Royal Jelly; Biochemical Properties, Activity and Medical Use
Yıl 2024,
Cilt: 65 Sayı: 2, 196 - 205, 31.12.2024
Ekin Varol
,
Ralitsa Balkanska
,
Banu Yücel
Öz
Royal jelly has a rich nutrient content and valued natural bee product which has been mainly used in traditional medicines to protects and strengthens the health. It is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. Because of its functional properties, royal jelly is very effective in accelerating the protection of health and healing process in many diseases. The high quality and scientific standardization of royal jelly is very important for using it in prevention of health and medical use in treatment disease in complimentary medicine. This review explains the effects of royal jelly on medical use for human health.
Kaynakça
- Abdelnour, S., El-Hack, M., Alagawany, M., Taha, A., Elnesr, S. et al. Useful impacts of royal jelly on reproductive sides, fertility rate and sperm traits of animals. Journal of animal physiology and animal nutrition, 2020.
- Ahmad, S., Campos, M., Fratini, F., Altaye, S., Li, J. New Insights into the Biological and Pharmaceutical Properties of Royal Jelly. International Journal of Molecular Sciences, 2020,21.
- Almeer, R., Kassab, R., Albasher, G., Alarifi, S., Alkahtani, S. et al. Royal jelly mitigates cadmium-induced neuronal damage in mouse cortex. Molecular Biology Reports, 2018, 46, 119-31.
- Asama, T., Matsuzaki, H., Fukushima, S., Tatefuji, T., Hashimoto, K. et al., Royal Jelly Supplementation Improves Menopausal Symptoms Such as Backache, Low Back Pain, and Anxiety in Postmenopausal Japanese Women. Evidence-based Complementary and Alternative Medicine. eCAM, 2018.
- Bagameri, L., Baci, G.M., Dezmirean, D.S. Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity. Pharmaceutics, 2022, 14(6): 1142.
- Bălan, A., Moga, M.A., Dima, L., Toma, S., Elena Neculau, A. et al. Royal jelly—A traditional and natural remedy for postmenopausal symptoms and aging-related pathologies. Molecules, 2020 vol. ED-25, pp. 3291.
- Balkanska, R., Kashamov, B. Composition and Physico-Chemical Properties of Lyophilized Royal Jelly. Bee Science, 2011, 11: 114-117.
- Botezan, S., Baci, G., Bagameri, L., Pașca, C., Dezmirean, D. Current Status of the Bioactive Properties of Royal Jelly: A Comprehensive Review with a Focus on Its Anticancer, Anti-Inflammatory, and Antioxidant Effects. Molecules, 2023 28.
- Bouamama, S., Merzouk, H., Latrech, H., Charif, N., Bouamama, A. Royal jelly alleviates the detrimental effects of aging on immune functions by enhancing the in vitro cellular proliferation, cytokines, and nitric oxide release in aged human PBMCS. J Food Biochem. 2021, 45: e13619.
- Chen, D., Liu, F., Wan, J., Lai, C., Shen, L. Effect of Major Royal Jelly Proteins on Spatial Memory in Aged Rats: Metabolomics Analysis in Urine. Journal of agricultural and food chemistry, 2017, 65 15, 3151-3159.
- Chi, X., Liu, Z., Wang, H., Wang, Y., Wei, W., Xu, B. Royal jelly enhanced the antioxidant activities and modulated the gut microbiota in healthy mice. Journal of food biochemistry, 2021, e13701.
- Fang, Y., Feng, M., Ma, C., Rueppell, O., Li, J. Major royal jelly proteins influence the neurobiological regulation of the division of labor among honeybee workers. International Journal of Biological Macromolecules, 2023, 225: 848-60.
- Fratini, F., Cilia, G., Mancini, S., Felicioli, A. Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiological research, 2016, 192:130-141.
- Fujisue, K., Yamamoto, E., Sueta, D., Arima, Y., Hirakawa, K., Tabata, N., Ishii, M., Ito, M., Yamanaga, K., Hanatani, S., Hoshiyama, T., Kanazawa, H., Takashio, S., Araki, S., Usuku, H. et al. A Randomized, Double-Blind Comparison Study of Royal Jelly to Augment Vascular Endothelial Function in Healthy Volunteers. Journal of atherosclerosis and thrombosis, 2022, 29(9), 1285–94.
