genel tıp derg Genel Tıp Dergisi 2602-3741 Selçuk Üniversitesi 10.54005/geneltip.1771350 Radiology and Organ Imaging Radyoloji ve Organ Görüntüleme Microwave Ablation versus Combined Ethanol–Microwave Ablation in Symptomatic Benign Thyroid Nodules: A Single-Center Comparative Study Semptomatik İyi Huylu Tiroid Nodüllerinde Mikrodalga Ablasyon ile Kombine Etanol-Mikrodalga Ablasyonun Karşılaştırılması: Tek Merkezli Karşılaştırmalı Çalışma https://orcid.org/0000-0002-2054-1571 Bilgin Erkan SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0002-2111-6294 İmamoğlu Cetin SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0002-2150-8650 Bayrak Ahmet SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0001-8433-4769 Or Koca Arzu SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0009-0007-4792-8083 Güler Hadi Sertaç SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0001-9075-9237 Şara Halil İbrahim Beyhekim Eğitim ve Araştırma Hastanesi 04 21 2026 36 2026 1 5 08 24 2025 10 17 2025 Copyright © 1990, Genel Tıp Dergisi 1990 Genel Tıp Dergisi

Aim: To compare the efficacy and safety of ultrasound-guided microwave ablation (MWA) and combined ethanol plus microwave ablation (EA+MWA) in patients with symptomatic benign thyroid nodules.Materials and Methods: This retrospective study included 24 patients (25 nodules) treated between January 2023 and January 2025. Patients with predominantly solid nodules underwent MWA (n = 18), while patients with nodules with prominent cystic components received EA+MWA (n = 6). Nodule volumes were calculated using the ellipsoid formula before and 6 months after the procedure, and the volume reduction ratio (VRR%) was determined.Results: The mean VRR at 6 months was 62.15% ± 9.61 in the MWA group and 74.37% ± 14.27 in the EA+MWA group. Although higher in the EA+MWA group, the difference did not reach statistical significance (p = 0.094). Both groups demonstrated substantial volume reduction and were free from major complications. Transient hoarseness occurred in four patients.Conclusion: Both MWA and EA+MWA are effective and safe for the treatment of symptomatic benign thyroid nodules. The combination of EA and MWA may provide greater volume reduction in nodules with prominent cystic components.

Amaç: Semptomatik iyi huylu tiroid nodüllü hastalarda ultrason rehberliğinde mikrodalga ablasyonu (MWA) ve kombine etanol artı mikrodalga ablasyonunun (EA+MWA) etkinliğini ve güvenliğini karşılaştırmak.Gereç ve Yöntemler: Bu retrospektif çalışmaya Ocak 2023 ile Ocak 2025 tarihleri arasında tedavi edilen 24 hasta (25 nodül) dahil edildi. Ağırlıklı olarak solid nodüllü hastalara MWA (n = 18) uygulanırken, belirgin kistik komponentli nodülü olan hastalara EA+MWA (n = 6) uygulandı. Nodül hacimleri, elipsoid formülü kullanılarak işlemden önce ve 6 ay sonra hesaplandı ve hacim azalma oranı (VRR%) belirlendi.Bulgular: 6. ayda ortalama VRR, MWA grubunda %62,15 ± 9,61, EA+MWA grubunda ise %74,37 ± 14,27 olarak bulundu. EA+MWA grubunda daha yüksek olmasına rağmen, fark istatistiksel olarak anlamlı değildi (p = 0,094). Her iki grupta da önemli hacim azalması görüldü ve majör komplikasyonlar görülmedi. Dört hastada geçici ses kısıklığı görüldü.Sonuç: Hem MWA hem de EA+MWA, semptomatik iyi huylu tiroid nodüllerinin tedavisinde etkili ve güvenlidir. EA ve MWA kombinasyonu, belirgin kistik bileşenlere sahip nodüllerde daha fazla hacim azalması sağlayabilir.

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