Serum Adipsin Levels in Obese and Normal Weight Adolescents with Polycystic Ovary Syndrome

Abstract

Polycystic ovary syndrome (PCOS) is a chronic and heterogeneous disease associated with obesity, hyperinsulinemia, dyslipidemia and chronic low-grade inflammation. Adipsin is a protein that is mostly secreted from adipose tissue and is a structural homolog of complement factor D, the rate-limiting enzyme of the alternative complement system. The aim of this study was to investigate adipsin levels in adolescents with PCOS and their relationship with obesity. 40 normal weight--children with PCOS and 40 obese-children with PCOS, and 40 normal weight healthy children participated in our study. Adipsin levels of adolescents in each group was measured in morning fasting blood samples by a commercial ELISA kit. Adipsin levels showed statistically significant differences between the groups. (p<0.001). Normal-weight PCOS adolescents had higher adipsin levels than both obese PCOS and healthy controls. A negative correlation was observed between adipsin levels and BMI in the PCOS group (r=-0,457, p<0,001). In conclusion, adipsin can be considered as an independent risk factor in normal weight adolescents with PCOS and may help in the diagnosis of PCOS in normal weight children with other symptoms.

Keywords

• adolescent PCOS
• obesity
• adipsin

Obez ve Normal Kilolu Polikistik Over Sendromlu Ergenlerde Serum Adipsin Seviyeleri

Abstract

Polikistik over sendromu (PKOS) obezite, hiperinsülinemi, dislipidemi ve kronik düşük dereceli inflamasyonla ilişkili kronik ve heterojen bir hastalıktır. Adipsin çoğunlukla yağ dokusundan salgılanan bir proteindir ve alternatif tamamlayıcı sistemin hız sınırlayıcı enzimi olan tamamlayıcı faktör D'nin yapısal bir homologudur. Bu çalışmanın amacı PCOS'lu ergenlerde adipsin seviyelerini ve obezite ile ilişkisini araştırmaktır. Çalışmamıza 40 normal kilolu PCOS'lu çocuk ve 40 obez PCOS'lu çocuk ve 40 normal kilolu sağlıklı çocuk katıldı. Her bir gruptaki ergenlerin adipsin seviyeleri sabah açlık kan örneklerinde ticari bir ELISA kiti ile ölçüldü. Adipsin seviyeleri gruplar arasında istatistiksel olarak anlamlı farklılıklar gösterdi (p<0,001). Normal kilolu PCOS'lu ergenlerin adipsin seviyeleri hem obez PCOS'lu hem de sağlıklı kontrollerden daha yüksekti. PCOS grubunda adipsin seviyeleri ile VKİ arasında negatif bir korelasyon gözlendi (r=-0,457, p<0,001). Sonuç olarak adipsinin normal kilolu PKOS'lu ergenlerde bağımsız bir risk faktörü olarak değerlendirilebileceği ve diğer semptomları olan normal kilolu çocuklarda PKOS tanısının konulmasında yardımcı olabileceği düşünülebilir.

Keywords

• adipsin
• Ergen PCOS
• obezite

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