Role of Apolipoproteins in Neurodegenerative Diseases

Pınar Kaçamak; Çiğdem Elmas

doi:10.59124/guhes.1383395

EN

Role of Apolipoproteins in Neurodegenerative Diseases

Abstract

Since lipids are insoluble in water, they are carried in the blood as particles called lipoproteins. Lipoproteins consisting of lipids and proteins are multicomponent complexes. The classification of lipoproteins, which are divided into several main groups such as low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL) and chylomicrons, is based on their density, size, lipid and apolipoprotein content. Apolipoproteins are the protein component of lipoproteins that carry lipids from the blood to various tissues of the body for metabolism and utilisation. Apolipoproteins play an important role in lipid metabolism. They regulate many metabolic enzymes and interact with lipoprotein receptors. Numerous studies have shown that apolipoprotein phenotype, different allelic polymorphism and apolipoprotein gene mutation can affect metabolism and utilisation of blood lipids and consequently trigger the onset and development of atherosclerosis, hyperlipidaemia, cerebrovascular and cardiovascular diseases. Furthermore, apolipoproteins have been associated with neurodegenerative diseases and different apolipoprotein polymorphisms have been evaluated as risk factors or protective agents in different neurodegenerative diseases. This review presents evidence from some studies linking apolipoproteins with Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration disease.

Keywords

Alzheimer's disease, Apolipoprotein, Multiple sclerosis, Neurodegeneration, Parkinson's disease

References

Aarsland, D., Andersen, K., Larsen, J. P., & Lolk, A. (2003). Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study. Archives of neurology, 60(3), 387-392. https://doi.org/10.1001/archneur.60.3.387
Adunsky, A., Chesnin, V., Davidson, M., Gerber, Y., Alexander, K., & Haratz, D. (2002). A cross-sectional study of lipids and ApoC levels in Alzheimer's patients with and without cardiovascular disease. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 57(11), M757-M761. https://doi.org/10.1093/gerona/57.11.m757
Antonios, N., Angiolillo, D. J., & Silliman, S. (2008). Hypertriglyceridemia and ischemic stroke. European neurology, 60(6), 269-278. https://doi.org/10.1159/000157880
Bahrami, A., Barreto, G. E., Lombardi, G., Pirro, M., & Sahebkar, A. (2019). Emerging roles for high‐density lipoproteins in neurodegenerative disorders. BioFactors, 45(5), 725-739. https://doi.org/10.1002/biof.1541
Balazs, Z., Panzenboeck, U., Hammer, A., Sovic, A., Quehenberger, O., Malle, E., & Sattler, W. (2004). Uptake and transport of high‐density lipoprotein (HDL) and HDL‐associated α‐tocopherol by an in vitro blood–brain barrier model. Journal of neurochemistry, 89(4), 939-950. https://doi.org/10.1111/j.1471-4159.2004.02373.x
Bergt, C., Nakano, T., Ditterich, J., DeCarli, C., & Eiserich, J. P. (2006). Oxidized plasma high-density lipoprotein is decreased in Alzheimer's disease. Free Radical Biology and Medicine, 41(10), 1542-1547. https://doi.org/10.1016/j.freeradbiomed.2006.08.019
Björkhem, I., & Meaney, S. (2004). Brain cholesterol: long secret life behind a barrier. Arteriosclerosis, thrombosis, and vascular biology, 24(5), 806-815. https://doi.org/10.1161/01.ATV.0000120374.59826.1b.
Brown, M. S., & Goldstein, J. L. (1986). A receptor-mediated pathway for cholesterol homeostasis. Science, 232(4746), 34-47. https://doi.org/10.1126/science.3513311
Browne, R. W., Weinstock-Guttman, B., Horakova, D., Zivadinov, R., Bodziak, M. L., Tamaño-Blanco, M., Badgett, D., Tyblova, M., Vaneckova, M., Seidl, Z., Krasensky, J., Bergsland, N., Ramasamy, D. P., Hagemeier, J., Havrdova, E., & Ramanathan, M. (2014). Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes. Journal of Neurology, Neurosurgery & Psychiatry, 85(8), 859-864. https://doi.org/10.1136/jnnp-2013-307106
Calero, M., Rostagno, A., Matsubara, E., Zlokovic, B., Frangione, B., & Ghiso, J. (2000). Apolipoprotein J (clusterin) and Alzheimer's disease. Microscopy research and technique, 50(4), 305-315. https://doi.org/10.1002/1097-0029(20000815)50:4<305::AID-JEMT10>3.0.CO;2-L

