<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article         dtd-version="1.4">
            <front>

                <journal-meta>
                                                                <journal-id>j contemp med</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Çağdaş Tıp Dergisi</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2146-6009</issn>
                                                                                            <publisher>
                    <publisher-name>Rabia YILMAZ</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.16899/ctd.03180</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Health Care Administration</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Sağlık Kurumları Yönetimi</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <article-title>Major  Depresif  Bozukluk’ Tanımı, Etyolojisi ve Epidemiyolojisi: Bir Gözden Geçirme</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="en">
                                    <trans-title>Major Depressive Disorder&#039; Definition, Etiology and Epidemiology: A Review</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                <name>
                                    <surname>Helvacı Çelik</surname>
                                    <given-names>Fatmagül</given-names>
                                </name>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Hocaoğlu</surname>
                                    <given-names>Çiçek</given-names>
                                </name>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20161019">
                    <day>10</day>
                    <month>19</month>
                    <year>2016</year>
                </pub-date>
                                        <volume>6</volume>
                                        <issue>1</issue>
                                        <fpage>51</fpage>
                                        <lpage>66</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20160221">
                        <day>02</day>
                        <month>21</month>
                        <year>2016</year>
                    </date>
                                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2011, Çağdaş Tıp Dergisi</copyright-statement>
                    <copyright-year>2011</copyright-year>
                    <copyright-holder>Çağdaş Tıp Dergisi</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>Depresyon tüm nüfusu etkileyen yaygın psikiyatrik bozukluklardan biridir. Tedavi edilmediğinde erken ölüm, genel sağlık durumunda bozulma gibi olumsuz sonuçlar yaratırken, doğru tanınıp, uygun bir şekilde tedavi edildiğinde hastanın yaşam kalitesini arttırmak mümkün olabilmektedir. Depresyonun klinik olarak farklı ve bazen tanısı zor olan birkaç alt tipi bulunur. Bu bozuklukların tanı ve tedavileri, psikiyatristler dışındaki hekimleri de, bu bozuklukların genel tıbbi hastalıkların seyrini ve prognozunu etkilemesi bakımından, ilgilendirmektedir. Bu yazıda depresyonun epidemiyoloji, etyoloji, fizyopatoloji ve tanısının güncel bir özeti yer almaktadır.</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="en">
                            <p>Depression is one of the most common psychiatric disorders influencing the all population. Untreated depression may lead to early death and worsening in general health. Depression has several clinically distinct subtypes which are sometimes difficult to diagnose. Diagnosis and treatment of these disorders are of concern to physicians other than psychiatrists, because of their effect on course and prognosis of general medical diseases. This is a concise and up to date overview of the epidemiology,etiology  physiopathology and diagnosis of major depressive disorder.</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>Major depresif bozukluk</kwd>
                                                    <kwd>  etyoloji</kwd>
                                                    <kwd>  epidemiyoloji</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="en">
                                                    <kwd>Major depressive disorder</kwd>
                                                    <kwd>  etiology</kwd>
                                                    <kwd>  epidemiology</kwd>
                                            </kwd-group>
