Propofolün Yan Etkileri: Kaşıntı ve Epilepsi
Yıl 2015,
Cilt: 5 Sayı: 1, 51 - 53, 04.03.2015
Murat Parpucu
Elif Şenses
Öz
Kısa etki süresi ve ender yan etkileri nedeniyle propofol özellikle günübirlik cerrahide yaygın kullanılan bir anesteziktir. . Propofol uygulaması sonrası gelişen anormal hasta hareketleri ve nöbet benzeri aktiviteler bildirilmiştir. Propofol ile indüksiyonu yapılan elektif tüp ligasyonu planlanmış 28 yaşındaki kadın hastada indüksiyon amaçlı propofolün tamamı intravenöz (IV) olarak yavaş yavaş verildikten hemen sonra baş boyun bölgesinde sanki boyunda kaşıntı varmış gibi hızlı ritmik şekilde başın sağa sola hareketleri başladı. Operasyondan sonra hasta serviste sorgulandığında omuzlarından başlayan tüm boynu çene altına kadar kapsayan şiddetli bir kaşıntı hissettiğini belirtti. Biz bu olgu sunumunda, kaşıntı ile birlikte fokal bir bölgede ritmik istenmeyen hareketleri tartışmak istedik.
Kaynakça
- Jungheinrich C,Scharpf R, Wargenau M,Dilger C,Bepperling F.Pharmacokinetics of the generic formulation propofol % 1 fresenius in comparision with the original formulation(Disoprivan %1)Clin Drug Investig 2002;22:417-27.
- Walder B, Tramer MR,Seeck M.Seizure-like phenomena and propofol: a systematic review. Neurology 2002;58:1327-32)
- Borgeat A. Propofol: pro- or anticonvulsant? Eur J Anaesthesiol 1997;14(Suppl 15):17-20.
- Cooms TR, Smith SW. Successfully use of propofol in refractory delirium tremens. Ann Emerg Med 1997;30:825-8.
- Manikandan S, Sinha PK, Neema PK, Rathod RC. Severe seizures during propofol induction in a patient with syringomyelia receiving baclofen. Anesth Analg 2005;100:1468-9.
- Walder B, Tramer MR, Seeck M. Seizure-like phenomena and propofol. A systematic review. Neurology 2002;58:1327-32.
- McNeir, D.A., E.G. Mainous, and N. Trieger, Propofol as an intravenous agent in general anesthesia and conscious sedation. Anesth Prog, 1988. 35(4): p. 147-51.
- Hannallah, R.S., et al., Propofol: effective dose and induction characteristics in unpremedicated children. Anesthesiology, 1991. 74(2): p. 217-9.
- Machata, A.M., et al., Propofol-based sedation regimen for infants and children undergoing ambulatory magnetic resonance imaging. Br J Anaesth, 2008. 101(2): p. 239-43.
- Manikandan S, Sinha PK, Neema PK, Rathod RC. Severe seizures during propofol induction in a patient with syringomyelia receiving baclofen. Anesth Analg 2005;100:1468-9.
- Bendiksen A, Larsen LM. Convulsions, ataxia and hallucinations following propofol. Acta Anaesthesiol Scand 1998;42:739-41. http://dx.doi.org/10.1111/j.1399-6576.1998.tb05312.x PMid:9689285
- Nimmaanrat S. Myoclonic Movements Follwing Induction of Anesthesia with Propofol: A Case Report. J Med Assoc Thai 2005;88:1955-7. PMid:16519000
- Stecker MM, Kramer TH, Raps EC, Skaar DJ. Treatment of refractory status epilepticus with propofol:clinical and pharmacokinetic findings. Epilepsia 1998; 39: 18-26.
- Leikin JB, Benigno J, Dubow JS, Fisher M. Status epilepticus due to tiagabine digestion. Am J Ther 2008; 15: 290-2.