Chang, K. H., Cheng, M. L., Lo, C. J., Fan, C. M., Wu, Y. R., & Chen, C. M. (2023). Alternations of Lipoprotein Profiles in the Plasma as Biomarkers of Huntington’s Disease. Cells, 12(3), 385. https://doi.org/10.3390/cells12030385
Choi, H. J., Byun, M. S., Yi, D., Choe, Y. M., Sohn, B. K., Baek, H. W., Lee, J. H., Kim, H. J., Han, J. Y., Yoon, E. J., Kim, Y. K., Woo, J. I., & Lee, D. Y. (2016). Association between serum triglycerides and cerebral amyloidosis in cognitively normal elderly. The American Journal of Geriatric Psychiatry, 24(8), 604-612. https://doi.org/10.1016/j.jagp.2016.03.001
Dai, L., Li, S., Hao, Q., Zhou, R., Zhou, H., Lei, W., Kang, H., Wu, H., Li, Y., & Ma, X. (2023). Low-density lipoprotein: a versatile nanoscale platform for targeted delivery. Nanoscale Advances, 5, 1011-1022. https://doi.org/10.1039/d2na00883a
Dominiczak, M. H., & Caslake, M. J. (2011). Apolipoproteins: metabolic role and clinical biochemistry applications. Annals of clinical biochemistry, 48(6), 498-515. https://doi.org/10.1258/acb.2011.011111
Eiselein, L., Wilson, D. W., Lamé, M. W., & Rutledge, J. C. (2007). Lipolysis products from triglyceride-rich lipoproteins increase endothelial permeability, perturb zonula occludens-1 and F-actin, and induce apoptosis. American Journal of Physiology-Heart and Circulatory Physiology, 292(6), H2745-H2753. https://doi.org/10.1152/ajpheart.00686.2006
Fang, F., Zhan, Y., Hammar, N., Shen, X., Wirdefeldt, K., Walldius, G., & Mariosa, D. (2019). Lipids, Apolipoproteins, and the risk of Parkinson disease: a prospective cohort study and a Mendelian randomization analysis. Circulation Research, 125(6), 643-652. https://doi.org/10.1161/CIRCRESAHA.119.314929
Fanning, A. S., & Anderson, J. M. (2009). Zonula occludens‐1 and‐2 are cytosolic scaffolds that regulate the assembly of cellular junctions. Annals of the new York Academy of Sciences, 1165(1), 113-120. https://doi.org/10.1111/j.1749-6632.2009.04440.x
Farrer, L. A., Cupples, L. A., Haines, J. L., Hyman, B., Kukull, W. A., Mayeux, R., Myers, R. H., Pericak-Vance, M. A., Risch, N., & Van Duijn, C. M. (1997). Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. Jama, 278(16), 1349-1356. https://doi.org/10.1001/jama.1997.03550160069041
Foster, E. M., Dangla-Valls, A., Lovestone, S., Ribe, E. M., & Buckley, N. J. (2019). Clusterin in Alzheimer’s disease: mechanisms, genetics, and lessons from other pathologies. Frontiers in neuroscience, 13, 164. https://doi.org/10.3389/fnins.2019.00164
Fyfe-Desmarais, G., Desmarais, F., Rassart, É., & Mounier, C. (2023). Apolipoprotein D in Oxidative Stress and Inflammation. Antioxidants, 12(5), 1027. https://doi.org/10.3390/antiox12051027
Gomperts, S. N., Locascio, J. J., Rentz, D., Santarlasci, A., Marquie, M., Johnson, K. A., & Growdon, J. H. (2013). Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia. Neurology, 80(1), 85-91. https://doi.org/10.1212/WNL.0b013e31827b1a07
Hely, M. A., Reid, W. G., Adena, M. A., Halliday, G. M., & Morris, J. G. (2008). The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Movement disorders, 23(6), 837-844. https://doi.org/10.1002/mds.21956
Hong, S., Prokopenko, D., Dobricic, V., Kilpert, F., Bos, I., Vos, S. J., Tijms, B. M., Andreasson, U., Blennow, K., Vandenberghe, R., Cleynen, I., Gabel, S., Schaeverbeke, J., Scheltens, P., Teunissen, C. E., Niemantsverdriet, E., Engelborghs, S., Frisoni, G., Blin, O., … & Bertram, L. (2020). Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset. Translational psychiatry, 10(1), 403. https://doi.org/10.1038/s41398-020-01074-z