                                                                                                            </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Rihmer Z, Angst J. (2007). Duygudurum Bozuklukları: Epidemiyoloji. In: Sadock B, Sadock V,eds. Aydın H, Bozkurt A, (çev. eds). Türkçe: Kaplan &amp; Sadock’s Com- prehensive Text book of Psychiatry. 8. Baskı. Ankara: Öncü Basımevi,1575-1582</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Işık E., Işık U., Taner Y.(2013), Çoçuk, Ergen, Erişkin ve Yaşlılarda Depresif ve Bipolar Bozukluklar; Ziraat Gu- rup Matbaacılık, Ankara.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Olchanski, N., McInnis Myers, M., Halseth, M., Cyr, P. L., Bockstedt, L., Goss, T. F., &amp; Howland, R. H. (2013). The economic burden of treatment-resistant depres- sion. Clinical therapeutics, 35(4), 512-522.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Köroğlu E. (1997). Psikiyatri Temel Kitabı 1. cilt. An- kara: Hekimler Yayın Birliğİ, 389-428.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Köroğlu E, ed. (2000). Amerikan Psikiyatri Birliği. DSM- IV-TR Tanı Ölçütleri, 2. Baskı. Ankara: Hekimler Yayın Birliği, 151-63.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">Cimilli C.,( 2001). Depresyonda sosyal ve kültürel etmenler. Duygu durumu bozuklukları- 4. Çizgi Tıp yayınevi, Ankara; 157-68.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Angst, J. (1992). Epidemiology of depression. Psy- chopharmacology, 106(1), S71-S74.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Kessler, R. C., McGonagle, K. A., Zhao, S., Nelson, C. B., Hughes, M., Eshleman, S., ... &amp; Kendler, K. S. (1994). Lifetime and 12-month prevalence of DSM-III-R psy- chiatric disorders in the United States: results from the National Comorbidity Survey. Archives of general psychiatry, 51(1), 8-9.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Doğan O, Gülmez H, Ketenoğlu C, Kılıçkap Z, Özbek H, Akyüz G,( 1995). Ruhsal bozuklukların epidemiyolojisi, Sivas, Dilek Matbaası.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">Kessler, R. C., &amp; Walters, E. E. (1998). Epidemiology of DSM-III-R major depression and minor depression among adolescents and young adults in the national comorbidity survey. Depression and anxiety, 7(1), 3-14.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">Horwath, E., Cohen, R. S., &amp; Weissman, M. M. (2002). Epidemiology of depressive and anxiety disorders. Textbook in psychiatric epidemiology, 2002, 389-426.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">Myer, L., Smit, J., Roux, L. L., Parker, S., Stein, D. J., &amp; Seedat, S. (2008). Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scales. AIDS patient care and STDs, 22(2), 147-158.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">McIntosh, E., Gillanders, D., &amp; Rodgers, S. (2010). Ru- mination, goal linking, daily hassles and life events in major depression. Clinical psychology &amp; psychothera- py, 17(1), 33-43.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">Akiskal HS., (2000). Mood disorders. İntroduction and overwiev. İn: BJ Sadock, VA Sadock (eds). Com- prehensive Textbook of Psychiatry Seventh edition. Baltimore:Lippincott Williams and Wilkins 2000; 1284-98</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">Klose, M., &amp; Jacobi, F. (2004). Can gender differences in the prevalence of mental disorders be explained by sociodemographic factors?. Archives of women’s mental health, 7(2), 133-148.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">Noble, R. E. (2005). Depression in women. Metabo- lism, 54(5), 49-52.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">Lee L, Casanueva C, Martin SL (2005) Depression among female family planning patients: prevalence, risk factors, and use of mental health services. Journal of Women’s Health, 2005; 14: 225-232.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">Ross E, Burström B, Saastamoinen P ve ark. (2005) A comparative study of the patterning of women’s health by family status and employment status in Finland and Sweden. Social Science Medicine, 60: 2443-2451.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">Andrade, L., Caraveo-anduaga, J. J., Berglund, P., Bijl, R. V., Graaf, R. D., Vollebergh, W., ... &amp; Wittchen, H. U. (2003). The epidemiology of major depressive epi- sodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) Surveys. International journal of methods in psychiatric research, 12(1), 3-21.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">Oldehinkel, A. J., Wittchen, H. U., &amp; Schuster, P. (1999). Prevalence, 20-month incidence and outcome of uni- polar depressive disorders in a community sample of adolescents. Psychological Medicine, 29(03), 655-668.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">Weissman, M. M., Bland, R. C., Canino, G. J., Faravelli, C., Greenwald, S., Hwu, H. G., ... &amp; Yeh, E. K. (1996). Cross-national epidemiology of major depression and bipolar disorder. Jama, 276(4), 293-299.