Thiol-Disulphide Homeostasis and Coagulopathy in Covid-19 Patients

Year 2025, Volume: 7 Issue: 3, 105 - 113, 29.12.2025

Aysun Hacışevki , Turgut Kaya

https://doi.org/10.59124/guhes.1818699

Abstract

Since the beginning of the 21st century, several infectious disease outbreaks have occurred worldwide, posing serious threats to global health. Among these, the COVID-19 pandemic, which emerged in late 2019, caused millions of deaths and severe strain on healthcare systems. Beyond its respiratory manifestations, COVID-19 has been closely associated with systemic complications, particularly coagulopathy, which represents a major determinant of morbidity and mortality. Coagulopathy in COVID-19 involves abnormal activation of coagulation pathways, leading to microvascular thrombosis and thromboembolic events such as deep vein thrombosis and pulmonary embolism. These complications contribute to hypoxia, multi-organ failure, and increased mortality rates. The mechanisms underlying this hypercoagulable state include endothelial dysfunction, excessive inflammation, oxidative stress, and immune imbalance. A growing body of evidence highlights the crucial role of thiol–disulphide homeostasis in preserving redox balance and vascular integrity. Under oxidative stress, the excessive generation of reactive oxygen species (ROS) alters the thiol–disulphide equilibrium, impairing protein structure and endothelial function. In COVID-19, this imbalance amplifies inflammatory and prothrombotic responses, exacerbating coagulopathy. This review discusses the interplay between coagulopathy and thiol–disulphide homeostasis in COVID-19, emphasizing how redox imbalance contributes to thrombogenesis. Understanding these mechanisms may provide novel insights into potential biomarkers and therapeutic strategies aimed at restoring oxidative balance and preventing thrombotic complications in patients with severe COVID-19.

Keywords

coagulopathy , COVID-19 , endothelial dysfunction , oxidative stress , thiol–disulphide , homeostasis

Ethical Statement

This study is a review study, so it does not require ethics committee approval. However, it was conducted in accordance with ethical principles.

Supporting Institution

No financial support was received for this study.

Project Number

-

Thanks

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