Huang, X., Chen, P. C., & Poole, C. (2004). APOE-ε2 allele associated with higher prevalence of sporadic Parkinson disease. Neurology, 62(12), 2198-2202. https://doi.org/10.1212/01.WNL.0000130159.28215.6A
Huang, Y. C., Wu, Y. R., Tseng, M. Y., Chen, Y. C., Hsieh, S. Y., & Chen, C. M. (2011). Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. PloS one, 6(1), e15809. https://doi.org/10.1371/journal.pone.0015809
Hughes, T. A., Ross, H. F., Musa, S., Bhattacherjee, S., Nathan, R. N., Mindham, R. H. S., & Spokes, E. G. S. (2000). A 10-year study of the incidence of and factors predicting dementia in Parkinson’s disease. Neurology, 54(8), 1596-1603. https://doi.org/10.1212/wnl.54.8.1596
Johansson, P., Almqvist, E. G., Bjerke, M., Wallin, A., Johansson, J. O., Andreasson, U., Blennow, K., Zetterberg, H., & Svensson, J. (2017). Reduced cerebrospinal fluid concentration of apolipoprotein AI in patients with Alzheimer’s disease. Journal of Alzheimer's Disease, 59(3), 1017-1026. https://doi.org/10.3233/JAD-170226
Kawano, M., Kawakami, M., Otsuka, M., Yashima, H., Yaginuma, T., & Ueki, A. (1995). Marked decrease of plasma apolipoprotein AI and AII in Japanese patients with late-onset non-familial Alzheimer's disease. Clinica chimica acta; international journal of clinical chemistry, 239(2), 209-211. https://doi.org/10.1016/0009-8981(95)06115-t
Kim, W. S., He, Y., Phan, K., Ahmed, R. M., Rye, K. A., Piguet, O., Hodges, J. R., & Halliday, G. M. (2018). Altered high density lipoprotein composition in behavioral variant frontotemporal dementia. Frontiers in neuroscience, 12, 847. https://doi.org/10.3389/fnins.2018.00847
Koizumi, K., Hattori, Y., Ahn, S. J., Buendia, I., Ciacciarelli, A., Uekawa, K., Wang, G., Hiller, A., Zhao, L., Voss, H. U., Paul, S. M., Schaffer, C., Park, L., & Iadecola, C. (2018). Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function. Nature communications, 9(1), 3816. https://doi.org/10.1038/s41467-018-06301-2
Kuriyama, M., Takahashi, K., Yamano, T., Hokezu, Y., Togo, S., Osame, M., & Igakura, T. (1994). Low levels of serum apolipoprotein AI and AII in senile dementia. Psychiatry and Clinical Neurosciences, 48(3), 589-593. https://doi.org/10.1111/j.1440-1819.1994.tb03019.x
Leduc, M. S., Shimmin, L. C., Klos, K. L., Hanis, C., Boerwinkle, E., & Hixson, J. E. (2008). Comprehensive evaluation of apolipoprotein H gene (APOH) variation identifies novel associations with measures of lipid metabolism in GENOA* s⃞. Journal of lipid research, 49(12), 2648-2656. https://doi.org/10.1194/jlr.M800155-JLR200
Lehnert, S., Jesse, S., Rist, W., Steinacker, P., Soininen, H., Herukka, S. K., Tumani, H., Lenter, M., Oeckl, P., Ferger, B., Hengerer, B., & Otto, M. (2012). iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia. Experimental neurology, 234(2), 499-505. https://doi.org/10.1016/j.expneurol.2012.01.024
Lenzi, C., Ramazzina, I., Russo, I., Filippini, A., Bettuzzi, S., & Rizzi, F. (2020). The down-regulation of clusterin expression enhances the αsynuclein aggregation process. International Journal of Molecular Sciences, 21(19), 7181. https://doi.org/10.3390/ijms21197181