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">Regier, D. A., Farmer, M. E., Rae, D. S., Myers, J. K., Kramer, M. R. L. N., Robins, L. N., ... &amp; Locke, B. Z. (1993). One-month prevalence of mental disorders in the United States and sociodemographic character- istics: the Epidemiologic Catchment Area study. Acta Psychiatrica Scandinavica, 88(1), 35-47.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">Kessler, R. C., Zhao, S., Blazer, D. G., &amp; Swartz, M. (1997). Prevalence, correlates, and course of minor depression and major depression in the National Co- morbidity Survey. Journal of affective disorders, 45(1- 2), 19-30.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">Kessler, R. C. (2003). Epidemiology of women and de- pression. Journal of affective disorders, 74(1), 5-13.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">Lehtinen, V., &amp; Joukamaa, M. (1994). Epidemiology of depression: prevalence, risk factors and treatment situ- ation. Acta Psychiatrica Scandinavica, 89(s377), 7-10.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">Rothschild, A. J. (1999). Mood disorders. AM Nicholi Jr(Ed.), The Harvard Guide to Psychiatry, third ed., Cambridge, the Belknap Press of Harvard University Press, 1999,p.281-307</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">Kessler, R. C., &amp; Wang, P. S. (2002). Epidemiology of depression. Handbook of depression, 2, 5-22.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">Erol N, Kılıç C, Ulusoy M, Keçeci M, Şimşek Z. Türkiye ruh sağlığı profili. Ankara, Eksen Tanıtım.</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">Uçku R, Küey L. (1992). Yaşlılarda depresyon epidemiyolojisi-yarıkentsel bir bölgede 65 yaş üstü yaşlılarda kesitsel bir alan çalışması. Nöropsikiyatri arşivi, 29:15–20.</mixed-citation>
                    </ref>
                                    <ref id="ref30">
                        <label>30</label>
                        <mixed-citation publication-type="journal">Kaya B, Kaya M.( 2007). 1960’lardan günümüze depr- esyonun epidemiyolojisi: Tarihsel bir bakış.Klinik Psiki- yatri;10(6):3-10</mixed-citation>
                    </ref>
                                    <ref id="ref31">
                        <label>31</label>
                        <mixed-citation publication-type="journal">Elovainio, M., Pulkki-Råback, L., Jokela, M., Kivimäki, M., Hintsanen, M., Hintsa, T., ... &amp; Keltikangas-Järvin- en, L. (2012). Socioeconomic status and the devel- opment of depressive symptoms from childhood to adulthood: A longitudinal analysis across 27 years of follow-up in the Young Finns study. Social Science &amp; Medicine, 74(6), 923-929.</mixed-citation>
                    </ref>
                                    <ref id="ref32">
                        <label>32</label>
                        <mixed-citation publication-type="journal">Mann, J. J. (1999). Role of the serotonergic system in the pathogenesis of major depression and suicidal be- havior. Neuropsychopharmacology, 21, 99S-105S.</mixed-citation>
                    </ref>
                                    <ref id="ref33">
                        <label>33</label>
                        <mixed-citation publication-type="journal">Delgado PL. Pathogenesis of Mood Disorders.In:Stein DJ, Kuffer DJ, Schatzberg AF, eds. Mood Disorders Text Book. Washington: American Psychiatric Publishing; 2006.p.100-16.</mixed-citation>
                    </ref>
                                    <ref id="ref34">
                        <label>34</label>
                        <mixed-citation publication-type="journal">Tamam, L., &amp; Zeren, T. (2002). Depresyonda seroton- erjik düzenekler. Klinik Psikiyatri Dergisi, 5, 11-18.</mixed-citation>
                    </ref>
                                    <ref id="ref35">
                        <label>35</label>
                        <mixed-citation publication-type="journal">Thase ME. Mood disorders: Neurobiology. Kaplan &amp; Sadock’s Comprehensive Textbook of Psychiatry. 9th ed. Philadelphia: Lippincott, Williams and Wilkins; 2009. p.1664-74.</mixed-citation>
                    </ref>
                                    <ref id="ref36">
                        <label>36</label>
                        <mixed-citation publication-type="journal">Pandey, G. N., &amp; Dwivedi, Y. (2007). Noradrenergic function in suicide. Archives of suicide research, 11(3), 235-246.</mixed-citation>
                    </ref>
                                    <ref id="ref37">
                        <label>37</label>
