing: Innovations in Aging Auditory Res. 2001a;22:213-225
69.Frisina RD. Anatomical and neurochemical bases of presbycusis. In: Hof PR, Mobbs CV. (eds.), Functional Neurobiology of Aging . Academic Press, San Diego, 2001b;531-547
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Toplam 103 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Bölüm	Makaleler
Yazarlar	Mehmet Boşnak Bu kişi benim Ayhan Eralp Bu kişi benim
Yayımlanma Tarihi	1 Mart 2009
Yayımlandığı Sayı	Yıl 2009 Cilt: 15 Sayı: 2

Kaynak Göster

APA	Boşnak, M., & Eralp, A. (2009). Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal, 15(2), 56-65.
AMA	Boşnak M, Eralp A. Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal. Mart 2009;15(2):56-65.
Chicago	Boşnak, Mehmet, ve Ayhan Eralp. “Fizyolojik Ve Morfolojik değişmeler Ve gelişmelere Genel Bir bakış”. Gaziantep Medical Journal 15, sy. 2 (Mart 2009): 56-65.
EndNote	Boşnak M, Eralp A (01 Mart 2009) Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal 15 2 56–65.
IEEE	M. Boşnak ve A. Eralp, “Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış”, Gaziantep Medical Journal, c. 15, sy. 2, ss. 56–65, 2009.
ISNAD	Boşnak, Mehmet - Eralp, Ayhan. “Fizyolojik Ve Morfolojik değişmeler Ve gelişmelere Genel Bir bakış”. Gaziantep Medical Journal 15/2 (Mart 2009), 56-65.
JAMA	Boşnak M, Eralp A. Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal. 2009;15:56–65.
MLA	Boşnak, Mehmet ve Ayhan Eralp. “Fizyolojik Ve Morfolojik değişmeler Ve gelişmelere Genel Bir bakış”. Gaziantep Medical Journal, c. 15, sy. 2, 2009, ss. 56-65.
Vancouver	Boşnak M, Eralp A. Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal. 2009;15(2):56-65.

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