Leoni, E., Bremang, M., Mitra, V., Zubiri, I., Jung, S., Lu, C. H., Adiutori, R., Lombardi, V., Russell, C., Koncarevic, S., Ward, M., Pike, I., & Malaspina, A. (2019). Combined tissue-fluid proteomics to unravel phenotypic variability in amyotrophic lateral sclerosis. Scientific Reports, 9(1), 4478. https://doi.org/10.1038/s41598-019-40632-4
Lin, Y., Lu, L., Zhou, M., Liu, H., Ye, P., Zhang, W., Qiu, J., Zhang, Z., Yang, X., Ding, L., Guo, W., Mo, M., Zhu, X., Zhang, X., Chen, X., & Xu, P. (2021). Association of CLU gene polymorphism with Parkinson's disease in the Chinese Han population. The Journal of Gene Medicine, 23(2), e3302. https://doi.org/10.1002/jgm.3302
Liu, H. C., Hu, C. J., Chang, J. G., Sung, S. M., Lee, L. S., Yuan, R. Y., & Leu, S. J. (2006). Proteomic identification of lower apolipoprotein AI in Alzheimer’s disease. Dementia and geriatric cognitive disorders, 21(3), 155-161. https://doi.org/10.1159/000090676
Liu, T., Chen, J. M., Zhang, D., Zhang, Q., Peng, B., Xu, L., & Tang, H. (2021). ApoPred: identification of apolipoproteins and their subfamilies with multifarious features. Frontiers in Cell and Developmental Biology, 8, 621144. https://doi.org/10.3389/fcell.2020.621144
Maarouf, C. L., Beach, T. G., Adler, C. H., Shill, H. A., Sabbagh, M. N., Wu, T., Walker, D. G., Kokjohn, T. A., Roher, A. E., & Consortium, A. P. (2012). Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson’s disease subjects. Neurological research, 34(7), 669-676. https://doi.org/10.1179/1743132812Y.0000000063
Mata , I. F., Leverenz, J. B., Weintraub, D., Trojanowski, J. Q., Hurtig, H. I., Van Deerlin, V. M., Ritz, B., Rausch, R., Rhodes, S. L., Factor, S. A., Wood-Siverio, C., Quinn, J. F., Chung, K. A., Peterson, A. L., Espay, A. J., Revilla, F. J., Devoto, J., Hu, S., Cholerton, B. A., Wan, J. Y., Montine, T. J., Edwards, K. L., & Zabetian, C. P. (2014). APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease. JAMA neurology, 71(11), 1405-1412. https://doi.org/10.1001/jamaneurol.2014.1455
Mathieu, C., Pappu, R. V., & Taylor, J. P. (2020). Beyond aggregation: Pathological phase transitions in neurodegenerative disease. Science, 370(6512), 56-60. https://doi.org/10.1126/science.abb8032
Merched , A., Xia, Y., Visvikis, S., Serot, J. M., & Siest, G. (2000). Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer’s disease☆. Neurobiology of aging, 21(1), 27-30. https://doi.org/10.1016/s0197-4580(99)00103-7
McComb, M., Parambi, R., Browne, R. W., Bodziak, M. L., Jakimovski, D., Bergsland, N., Maceski, A., Weinstock-Guttman, B., Jens Kuhle, J., Zivadinov, R., & Ramanathan, M. (2020). Apolipoproteins AI and E are associated with neuroaxonal injury to gray matter in multiple sclerosis. Multiple sclerosis and related disorders, 45, 102389. https://doi.org/10.1016/j.msard.2020.102389
Misra, A., Chakrabarti, S. S., Gambhir, I. S., Baghel, M. S., & Patil, Y. R. (2021). Tandem mass spectrometry-based identification of protein profiles in the cerebrospinal fluid of Alzheimer’s dementia patients. https://doi.org/10.21203/rs.3.rs-574644/v1
Muenchhoff, J., Song, F., Poljak, A., Crawford, J. D., Mather, K. A., Kochan, N. A., Yang, Z., Trollor, J. N., Reppermund, S., Maston, K., Theobald, A., Kirchner-Adelhardt, S., Kwok, J. B., Richmond, R. L., McEvoy, M., Attia, J., Schofield, P. W., Brodaty, H., & Sachdev, P. S. (2017). Plasma apolipoproteins and physical and cognitive health in very old individuals. Neurobiology of Aging, 55, 49-60. https://doi.org/10.1016/j.neurobiolaging.2017.02.017