                        <mixed-citation publication-type="journal">Delgado, P. L., &amp; Moreno, F. A. (1999). Role of norepi- nephrine in depression. The Journal of clinical psychi- atry, 61, 5-12.</mixed-citation>
                    </ref>
                                    <ref id="ref38">
                        <label>38</label>
                        <mixed-citation publication-type="journal">Albayrak, E. Ö., &amp; Ceylan, M. E. Depresyon Etiyolo- jisinde Nörobiyolojik Etkenler. Düsünen Adam Dergisi 2004.</mixed-citation>
                    </ref>
                                    <ref id="ref39">
                        <label>39</label>
                        <mixed-citation publication-type="journal">Nutt, D. J., Baldwin, D. S., &amp; Clayton, A. H. (2006). The role of dopamine and norepinephrine in depression and antidepressant treatment. Journal of Clinical Psy- chiatry, 67, 3.</mixed-citation>
                    </ref>
                                    <ref id="ref40">
                        <label>40</label>
                        <mixed-citation publication-type="journal">Conn PJ, Pin JP (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Phar- macol Toxicol, 37:205-237.</mixed-citation>
                    </ref>
                                    <ref id="ref41">
                        <label>41</label>
                        <mixed-citation publication-type="journal">Sanacora G (2002) Evidence for GABAergic and glu- tamatergic involvement in the pathophysiology and treatment of depressive disorders. Biological Psychia- try HAH D’haenen. JA denBoer, P Willner (Ed), West Sussex, John Wiley &amp; Sons, s.739-749.</mixed-citation>
                    </ref>
                                    <ref id="ref42">
                        <label>42</label>
                        <mixed-citation publication-type="journal">Pin JP, Duvoisin R (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacol- ogy, 34:1-26.</mixed-citation>
                    </ref>
                                    <ref id="ref43">
                        <label>43</label>
                        <mixed-citation publication-type="journal">Danysz W, Parsons CG, Bresnik I ve ark. (1996) Glu- tamate in CNS Disorders. Drugs News Perspectives, 8:261-277.</mixed-citation>
                    </ref>
                                    <ref id="ref44">
                        <label>44</label>
                        <mixed-citation publication-type="journal">Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., &amp; Drevets, W. C. (2007). Reduced prefrontal glutamate/glutamine and γ-aminobutyric acid levels in major depression determined using proton mag- netic resonance spectroscopy. Archives of General Psychiatry, 64(2), 193-200.</mixed-citation>
                    </ref>
                                    <ref id="ref45">
                        <label>45</label>
                        <mixed-citation publication-type="journal">Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., ... &amp; Manji, H. K. (2006). A randomized trial of an N-methyl-D-aspartate an- tagonist in treatment-resistant major depression. Ar- chives of general psychiatry, 63(8), 856-864.</mixed-citation>
                    </ref>
                                    <ref id="ref46">
                        <label>46</label>
                        <mixed-citation publication-type="journal">Kendell, S. F., Krystal, J. H., &amp; Sanacora, G. (2005). GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert opinion on therapeutic targets, 9(1), 153-168.</mixed-citation>
                    </ref>
                                    <ref id="ref47">
                        <label>47</label>
                        <mixed-citation publication-type="journal">Feyissa, A. M., Chandran, A., Stockmeier, C. A., &amp; Ka- rolewicz, B. (2009). Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the pre- frontal cortex in major depression. Progress in Neuro- Psychopharmacology and Biological Psychiatry, 33(1), 70-75.</mixed-citation>
                    </ref>
                                    <ref id="ref48">
                        <label>48</label>
                        <mixed-citation publication-type="journal">Schneider, B., &amp; Prvulovic, D. (2013). Novel biomark- ers in major depression. Current opinion in psychiatry, 26(1), 47-53.</mixed-citation>
                    </ref>
                                    <ref id="ref49">
                        <label>49</label>
                        <mixed-citation publication-type="journal">Seidman SN.(2007). Duygudurum bozukluklarının psikonöroendokrinolojisi. Oral T, editör. Duygudu- rum bozuklukları. 1. Baskı. İstanbul, Sigma Publish- ing;.117-130.</mixed-citation>
