BIOLOGICAL ACTIVITY STUDIES OF SOME SYNTHESIZED NOVEL FURAN AND PYRAN DERIVATIVES

Year 2017, Volume: 30 Issue: 4, 49 - 55, 11.12.2017

Esma Sari Hakan Aslan Şeyma Dadı Atilla Öktemer Elif Loğoğlu

Abstract

In this study, some
novel furan and pyran derivatives 1-[4-(1-hydroxyethyl)-2-methyl-5-phenyl-4,5
dihydrofuran-3-il]ethanone (1); 
1-(4-Hydroxymethyl-5,5-dimethyl-2-phenyl-4,5-dihydro-furan-3-il)ethanone
(2);  Ethyl 2-methyl-5-phenyl-5-styryl-4,5-dihydro-furan-3-carboxylate
(3);  Ethyl
4-hydroxymethyl-2,5,5-trimethyl-4,5-dihydro-furan-3-carboxylate (4);  Ethyl
4-(1-hydroxy-ethyl)-2-methyl-5-phenyl-4,5-dihydro-furan-3-carboxylate (5) Ethyl
5-hydroxy-2,6,6-trimethyl-5,6-dihydro-4H-pyran-3-carboxylate (6) were synthesized
as mentioned in our previous report [1].

The in vitro novel
furan and pyran derivatives were investigated for antibacterial activity
against gram-positive bacteria i.e. Bacillus licheniformis M30 , Bacillus
megaterium M22, Bacillus circulans M34, Bacillus subtilis B1
, Bacillus subtilis M33 , Bacillus cereus B9,  Staphylococcus aureus ATCC 653,  Micrococcus luteus M3 and gram-negative
i.e. Escherichia coli ATCC 25922 , and as a fungus  Pseudomonas
aeruginosa P7. The antibacterial  and antifungal activities were determined by
the disc diffusion method (DISC) and minimum inhibition concentration (MIC)
against the tested gram-positive and gram-negative bacteria and fungus. The
inhibition zones were compared with those of reference discs which were studied
in our previous work [2]. Reference discs used for control were as follows
ketoconazole, ampicillin, tetracycline, penicillin, chloramphenicol, and
gentamicin. From the results it could be said that some of the chemical
compound can be used as a raw medicine sources.  Their antibiogram tests showed better results than some known
antibiotics.

Keywords

Antibacterial Activity, Antifungal Activity, Furan, Pyran

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