Murali, N., Browne, R. W., Fellows Maxwell, K., Bodziak, M. L., Jakimovski, D., Hagemeier, J., Bergsland, N., Weinstock-Guttman, B., Zivadinov, R., & Ramanathan, M. (2020). Cholesterol and neurodegeneration: longitudinal changes in serum cholesterol biomarkers are associated with new lesions and gray matter atrophy in multiple sclerosis over 5 years of follow‐up. European Journal of Neurology, 27(1), 188-e4. https://doi.org/10.1111/ene.14055
Nakaya, Y., Schaefer, E. J., & Brewer Jr, H. B. (1980). Activation of human post heparin lipoprotein lipase by apolipoprotein H (β2-glycoprotein I). Biochemical and biophysical research communications, 95(3), 1168-1172. https://doi.org/10.1016/0006-291X(80)91595-8
Namba, Y., Tsuchiya, H., & Ikeda, K. (1992). Apolipoprotein B immunoreactivity in senile plaque and vascular amyloids and neurofibrillary tangles in the brains of patients with Alzheimer's disease. Neuroscience letters, 134(2), 264-266. https://doi.org/10.1016/0304-3940(92)90531-b
Navarro, A., Rioseras, B., Del Valle, E., Martínez-Pinilla, E., Astudillo, A., & Tolivia, J. (2018). Expression pattern of myelin-related apolipoprotein D in human multiple sclerosis lesions. Frontiers in Aging Neuroscience, 10, 254. https://doi.org/10.3389/fnagi.2018.00254
Öhrfelt, A., Andreasson, U., Simon, A., Zetterberg, H., Edman, Å., Potter, W., Holder, D., Devanarayan, V., Seeburger, J., Smith, A. D., Blennow, K., & Wallin, A. (2011). Screening for new biomarkers for subcortical vascular dementia and Alzheimer’s disease. Dementia and geriatric cognitive disorders extra, 1(1), 31-42. https://doi.org/10.1159/000323417
Park, J. H., Hong, K. S., Lee, E. J., Lee, J., & Kim, D. E. (2011). High levels of apolipoprotein B/AI ratio are associated with intracranial atherosclerotic stenosis. Stroke, 42(11), 3040-3046. https://doi.org/10.1161/STROKEAHA.111.620104
Paula-Lima, A. C., Tricerri, M. A., Brito-Moreira, J., Bomfim, T. R., Oliveira, F. F., Magdesian, M. H., Grinberg, L. T., Panizzutti, R., & Ferreira, S. T. (2009). Human apolipoprotein A–I binds amyloid-β and prevents Aβ-induced neurotoxicity. The international journal of biochemistry & cell biology, 41(6), 1361-1370. https://doi.org/10.1016/j.biocel.2008.12.003
Přikrylová Vranová, H., Mareš, J., Nevrlý, M., Stejskal, D., Zapletalová, J., Hluštík, P., & Kaňovský, P. (2010). CSF markers of neurodegeneration in Parkinson’s disease. Journal of neural transmission, 117, 1177-1181. https://doi.org/10.1007/s00702-010-0462-z
Ramasamy, I. (2014). Recent advances in physiological lipoprotein metabolism. Clinical Chemistry and Laboratory Medicine (CCLM), 52(12), 1695-1727. https://doi.org/10.1515/cclm-2013-0358
Rassart, E., Bedirian, A., Do Carmo, S., Guinard, O., Sirois, J., Terrisse, L., & Milne, R. (2000). Apolipoprotein d. Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology, 1482(1-2), 185-198. https://doi.org/10.1016/S0167-4838(00)00162-X
Real, R., Martinez-Carrasco, A., Reynolds, R. H., Lawton, M. A., Tan, M. M., Shoai, M., Corvol, J. C., Ryten, M., Bresner, C., Hubbard, L., Brice, A., Lesage, S., Faouzi, J., Elbaz, A., Artaud, F., Williams, N., Hu, M. T. M., Ben-Shlomo, Y., Grosset, D. G., ... & Morris, H. R. (2023). Association between the LRP1B and APOE loci and the development of Parkinson’s disease dementia. Brain, 146(5), 1873-1887. https://doi.org/10.1093/brain/awac414