                    </ref>
                                    <ref id="ref50">
                        <label>50</label>
                        <mixed-citation publication-type="journal">Eşel E.(2002). Depresyondaki nöroendokrinolojik bul- gular. Klinik Psikiyatri; 4:35-50.</mixed-citation>
                    </ref>
                                    <ref id="ref51">
                        <label>51</label>
                        <mixed-citation publication-type="journal">Joffe, R. T., &amp; Marriott, M. (2000). Thyroid hormone levels and recurrence of major depression. American Journal of Psychiatry, 157(10), 1689-1691.</mixed-citation>
                    </ref>
                                    <ref id="ref52">
                        <label>52</label>
                        <mixed-citation publication-type="journal">Rajkowska G.(2006). Anatomic Pathology. In: Stein DJ, Kuffer DJ, Schatzberg AF, eds. Mood Disorders Text Book. Washington: American Psychiatric Publishing;179-95</mixed-citation>
                    </ref>
                                    <ref id="ref53">
                        <label>53</label>
                        <mixed-citation publication-type="journal">Bremner, J. D., Vythilingam, M., Vermetten, E., Nazeer, A., Adil, J., Khan, S., ... &amp; Charney, D. S. (2002). Re- duced volume of orbitofrontal cortex in major depres- sion. Biological psychiatry, 51(4), 273-279.</mixed-citation>
                    </ref>
                                    <ref id="ref54">
                        <label>54</label>
                        <mixed-citation publication-type="journal">Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., &amp; Charney, D. S. (2000). Hippocam- pal volume reduction in major depression. American Journal of Psychiatry, 157(1), 115-118.</mixed-citation>
                    </ref>
                                    <ref id="ref55">
                        <label>55</label>
                        <mixed-citation publication-type="journal">Schweitzer, I., Tuckwell, V., Ames, D., &amp; O’brien, J. (2001). Structural neuroimaging studies in late-life depression: a review. World Journal of Biological Psy- chiatry, 2(2), 83-88.</mixed-citation>
                    </ref>
                                    <ref id="ref56">
                        <label>56</label>
                        <mixed-citation publication-type="journal">Özpoyraz N. (2002). Depresyonda nöroanatomik bağlantılar. Klinik Psikiyatri, 4:68-72.</mixed-citation>
                    </ref>
                                    <ref id="ref57">
                        <label>57</label>
                        <mixed-citation publication-type="journal">Sullivan, P. F., Neale, M. C., &amp; Kendler, K. S. (2000). Genetic epidemiology of major depression: review and meta-analysis. American Journal of Psychiatry, 157(10), 1552-1562.</mixed-citation>
                    </ref>
                                    <ref id="ref58">
                        <label>58</label>
                        <mixed-citation publication-type="journal">Levinson, D. F. (2006). The genetics of depression: a review. Biological psychiatry, 60(2), 84-92.</mixed-citation>
                    </ref>
                                    <ref id="ref59">
                        <label>59</label>
                        <mixed-citation publication-type="journal">Ersan E, Abay E. Depresyonun genetik nedenleri. Du- ygudurum dizisi.2001;6:277-82.</mixed-citation>
                    </ref>
                                    <ref id="ref60">
                        <label>60</label>
                        <mixed-citation publication-type="journal">Elder, B. L., &amp; Mosack, V. (2011). Genetics of depres- sion: an overview of the current science. Issues in mental health nursing, 32(4), 192-202.</mixed-citation>
                    </ref>
                                    <ref id="ref61">
                        <label>61</label>
                        <mixed-citation publication-type="journal">Holmans, P., Weissman, M., Zubenko, G., Scheftner, W., Crowe, R., DePaulo, J., ... &amp; Levinson, D. (2007). Genetics of recurrent early-onset major depression (GenRED): final genome scan report. American Jour- nal of Psychiatry, 164(2), 248-258.</mixed-citation>
                    </ref>
                                    <ref id="ref62">
                        <label>62</label>
                        <mixed-citation publication-type="journal">Abkevich, V., Camp, N. J., Hensel, C. H., Neff, C. D., Russell, D. L., Hughes, D. C., ... &amp; Cannon-Albright, L. (2003). Predisposition locus for major depression at chromosome 12q22-12q23. 2. The American Journal of Human Genetics, 73(6), 1271-1281. Celik ve ark.</mixed-citation>
