Nanoparticle-Based Drug Delivery Systems and Targeting Strategies in Breast Cancer Therapy

Year 2025, Volume: 8 Issue: 1, 81 - 101, 30.04.2025

Ceren Çolak

https://doi.org/10.46373/hafebid.1652048

Abstract

Breast cancer continues to be a major contributor to cancer-related mortality globally, highliting the critical importance of developing more efficient and safer therapy strategies. Nanoparticle-based drug delivery systems offer a promising approach by enhancing drug accumulation in tumor tissues while minimizing systemic toxicity. This article explores the unique properties and advantages of various nanoparticles, including liposomal, polymer-, carbon- and mesoporous silica nanoparticles, in breast cancer therapy. Additionally, it delves into three key targeting mechanisms: passive targeting via the enhanced permeability and retention (EPR) effect, active targeting using ligands and antibodies, and stimuli-responsive drug delivery systems. Integrating nanotechnology into breast cancer therapy paves the way for more precise, efficient, and personalized therapy options, offering new hope for improved patient outcomes.

Keywords

Breast Cancer , Drug Delivery Systems , Nanoparticle

Meme Kanseri Tedavisinde Nanopartikül Tabanlı İlaç Taşıma Sistemleri ve Hedefleme Stratejileri

Abstract

Breast cancer continues to be a major contributor to cancer-related mortality globally,
highlighting the critical importance of developing more efficient and safer therapy
strategies. Nanoparticle-based drug delivery systems offer a promising approach by
enhancing drug accumulation in tumor tissues while minimizing systemic toxicity.
This article explores the unique properties and advantages of various nanoparticles,
including liposomal, polymer-, metal-, carbon- and mesoporous silica nanoparticles,
in breast cancer therapy. Additionally, it delves into three key targeting mechanisms:
passive targeting via the enhanced permeability and retention (EPR) effect, active
targeting using ligands and antibodies, and stimuli-responsive drug delivery systems.
Integrating nanotechnology into breast cancer therapy paves the way for more
precise, efficient, and personalized therapy options, offering new hope for improved
patient outcomes.
Keywords: Breast Cance

Keywords

Meme Kanseri , İlaç Dağıtım Sistemleri , Nanopartikül

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