Yıl 2020, Cilt 2 , Sayı 1, Sayfalar 18 - 27 2020-04-30

The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body

Emine ELİBOL [1] , Yasemin AKDEVELİOĞLU [2]


Discovered as the endogenous ligand of the growth hormone secretagogue receptor, the ghrelin hormone is a small 28-amino acid peptide. This hormone is produced by certain tissues of the stomach, the brain, the liver, the kidneys, the pancreas, the pituitary gland, and adipose tissue. Major forms of ghrelin in plasma are acyl and desacyl ghrelin. While decacyl ghrelin was first thought to be an intermediate or degradation product of acyl ghrelin, today it has been found that desacyl ghrelin has metabolic effects on the body as a separate hormone. For this reason, this review was made to evaluate the effects of acyl and desacyl ghrelin on the body. Ghrelin causes a biological effect by binding to the growth hormone secretogogue receptors in the body. Only the acyl ghrelin hormone can bind to the growth hormone secretagogue receptor 1a. Des acyl cannot bind. As a result of studies, it has been determined that acyl ghrelin has an effect on appetite increase, growth hormone release, in addition to body weight and insulin resistance. Desacyl ghrelin has an effect on appetite decreas, body weight, as well as increase in insulin sensitivity. Moreover, it has been emphasized in recent years that desacyl ghrelin may be a strong inhibitor of the acyl ghrelin hormone. However, the effects of these two hormones in some patients are not fully understood. Therefore, studies investigating the effects of these hormones on different diseases should be conducted in the future.
ghrelin, acyl ghrelin, desacyl ghrelin, disease
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Birincil Dil en
Konular Beslenme ve Diyetetik
Bölüm Makaleler
Yazarlar

Yazar: Emine ELİBOL (Sorumlu Yazar)
Kurum: Ankara Yıldırım Beyazıt Üniversitesi
Ülke: Turkey


Yazar: Yasemin AKDEVELİOĞLU
Kurum: Gazı University
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 30 Nisan 2020

Bibtex @derleme { guhes701814, journal = {Journal of Gazi University Health Sciences Institute}, issn = {2687-6353}, address = {guhes@gazi.edu.tr}, publisher = {Gazi Üniversitesi}, year = {2020}, volume = {2}, pages = {18 - 27}, doi = {}, title = {The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body}, key = {cite}, author = {Eli̇bol, Emine and Akdeveli̇oğlu, Yasemin} }
APA Eli̇bol, E , Akdeveli̇oğlu, Y . (2020). The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body. Journal of Gazi University Health Sciences Institute , 2 (1) , 18-27 . Retrieved from https://dergipark.org.tr/tr/pub/guhes/issue/54114/701814
MLA Eli̇bol, E , Akdeveli̇oğlu, Y . "The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body". Journal of Gazi University Health Sciences Institute 2 (2020 ): 18-27 <https://dergipark.org.tr/tr/pub/guhes/issue/54114/701814>
Chicago Eli̇bol, E , Akdeveli̇oğlu, Y . "The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body". Journal of Gazi University Health Sciences Institute 2 (2020 ): 18-27
RIS TY - JOUR T1 - The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body AU - Emine Eli̇bol , Yasemin Akdeveli̇oğlu Y1 - 2020 PY - 2020 N1 - DO - T2 - Journal of Gazi University Health Sciences Institute JF - Journal JO - JOR SP - 18 EP - 27 VL - 2 IS - 1 SN - 2687-6353- M3 - UR - Y2 - 2020 ER -
EndNote %0 Gazi Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body %A Emine Eli̇bol , Yasemin Akdeveli̇oğlu %T The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body %D 2020 %J Journal of Gazi University Health Sciences Institute %P 2687-6353- %V 2 %N 1 %R %U
ISNAD Eli̇bol, Emine , Akdeveli̇oğlu, Yasemin . "The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body". Journal of Gazi University Health Sciences Institute 2 / 1 (Nisan 2020): 18-27 .
AMA Eli̇bol E , Akdeveli̇oğlu Y . The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body. GUHES. 2020; 2(1): 18-27.
Vancouver Eli̇bol E , Akdeveli̇oğlu Y . The Effects of Acyl and Desacyl Forms of The Ghrelin Hormone on The Body. Journal of Gazi University Health Sciences Institute. 2020; 2(1): 27-18.