                    </ref>
                                    <ref id="ref63">
                        <label>63</label>
                        <mixed-citation publication-type="journal">Hamilton, S. P., Fyer, A. J., Durner, M., Heiman, G. A., de Leon, A. B., Hodge, S. E., ... &amp; Weissman, M. M. (2003). Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q. Proceedings of the National Academy of Sciences, 100(5), 2550- 2555.</mixed-citation>
                    </ref>
                                    <ref id="ref64">
                        <label>64</label>
                        <mixed-citation publication-type="journal">Lohoff, F. W. (2010). Overview of the genetics of major depressive disorder. Current psychiatry reports, 12(6), 539-546.</mixed-citation>
                    </ref>
                                    <ref id="ref65">
                        <label>65</label>
                        <mixed-citation publication-type="journal">Opmeer, E. M., Kortekaas, R., &amp; Aleman, A. (2010). De- pression and the role of genes involved in dopamine metabolism and signalling. Progress in neurobiology, 92(2), 112-133.</mixed-citation>
                    </ref>
                                    <ref id="ref66">
                        <label>66</label>
                        <mixed-citation publication-type="journal">Yuluğ, B., Ozan, E., &amp; Kilic, E. (2010). Brain-derived neurotrophic factor polymorphism as a genetic risk for depression? A short review of the literature. The Journal of neuropsychiatry and clinical neurosciences, 22(1), 123-e5.</mixed-citation>
                    </ref>
                                    <ref id="ref67">
                        <label>67</label>
                        <mixed-citation publication-type="journal">Şengül, C., &amp; Herken, H. (2011). Streste Genetik ve Epigenetik Mekanizmalar. Turkiye Klinikleri Journal of Psychiatry Special Topics, 4(3), 6-12.</mixed-citation>
                    </ref>
                                    <ref id="ref68">
                        <label>68</label>
                        <mixed-citation publication-type="journal">López-León, S., Janssens, A. C. J. W., Ladd, A. G. Z., Del- Favero, J., Claes, S. J., Oostra, B. A., &amp; Van Duijn, C. M. (2007). Meta-analyses of genetic studies on major depressive disorder. Molecular psychiatry, 13(8), 772- 785.</mixed-citation>
                    </ref>
                                    <ref id="ref69">
                        <label>69</label>
                        <mixed-citation publication-type="journal">Schroeder, M., Krebs, M. O., Bleich, S., &amp; Frieling, H. (2010). Epigenetics and depression: current challeng- es and new therapeutic options. Current opinion in psychiatry, 23(6), 588-592.</mixed-citation>
                    </ref>
                                    <ref id="ref70">
                        <label>70</label>
                        <mixed-citation publication-type="journal">Ernst, C., Deleva, V., Deng, X., Sequeira, A., Pomaren- ski, A., Klempan, T., ... &amp; Turecki, G. (2009). Alterna- tive splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Archives of general psychiatry, 66(1), 22-32.</mixed-citation>
                    </ref>
                                    <ref id="ref71">
                        <label>71</label>
                        <mixed-citation publication-type="journal">Haddad, S. K., Reiss, D., Spotts, E. L., Ganiban, J., Li- chtenstein, P., &amp; Neiderhiser, J. M. (2008). Depression and internally directed aggression: genetic and envi- ronmental contributions. Journal of the American Psy- choanalytic Association, 56(2), 515-550.</mixed-citation>
                    </ref>
                                    <ref id="ref72">
                        <label>72</label>
                        <mixed-citation publication-type="journal">Fenichel O. Nevrozların Psikanalitik Teorisi. Ege Üni- versitesi Tıp Fakültesi Kitaplar Serisi No:98 (Çevirmen: Selçuk Tuncer) 1974.</mixed-citation>
                    </ref>
                                    <ref id="ref73">
                        <label>73</label>
                        <mixed-citation publication-type="journal">Taylor, D., &amp; Richardson, P. (2005). The psychoanalyt- ic/psychodynamic approach to depressive disorders. Oxford textbook of psychotherapy, 127-136.</mixed-citation>
                    </ref>
                                    <ref id="ref74">
                        <label>74</label>