Reichert, C. O., de Freitas, F. A., Sampaio-Silva, J., Rokita-Rosa, L., Barros, P. D. L., Levy, D., & Bydlowski, S. P. (2020a). Ferroptosis mechanisms involved in neurodegenerative diseases. International journal of molecular sciences, 21(22), 8765. https://doi.org/10.3390/ijms21228765
Reichert, C. O., Levy, D., & Bydlowski, S. P. (2020b). Paraoxonase role in human neurodegenerative diseases. Antioxidants, 10(1), 11. https://doi.org/10.3390/antiox10010011
Reindl, M., Knipping, G., Wicher, I., Dilitz, E., Egg, R., Deisenhammer, F., & Berger, T. (2001). Increased intrathecal production of apolipoprotein D in multiple sclerosis. Journal of neuroimmunology, 119(2), 327-332. https://doi.org/10.1016/s0165-5728(01)00378-2
Richardson, T. G., Sanderson, E., Palmer, T. M., Ala-Korpela, M., Ference, B. A., Davey Smith, G., & Holmes, M. V. (2020). Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis. PLoS medicine, 17(3), e1003062. https://doi.org/10.1371/journal.pmed.1003062
Ross MH, & Pawlina W. (2011). Histology: A text and atlas with correlated cell and molecular biology. Baltimore, Philadelphia: Lippincott Williams & Wilkins.
Saczynski, J. S., White, L., Peila, R. L., Rodriguez, B. L., & Launer, L. J. (2007). The relation between apolipoprotein AI and dementia: the Honolulu-Asia aging study. American journal of epidemiology, 165(9), 985-992. https://doi.org/10.1093/aje/kwm027
Sasaki , K., Doh-ura, K., Wakisaka, Y., & Iwaki, T. (2002). Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with α-synucleinopathies. Acta neuropathologica, 104, 225-230. https://doi.org/10.1007/s00401-002-0546-4
Shih, Y. H., Tsai, K. J., Lee, C. W., Shiesh, S. C., Chen, W. T., Pai, M. C., & Kuo, Y. M. (2014). Apolipoprotein C-III is an amyloid-β-binding protein and an early marker for Alzheimer's disease. Journal of Alzheimer's Disease, 41(3), 855-865. https://doi.org/10.3233/JAD-140111
Su, W. H., Shi, Z. H., Liu, S. L., Wang, X. D., Liu, S., & Ji, Y. (2017). Updated meta-analysis of the role of APOE ε2/ε3/ε4 alleles in frontotemporal lobar degeneration. Oncotarget, 8(27), 43721. https://doi.org/10.18632/oncotarget.17341
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018). Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nature Reviews Neurology, 14(3), 133-150. https://doi.org/10.1038/nrneurol.2017.188
Thompson, A. G., Talbot, K., & Turner, M. R. (2022). Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with reduced risk of developing amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, 93(1), 75-81. https://doi.org/10.1136/jnnp-2021-327133
Tóth, M. E., Dukay, B., Hoyk, Z., & Sántha, M. (2020). Cerebrovascular changes and neurodegeneration related to hyperlipidemia: characteristics of the human ApoB-100 transgenic mice. Current Pharmaceutical Design, 26(13), 1486-1494. https://doi.org/10.2174/1381612826666200218101818
Tsuang, D., Leverenz, J. B., Lopez, O. L., Hamilton, R. L., Bennett, D. A., Schneider, J. A., Buchman, A. S., Larson, E. B., Crane, P. K., Kaye, J. A., Kramer, P., Woltjer, R., Trojanowski, J. O., Weintraub, D., Chen-Plotkin, A. S., Irwin, D. J., Rick, J., Schellenberg, G. D., Watson, G. S., … & Zabetian, C. P. (2013). APOE ϵ4 increases risk for dementia in pure synucleinopathies. JAMA neurology, 70(2), 223-228. https://doi.org/10.1001/jamaneurol.2013.600