- Iselin-Chaves IA, Grötzsch H, Besson M, Burkhard PR, Savoldelli GL. Naloxone-responsive acute dystonia and parkinsonism following general anaesthesia. Anaesthesia 2009;64:1359- 62. http://dx.doi.org/10.1111/j.1365-2044.2009. 06068.x
- Saravanakumar K, Venkatesh P, Bromley P. Delayed onset refractory dystonic movements following propofol anesthesia. Pediatric Anaesth 2005;1:597-601.http://dx.doi.org/10.1111/j.1460-9592.2005. 01493.x PMid:15960645
- Strachan AN, Raithatha HH. Comment on:Propofol myoclonus. Can J Anaesth 1996;43:536-7. http://dx.doi.org/10.1007/BF03018121 PMid:8723864
- Brooks DE. Propofol-induced movement disorders. Ann Emerg Med 2008;51:111-2. http://dx.doi.org/10.1016/j.annemergmed. 2007.08.023 PMid:18166444
- Islander G, Vinge E. Severe neuroexcitatory symptoms after anaesthesia - with focus on propofol anaesthesia. Acta Anaesthesiol Scand 2000;44:144-9. http://dx.doi.org/10.1034/j.1399-6576.2000. 440203
Side Effects Of Propofol:Itching And Epilepsy
Yıl 2015,
Cilt: 5 Sayı: 1, 51 - 53, 04.03.2015
Murat Parpucu
Elif Şenses
Öz
Propofol with anesthesia is widely used especially for short duration of action and rare side effects of especially in day surgery. Patients with an abnormal movements after propofol administration and seizure-like activity have been reported.Induction with propofol for elective tubal ligation 28-year-old female patient after administration of propofol intravenously slowly redness in the head and neck region and the fast rhythmic movements of the head fro occurred.Patient go to after surgery service that we see covering all the neck under the chin stated that he felt a severe itching. In the present study we wanted to discuss along with itching in a focal region with rhythmic unwanted movements.
Kaynakça
- Jungheinrich C,Scharpf R, Wargenau M,Dilger C,Bepperling F.Pharmacokinetics of the generic formulation propofol % 1 fresenius in comparision with the original formulation(Disoprivan %1)Clin Drug Investig 2002;22:417-27.
- Walder B, Tramer MR,Seeck M.Seizure-like phenomena and propofol: a systematic review. Neurology 2002;58:1327-32)
- Borgeat A. Propofol: pro- or anticonvulsant? Eur J Anaesthesiol 1997;14(Suppl 15):17-20.
- Cooms TR, Smith SW. Successfully use of propofol in refractory delirium tremens. Ann Emerg Med 1997;30:825-8.
- Manikandan S, Sinha PK, Neema PK, Rathod RC. Severe seizures during propofol induction in a patient with syringomyelia receiving baclofen. Anesth Analg 2005;100:1468-9.
- Walder B, Tramer MR, Seeck M. Seizure-like phenomena and propofol. A systematic review. Neurology 2002;58:1327-32.
- McNeir, D.A., E.G. Mainous, and N. Trieger, Propofol as an intravenous agent in general anesthesia and conscious sedation. Anesth Prog, 1988. 35(4): p. 147-51.
- Hannallah, R.S., et al., Propofol: effective dose and induction characteristics in unpremedicated children. Anesthesiology, 1991. 74(2): p. 217-9.
- Machata, A.M., et al., Propofol-based sedation regimen for infants and children undergoing ambulatory magnetic resonance imaging. Br J Anaesth, 2008. 101(2): p. 239-43.
- Manikandan S, Sinha PK, Neema PK, Rathod RC. Severe seizures during propofol induction in a patient with syringomyelia receiving baclofen. Anesth Analg 2005;100:1468-9.
- Bendiksen A, Larsen LM. Convulsions, ataxia and hallucinations following propofol. Acta Anaesthesiol Scand 1998;42:739-41. http://dx.doi.org/10.1111/j.1399-6576.1998.tb05312.x PMid:9689285
- Nimmaanrat S. Myoclonic Movements Follwing Induction of Anesthesia with Propofol: A Case Report. J Med Assoc Thai 2005;88:1955-7. PMid:16519000
- Stecker MM, Kramer TH, Raps EC, Skaar DJ. Treatment of refractory status epilepticus with propofol:clinical and pharmacokinetic findings. Epilepsia 1998; 39: 18-26.
- Leikin JB, Benigno J, Dubow JS, Fisher M. Status epilepticus due to tiagabine digestion. Am J Ther 2008; 15: 290-2.
- Iselin-Chaves IA, Grötzsch H, Besson M, Burkhard PR, Savoldelli GL. Naloxone-responsive acute dystonia and parkinsonism following general anaesthesia. Anaesthesia 2009;64:1359- 62. http://dx.doi.org/10.1111/j.1365-2044.2009. 06068.x
- Saravanakumar K, Venkatesh P, Bromley P. Delayed onset refractory dystonic movements following propofol anesthesia. Pediatric Anaesth 2005;1:597-601.http://dx.doi.org/10.1111/j.1460-9592.2005. 01493.x PMid:15960645
- Strachan AN, Raithatha HH. Comment on:Propofol myoclonus. Can J Anaesth 1996;43:536-7. http://dx.doi.org/10.1007/BF03018121 PMid:8723864
- Brooks DE. Propofol-induced movement disorders. Ann Emerg Med 2008;51:111-2. http://dx.doi.org/10.1016/j.annemergmed. 2007.08.023 PMid:18166444
- Islander G, Vinge E. Severe neuroexcitatory symptoms after anaesthesia - with focus on propofol anaesthesia. Acta Anaesthesiol Scand 2000;44:144-9. http://dx.doi.org/10.1034/j.1399-6576.2000. 440203