Serum Adipsin Levels in Obese and Normal Weight Adolescents with Polycystic Ovary Syndrome

Çağla Emiral; Derya Buluş; Yüksel Yaşartekin; Sevgi Akaydın

doi:10.59124/guhes.1604306

EN TR

Serum Adipsin Levels in Obese and Normal Weight Adolescents with Polycystic Ovary Syndrome

Abstract

Polycystic ovary syndrome (PCOS) is a chronic and heterogeneous disease associated with obesity, hyperinsulinemia, dyslipidemia and chronic low-grade inflammation. Adipsin is a protein that is mostly secreted from adipose tissue and is a structural homolog of complement factor D, the rate-limiting enzyme of the alternative complement system. The aim of this study was to investigate adipsin levels in adolescents with PCOS and their relationship with obesity. 40 normal weight--children with PCOS and 40 obese-children with PCOS, and 40 normal weight healthy children participated in our study. Adipsin levels of adolescents in each group was measured in morning fasting blood samples by a commercial ELISA kit. Adipsin levels showed statistically significant differences between the groups. (p<0.001). Normal-weight PCOS adolescents had higher adipsin levels than both obese PCOS and healthy controls. A negative correlation was observed between adipsin levels and BMI in the PCOS group (r=-0,457, p<0,001). In conclusion, adipsin can be considered as an independent risk factor in normal weight adolescents with PCOS and may help in the diagnosis of PCOS in normal weight children with other symptoms.

Keywords

adolescent PCOS, obesity, adipsin

Supporting Institution

Gazi University

Project Number

Gazi University Research Fund (Project No: TDK-2023-8311)

Ethical Statement

The study protocol was approved by the Ethical Committe of Gazi University (dated 12.09.2022, ref.no:685)

Obez ve Normal Kilolu Polikistik Over Sendromlu Ergenlerde Serum Adipsin Seviyeleri

Abstract

Polikistik over sendromu (PKOS) obezite, hiperinsülinemi, dislipidemi ve kronik düşük dereceli inflamasyonla ilişkili kronik ve heterojen bir hastalıktır. Adipsin çoğunlukla yağ dokusundan salgılanan bir proteindir ve alternatif tamamlayıcı sistemin hız sınırlayıcı enzimi olan tamamlayıcı faktör D'nin yapısal bir homologudur. Bu çalışmanın amacı PCOS'lu ergenlerde adipsin seviyelerini ve obezite ile ilişkisini araştırmaktır. Çalışmamıza 40 normal kilolu PCOS'lu çocuk ve 40 obez PCOS'lu çocuk ve 40 normal kilolu sağlıklı çocuk katıldı. Her bir gruptaki ergenlerin adipsin seviyeleri sabah açlık kan örneklerinde ticari bir ELISA kiti ile ölçüldü. Adipsin seviyeleri gruplar arasında istatistiksel olarak anlamlı farklılıklar gösterdi (p<0,001). Normal kilolu PCOS'lu ergenlerin adipsin seviyeleri hem obez PCOS'lu hem de sağlıklı kontrollerden daha yüksekti. PCOS grubunda adipsin seviyeleri ile VKİ arasında negatif bir korelasyon gözlendi (r=-0,457, p<0,001). Sonuç olarak adipsinin normal kilolu PKOS'lu ergenlerde bağımsız bir risk faktörü olarak değerlendirilebileceği ve diğer semptomları olan normal kilolu çocuklarda PKOS tanısının konulmasında yardımcı olabileceği düşünülebilir.

Keywords

adipsin, Ergen PCOS, obezite

Project Number

Gazi University Research Fund (Project No: TDK-2023-8311)

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Details

Primary Language

English

Subjects

Clinical Sciences (Other)

Journal Section

Research Article

Authors

Çağla Emiral
0000-0002-5185-9849
Türkiye

Derya Buluş
0000-0003-2865-4420
Türkiye

Yüksel Yaşartekin
0000-0002-5620-8199
Türkiye

Sevgi Akaydın ^*
0000-0002-0927-5188
Türkiye

Publication Date

December 31, 2024

Submission Date

December 20, 2024

Acceptance Date

December 25, 2024

Published in Issue

Year 2024 Volume: 6 Number: 3

DOI

https://doi.org/10.59124/guhes.1604306

IZ

https://izlik.org/JA47TB98ZW

APA

Emiral, Ç., Buluş, D., Yaşartekin, Y., & Akaydın, S. (2024). Serum Adipsin Levels in Obese and Normal Weight Adolescents with Polycystic Ovary Syndrome. Journal of Gazi University Health Sciences Institute, 6(3), 107-116. https://doi.org/10.59124/guhes.1604306

AMA

1.Emiral Ç, Buluş D, Yaşartekin Y, Akaydın S. Serum Adipsin Levels in Obese and Normal Weight Adolescents with Polycystic Ovary Syndrome. GUHES. 2024;6(3):107-116. doi:10.59124/guhes.1604306

Chicago

Emiral, Çağla, Derya Buluş, Yüksel Yaşartekin, and Sevgi Akaydın. 2024. “Serum Adipsin Levels in Obese and Normal Weight Adolescents With Polycystic Ovary Syndrome”. Journal of Gazi University Health Sciences Institute 6 (3): 107-16. https://doi.org/10.59124/guhes.1604306.

EndNote

Emiral Ç, Buluş D, Yaşartekin Y, Akaydın S (December 1, 2024) Serum Adipsin Levels in Obese and Normal Weight Adolescents with Polycystic Ovary Syndrome. Journal of Gazi University Health Sciences Institute 6 3 107–116.

IEEE

[1]Ç. Emiral, D. Buluş, Y. Yaşartekin, and S. Akaydın, “Serum Adipsin Levels in Obese and Normal Weight Adolescents with Polycystic Ovary Syndrome”, GUHES, vol. 6, no. 3, pp. 107–116, Dec. 2024, doi: 10.59124/guhes.1604306.

ISNAD

Emiral, Çağla - Buluş, Derya - Yaşartekin, Yüksel - Akaydın, Sevgi. “Serum Adipsin Levels in Obese and Normal Weight Adolescents With Polycystic Ovary Syndrome”. Journal of Gazi University Health Sciences Institute 6/3 (December 1, 2024): 107-116. https://doi.org/10.59124/guhes.1604306.

JAMA

1.Emiral Ç, Buluş D, Yaşartekin Y, Akaydın S. Serum Adipsin Levels in Obese and Normal Weight Adolescents with Polycystic Ovary Syndrome. GUHES. 2024;6:107–116.

MLA

Emiral, Çağla, et al. “Serum Adipsin Levels in Obese and Normal Weight Adolescents With Polycystic Ovary Syndrome”. Journal of Gazi University Health Sciences Institute, vol. 6, no. 3, Dec. 2024, pp. 107-16, doi:10.59124/guhes.1604306.

Vancouver

1.Çağla Emiral, Derya Buluş, Yüksel Yaşartekin, Sevgi Akaydın. Serum Adipsin Levels in Obese and Normal Weight Adolescents with Polycystic Ovary Syndrome. GUHES. 2024 Dec. 1;6(3):107-16. doi:10.59124/guhes.1604306

Serum Adipsin Levels in Obese and Normal Weight Adolescents with Polycystic Ovary Syndrome

Abstract

Keywords

Supporting Institution

Project Number

Ethical Statement

Obez ve Normal Kilolu Polikistik Over Sendromlu Ergenlerde Serum Adipsin Seviyeleri

Abstract

Keywords

Project Number

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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