Turan, T. N., Makki, A. A., Tsappidi, S., Cotsonis, G., Lynn, M. J., Cloft, H. J., & Chimowitz, M. I. (2010). Risk factors associated with severity and location of intracranial arterial stenosis. Stroke, 41(8), 1636-1640. https://doi.org/10.1161/STROKEAHA.110.584672
van Luijn, M. M., van Meurs, M., Stoop, M. P., Verbraak, E., Wierenga-Wolf, A. F., Melief, M. J., Kreft, K. L., Verdijk, R. M., ’t Hart, B. A., Luider, T. M., Laman, J. D., & Hintzen, R. Q. (2016). Elevated expression of the cerebrospinal fluid disease markers chromogranin a and clusterin in astrocytes of multiple sclerosis white matter lesions. Journal of Neuropathology & Experimental Neurology, 75(1), 86-98. https://doi.org/10.1093/jnen/nlv004
Vitali, C., Wellington, C. L., & Calabresi, L. (2014). HDL and cholesterol handling in the brain. Cardiovascular research, 103(3), 405-413. https://doi.org/10.1093/cvr/cvu148
Waldner, A., Dassati, S., Redl, B., Smania, N., & Gandolfi, M. (2018). Apolipoprotein D concentration in human plasma during aging and in Parkinson’s disease: a cross-sectional study. Parkinson’s Disease, 2018. https://doi.org/10.1155/2018/3751516
Wang, L., Sapuri-Butti, A. R., Aung, H. H., Parikh, A. N., & Rutledge, J. C. (2008). Triglyceride-rich lipoprotein lipolysis increases aggregation of endothelial cell membrane microdomains and produces reactive oxygen species. American Journal of Physiology-Heart and Circulatory Physiology, 295(1), H237-H244. https://doi.org/10.1152/ajpheart.01366.2007
Wei, Q., Wang, H., Tian, Y., Xu, F., Chen, X., & Wang, K. (2013). Reduced serum levels of triglyceride, very low density lipoprotein cholesterol and apolipoprotein B in Parkinson’s disease patients. PLoS One, 8(9), e75743. https://doi.org/10.1371/journal.pone.0075743
Weinstock-Guttman, B., Zivadinov, R., Mahfooz, N., Carl, E., Drake, A., Schneider, J., Teter, B., Hussein, S., Mehta, B., Weiskopf, M., Durfee, J., Bergsland, N., & Ramanathan, M. (2011). Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis. Journal of neuroinflammation, 8(1), 1-7. https://doi.org/10.1186/1742-2094-8-127
Wisniewski, T., Golabek, A. A., Kida, E., Wisniewski, K. E., & Frangione, B. (1995). Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis. The American journal of pathology, 147(2), 238. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1869828/pdf/amjpathol00044-0015.pdf
Zhang, X., & Alzheimer’s Disease Neuroimaging Initiative. (2020). Higher plasma APOC-III was associated with a slower reduction of β-amyloid levels in cerebrospinal fluid among older individuals without dementia. Neuropsychiatric Disease and Treatment, 1139-1144. https://doi.org/10.2147/NDT.S238985
Zhang, X., Yin, X., Yu, H., Liu, X., Yang, F., Yao, J., Jin, H., & Yang, P. (2012). Quantitative proteomic analysis of serum proteins in patients with Parkinson’s disease using an isobaric tag for relative and absolute quantification labeling, two-dimensional liquid chromatography, and tandem mass spectrometry. Analyst, 137(2), 490-495. https://doi.org/10.1039/c1an15551b
Zlokovic, B. V., Martel, C. L., Matsubara, E., McComb, J. G., Zheng, G., McCluskey, R. T., Frangione, B., & Ghiso, J. (1996). Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proceedings of the National Academy of Sciences, 93(9), 4229-4234. https://doi.org/10.1073/pnas.93.9.4229

