genel tıp derg Genel Tıp Dergisi 2602-3741 Selçuk Üniversitesi 10.54005/geneltip.1667395 Dermatology Dermatoloji Histopathological Diagnosis Transformed Into Clinical Diagnosis Inverted Follicular Keratosis, Case Report Klinik Tanıya Dönüşen Histopatolojik Tanı: Inverted Foliküler Keratoz, Vaka Sunumu https://orcid.org/0009-0002-4955-9385 Gökkaya Gamze SELÇUK ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0009-0000-9579-113X Pektaş Ömer Erkam SELÇUK ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0002-0798-1310 Celik Murat SELÇUK ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0003-4675-8127 Yavuz Cahit SELÇUK ÜNİVERSİTESİ, TIP FAKÜLTESİ 04 13 2026 36 2026 1 3 04 15 2025 12 01 2025 Copyright © 1990, Genel Tıp Dergisi 1990 Genel Tıp Dergisi

Inverted follicular keratosis (IFK) is a rare benign tumor characterized by endophytic proliferation originating from the infundibulum of the hair follicle (1,2). Although not frequently encountered, we believe that inverted follicular keratosis should be considered a distinct entity to keep in mind due to its potential to be confused with conditions such as verruca vulgaris, seborrheic keratosis, actinic keratosis, keratoacanthoma, basal cell carcinoma, and squamous cell carcinoma.

İnverted foliküler keratoz nadir olarak ortaya çıkan kıl folikülünün infindibulum kısmından köken alan endofitik büyüme ile karakterize benign bir tümördür (1,2). Çok sık görülmemekle birlikte karışabileceği; verruka vulgaris, seboreik keratoz, aktinik keratoz, keratoakantom, bazal hücreli karsinom ve skuamöz hücreli karsinom gibi durumlar nedeniyle inverted foliküler keratozun akılda tutulması gereken bir antite olması gerektiğini düşünmekteyiz.

 Actinic changes Follicular keratosis Histopathology Aktinik değişiklikler Foliküler keratoz Histopatoloji 1-Heriyanto DS, Lau V, Phang V. Two distinct lesions of inverted follicular keratosis of the scalp: A case report. Cureus. 2022 Nov;3;14(11). doi: 10.7759/cureus.31055. 2-Zaballos P, Gómez-Martín I, Martín JM, Bañuls J. Dermoscopy of adnexal tumors. Dermatol Clin. 2018 Oct;36(4):397-412. doi: 10.1016/j.det.2018.05.007. 3-Karadag AS, Ozlu E, Uzuncakmak TK, Akdeniz N, Cobanoglu B, Oman B. Inverted follicular keratosis successfully treated with imiquimod. Indian Dermatol Online J. 2016;7(3):177-179. doi: 10.4103/2229-5178.182354. 4-Armengot-Carbo M, Abrego A, Gonzalez T, Alarcon I, Alos L, Carrera C, Malvehy J, Puig S. Inverted follicular keratosis: Dermoscopic and reflectance confocal microscopic features. Dermatology. 2013;227(1):62-6. doi: 10.1159/000351715. 5-Spielvogel RL, Austin C, Ackerman AB. Inverted follicular keratosis is not a specific keratosis but a verruca vulgaris (or seborrheic keratosis) with squamous eddies. Am J Dermatopathol. 1983;5(5):427–42. doi: 10.1097/00000372-198310000-00003. 6- Thom GA, Quirk CJ, Heenan PJ. Inverted follicular keratosis simulating malignant melanoma. Australas J Dermatol. 2004;45(1):55–7. doi: 10.1111/j.1440-0960.2004.00032.x. 7- Ruhoy SM, Thomas D, Nuovo GJ. Multiple inverted follicular keratoses as a presenting sign of Cowden's syndrome: Case report with human papillomavirus studies. J Am Acad Dermatol. 2004;51(3):411–5. doi: 10.1016/j.jaad.2003.12.049. 8- Baklouti M, Sellami K, Mellouli M, Rekik M, Chaabouni R, Masmoudi A, Sellami T, Turki H. Inverted Follicular Keratosis: A Retrospective Study Over 10 Years. Indian J Dermatol. 2023;68(1):122.doi: 10.4103/ijd.ijd_968_21. 9-Ray A, Panda M, Samant S, Mohanty P. A rare case of inverted follicular keratosis in an elderly male: Dermoscopic and histopathological overview with therapeutic response to imiquimod. Indian J Dermatol Venereol Leprol. 2021;87(3);455. doi: 10.25259/IJDVL_224_20.