Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı

Deniz Kanca Demirci; Nurdan Gül; İlhan Satman; Oguz Ozturk; Hülya Yılmaz Aydoğan

doi:10.46373/hafebid.880832

Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı

Abstract

Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) otozomal dominant kalıtım ile karakterize monogenik bir hastalıktır. Şimdiye kadar 14 farklı gende çok sayıda heterozigot mutasyonlar tanımlanmış olup bu mutasyonların dağılımı her ülkede farklıdır. Çalışmamızda yaygın MODY alt tipleri, MODY1-3, için literatür araştırması yaparak HNF4A, GCK ve HNF1A genlerindeki yanlış anlamlı mutasyonları özetledik. Ancak Asya populasyonlarında bilinen MODY genleri bu diyabetik bireylere tanı koymak için yeterli olmayıp çoğu MODYX olarak tanımlanmaktadır. Dahası, Avrupa ülkeleri ile kıyaslandığında Çin, Japonya, Kore ve Hindistan populasyonlarında MODY prevalansında çelişkiler mevcut olup hastalığın genetik alt yapısının daha iyi anlaşılması için daha fazla genetik çalışmaya ihtiyaç duyulmaktadır.

Keywords

References

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Details

Primary Language

Turkish

Subjects

-

Journal Section

Review

Authors

Deniz Kanca Demirci ^*
Türkiye

Nurdan Gül
Türkiye

İlhan Satman
0000-0001-8613-1797
Türkiye

Oguz Ozturk
Türkiye

Hülya Yılmaz Aydoğan
Türkiye

Publication Date

March 30, 2021

Submission Date

February 15, 2021

Acceptance Date

March 11, 2021

Published in Issue

Year 2021 Volume: 4 Number: 1

DOI

https://doi.org/10.46373/hafebid.880832

IZ

https://izlik.org/JA76SL43UH

Cite

RIS / Bibtex

APA

Kanca Demirci, D., Gül, N., Satman, İ., Ozturk, O., & Yılmaz Aydoğan, H. (2021). Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı. Haliç Üniversitesi Fen Bilimleri Dergisi, 4(1), 41-68. https://doi.org/10.46373/hafebid.880832

AMA

1.Kanca Demirci D, Gül N, Satman İ, Ozturk O, Yılmaz Aydoğan H. Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı. Natural Sciences - General. 2021;4(1):41-68. doi:10.46373/hafebid.880832

Chicago

Kanca Demirci, Deniz, Nurdan Gül, İlhan Satman, Oguz Ozturk, and Hülya Yılmaz Aydoğan. 2021. “Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK Ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı”. Haliç Üniversitesi Fen Bilimleri Dergisi 4 (1): 41-68. https://doi.org/10.46373/hafebid.880832.

EndNote

Kanca Demirci D, Gül N, Satman İ, Ozturk O, Yılmaz Aydoğan H (March 1, 2021) Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı. Haliç Üniversitesi Fen Bilimleri Dergisi 4 1 41–68.

IEEE

[1]D. Kanca Demirci, N. Gül, İ. Satman, O. Ozturk, and H. Yılmaz Aydoğan, “Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı”, Natural Sciences - General, vol. 4, no. 1, pp. 41–68, Mar. 2021, doi: 10.46373/hafebid.880832.

ISNAD

Kanca Demirci, Deniz - Gül, Nurdan - Satman, İlhan - Ozturk, Oguz - Yılmaz Aydoğan, Hülya. “Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK Ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı”. Haliç Üniversitesi Fen Bilimleri Dergisi 4/1 (March 1, 2021): 41-68. https://doi.org/10.46373/hafebid.880832.

JAMA

1.Kanca Demirci D, Gül N, Satman İ, Ozturk O, Yılmaz Aydoğan H. Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı. Natural Sciences - General. 2021;4:41–68.

MLA

Kanca Demirci, Deniz, et al. “Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK Ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı”. Haliç Üniversitesi Fen Bilimleri Dergisi, vol. 4, no. 1, Mar. 2021, pp. 41-68, doi:10.46373/hafebid.880832.

Vancouver

1.Deniz Kanca Demirci, Nurdan Gül, İlhan Satman, Oguz Ozturk, Hülya Yılmaz Aydoğan. Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı. Natural Sciences - General. 2021 Mar. 1;4(1):41-68. doi:10.46373/hafebid.880832

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https://doi.org/10.38053/acmj.1338092