The Role of Hypoxia in Periodontal Diseases

Abstract

Environmental and genetic factors are effective in influencing the progression of periodontal diseases that are chronic in nature and are triggered by dysbiotic oral microbiota. Periodontal infection and inflammation are accompanied by hypoxia which is the pathological depletion of oxygen in generalized or localized tissues. Hypoxia, increases the rate of periodontal disease progression and creates related hypoxic changes in periodontal inflammation. Hypoxic changes in tissues are primarily the result of the transcriptional regulatory proteins and hypoxia induced factors. Recently, clinical studies about the relationship between hypoxia and periodontal diseases have been gaining importance throughout the literature. In the present review, we aimed to summarize the association of hypoxia and periodontal disease, depending on the evidence presented in the recent literature.

Keywords

• Periodontal diseases
• hypoxia
• inflammation

References

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