Generalized Tonic-Clonic Seizure Due to the Concomitant Use of Bupropion Extended-Release and Moxifloxacin

Yıl 2019, Cilt: 1 Sayı: 1, 28 - 31, 15.12.2019

Mehmet Hamdi Orum

Öz

Bupropion extended-release (XL), an amphetamine-like dual
mechanism drug, is used for the treatment of major depressive disorder, and its
use is associated with a dose-dependent risk of epileptic seizures.
Moxifloxacin is synthetic fluoroquinolone antibiotic agent which has
proconvulsant side effects. Although there is no drug-drug interaction between
these two drugs, their concomitant use can trigger epilepsy. In this report, we
discussed a male patient using bupropion XL, who developed generalized
tonic-clonic seizure after treatment with moxifloxacin and had no history of
seizures. The association of bupropion XL with catecholamines and the
association of both bupropion XL and moxifloxacin with gamma aminobutyric acid
were possible accused mechanisms. This
case report suggests physicians to pay attention to the
potential risk of bupropion XL- and moxifloxacin-induced seizures.

Anahtar Kelimeler

Bupropion Extended-Release, Moxifloxacin, Seizure, Side Effect

Kaynakça

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