                        <mixed-citation publication-type="journal">Brenner, C. (1991). A psychoanalytic perspective on depression. Journal of the American Psychoanalytic Association, 39(1), 25-43.</mixed-citation>
                    </ref>
                                    <ref id="ref75">
                        <label>75</label>
                        <mixed-citation publication-type="journal">Bleichmar, H. B. (1996). Some subtypes of depression and their implications for psychoanalytic treatment. The International journal of psycho-analysis, 77, 935- 961.</mixed-citation>
                    </ref>
                                    <ref id="ref76">
                        <label>76</label>
                        <mixed-citation publication-type="journal">Morley, T. E., &amp; Moran, G. (2011). The origins of cog- nitive vulnerability in early childhood: mechanisms linking early attachment to later depression. Clinical psychology review, 31(7), 1071-1082.</mixed-citation>
                    </ref>
                                    <ref id="ref77">
                        <label>77</label>
                        <mixed-citation publication-type="journal">Bowlby J., (1977). The making and breaking of affec- tional bonds. London, England:Tavistock Publications.</mixed-citation>
                    </ref>
                                    <ref id="ref78">
                        <label>78</label>
                        <mixed-citation publication-type="journal">Ainsworth MS, Blehar MC, Waters E, Wall S., (1978). Patterns of attachment: A psychological study of the strange situation. Oxford, England: Lawrence Erlbaum.</mixed-citation>
                    </ref>
                                    <ref id="ref79">
                        <label>79</label>
                        <mixed-citation publication-type="journal">Dykman, B. M. (1998). Integrating cognitive and mo- tivational factors in depression: initial tests of a goal- orientation approach. Journal of Personality and So- cial psychology, 74(1), 139-158.</mixed-citation>
                    </ref>
                                    <ref id="ref80">
                        <label>80</label>
                        <mixed-citation publication-type="journal">Rusk, N., &amp; Rothbaum, F. (2010). From stress to learn- ing: Attachment theory meets goal orientation theory. Review of General Psychology, 14(1), 31-43.</mixed-citation>
                    </ref>
                                    <ref id="ref81">
                        <label>81</label>
                        <mixed-citation publication-type="journal">Carvalho, J. P., &amp; Hopko, D. R. (2011). Behavioral the- ory of depression: Reinforcement as a mediating vari- able between avoidance and depression. Journal of behavior therapy and experimental psychiatry, 42(2), 154-162.</mixed-citation>
                    </ref>
                                    <ref id="ref82">
                        <label>82</label>
                        <mixed-citation publication-type="journal">Abramson, L. Y., Seligman, M. E., &amp; Teasdale, J. D. (1978). Learned helplessness in humans: critique and reformulation. Journal of abnormal psychology, 87(1), 49-74.</mixed-citation>
                    </ref>
                                    <ref id="ref83">
                        <label>83</label>
                        <mixed-citation publication-type="journal">Beck, A. T. (1967). Depression: Clinical, experimental, and theoretical aspects (Vol. 32). University of Penn- sylvania Press.</mixed-citation>
                    </ref>
                                    <ref id="ref84">
                        <label>84</label>
                        <mixed-citation publication-type="journal">Nolen-Hoeksema, S., Wisco, B. E., &amp; Lyubomirsky, S. (2008). Rethinking rumination. Perspectives on psy- chological science, 3(5), 400-424.</mixed-citation>
                    </ref>
                                    <ref id="ref85">
                        <label>85</label>
                        <mixed-citation publication-type="journal">McEvoy, P. M., Mahoney, A. E., &amp; Moulds, M. L. (2010). Are worry, rumination, and post-event processing one and the same?: Development of the repetitive think- ing questionnaire. Journal of anxiety disorders, 24(5), 509-519.</mixed-citation>
                    </ref>
                                    <ref id="ref86">
                        <label>86</label>
                        <mixed-citation publication-type="journal">Öztürk O., Uluşahin A., (2008). Ruh Sağlığı ve Bozuklukları, yenilenmiş 11. Baskı, cilt 1, Ankara.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