Details

Primary Language

English

Subjects

Clinical Sciences (Other)

Journal Section

Review

Authors

Pınar Kaçamak ^*
0000-0001-5650-9664
Türkiye

Çiğdem Elmas
0000-0002-8857-0918
Türkiye

Publication Date

December 31, 2023

Submission Date

October 30, 2023

Acceptance Date

December 27, 2023

Published in Issue

Year 2023 Volume: 5 Number: 3

DOI

https://doi.org/10.59124/guhes.1383395

IZ

https://izlik.org/JA29US22NZ

APA

Kaçamak, P., & Elmas, Ç. (2023). Role of Apolipoproteins in Neurodegenerative Diseases. Journal of Gazi University Health Sciences Institute, 5(3), 122-133. https://doi.org/10.59124/guhes.1383395

AMA

1.Kaçamak P, Elmas Ç. Role of Apolipoproteins in Neurodegenerative Diseases. GUHES. 2023;5(3):122-133. doi:10.59124/guhes.1383395

Chicago

Kaçamak, Pınar, and Çiğdem Elmas. 2023. “Role of Apolipoproteins in Neurodegenerative Diseases”. Journal of Gazi University Health Sciences Institute 5 (3): 122-33. https://doi.org/10.59124/guhes.1383395.

EndNote

Kaçamak P, Elmas Ç (December 1, 2023) Role of Apolipoproteins in Neurodegenerative Diseases. Journal of Gazi University Health Sciences Institute 5 3 122–133.

IEEE

[1]P. Kaçamak and Ç. Elmas, “Role of Apolipoproteins in Neurodegenerative Diseases”, GUHES, vol. 5, no. 3, pp. 122–133, Dec. 2023, doi: 10.59124/guhes.1383395.

ISNAD

Kaçamak, Pınar - Elmas, Çiğdem. “Role of Apolipoproteins in Neurodegenerative Diseases”. Journal of Gazi University Health Sciences Institute 5/3 (December 1, 2023): 122-133. https://doi.org/10.59124/guhes.1383395.

JAMA

1.Kaçamak P, Elmas Ç. Role of Apolipoproteins in Neurodegenerative Diseases. GUHES. 2023;5:122–133.

MLA

Kaçamak, Pınar, and Çiğdem Elmas. “Role of Apolipoproteins in Neurodegenerative Diseases”. Journal of Gazi University Health Sciences Institute, vol. 5, no. 3, Dec. 2023, pp. 122-33, doi:10.59124/guhes.1383395.

Vancouver

1.Pınar Kaçamak, Çiğdem Elmas. Role of Apolipoproteins in Neurodegenerative Diseases. GUHES. 2023 Dec. 1;5(3):122-33. doi:10.59124/guhes.1383395

Abstract

Role of Apolipoproteins in Neurodegenerative Diseases

Abstract

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Acceptance Date

Published in Issue

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