- Gu, H., Song, I., Han, H., Lee, N., Cha, J., Son, Y., Kwon, J. Anti-inflammatory and immune-enhancing effects of enzyme-treated royal jelly. Applied Biological Chemistry. 2018, 61, 227-233.
- Guo, H., Saiga, A., Sato, M., Miyazawa, I., Shibata, M., Takahata, Y., & Morimatsu, F. Royal jelly supplementation improves lipoprotein metabolism in humans. Journal of nutritional science and vitaminology, 2007, 53(4): 345-8.
- Guo, J., Wang, Z., Chen, Y., Cao, J., Tian, W., Ma, B., Dong, Y. Active components and biological functions of royal jelly. Journal of Functional Foods, 2021.
- Guo, J., Ma, B., Wang, Z., Chen, Y., Tian, W., Dong, Y. Royal Jelly Protected against Dextran-Sulfate-Sodium-Induced Colitis by Improving the Colonic Mucosal Barrier and Gut Microbiota. Nutrients, 2022, 14.
- Han, S., Yeo, J., Cho, Y., Pak, S. Royal jelly reduces melanin synthesis through down-regulation of tyrosinase expression. The American journal of Chinese medicine, 2011, 39 6, 1253-60.
- Hryniewicka, M., Karpińska, A., Kijewska, M., Turkowicz, M., Karpińska, J. LC/MS/MS analysis of α-tocopherol and coenzyme Q10 content in lyophilized royal jelly, beebread and drone homogenate. Journal of mass spectrometry: JMS, 2016, (51)11: 1023-1029.
- Iegaki, N., Narita, Y., Hattori, N., Hirata, Y., Ichihara, K. Royal jelly reduces depression-like behavior through possible effects on adrenal steroidogenesis in a murine model of unpredictable chronic mild stress. Bioscience, Biotechnology, and Biochemistry, 2019,84:606-12.
- Kawano, Y., Makino, K., Jinnin, M., Sawamura, S., Shimada, S., Fukushima, S., Ihn, H. Royal jelly regulates the proliferation of human dermal microvascular endothelial cells through the down-regulation of a photoaging-related microRNA. Drug discoveries & therapeutics, 2019, 13 5, 268-73.
- Kazemi, V., Mojtahedzadeh, M., Siadat, S., Hadjiakhondí, A., Ameri, A. et al. Evaluation the Effect of Royal Jelly on the Growth of Two Members of Gut Microbiota; Bacteroides fragillis and Bacteroides thetaiotaomicron. Journal of Contemporary Medical Sciences, 2019.
- Khoob, M., Hosseini, S., Kazemi, S. In Vitro and In Vivo Antioxidant and Anticancer Potentials of Royal Jelly for Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats. Oxidative Medicine and Cellular Longevity, 2022.
- Kolaylı, S., Keskin, M. (2020). Chapter 7 - Natural bee products and their apitherapeutic applications. Studies in Natural Products Chemistry, Elsevier, 2020, 66: 175-196.
- Kunugi H., Ali, A.M. Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans. Int. J. Mol. Sci. 2019, 20: 4662.
- Li, J., Wang, T., Zhang, Z., Pan, Y. Proteomic analysis of royal jelly from three strains of western honeybees (Apis mellifera). Journal of Agricultural and Food Chemistry, 2007, 55: 8411-8422.
- Lin, Y., Shao, Q., Zhang, M., Lu, C., Fleming, J., Su, S. Royal jelly-derived proteins enhance proliferation and migration of human epidermal keratinocytes in an in vitro scratch wound model. BMC Complement. Altern. Med. 2019, 19, 1–16.
- Lin, Y., Zhang, M., Wang, L., Lin, T., Wang, G. et al. The in vitro and in vivo wound-healing effects of royal jelly derived from Apis mellifera L. during blossom seasons of Castanea mollissima Bl. and Brassica napus L. in South China exhibited distinct patterns. BMC Complementary Medicine and Therapies, 2020, 20.
- Maleki, V., Jafari-Vayghan, H., Saleh-Ghadimi, S., Adibian, M., Kheirouri, S., Alizadeh, M. Effects of Royal jelly on metabolic variables in diabetes mellitus: A systematic review. Complementary therapies in medicine, 2019, 43, 20-27.
- Mateescu, C. Apitherapy; New Approach for Honey and Hive Products, 6th Apimedica & 5th Apiquality Symposium Rome, Italy, 22-25th November, 2016.
- Maželienė, Ž., Aleksandravičienė, A., Pašvenskaitė, M., Viliušienė, I., Šakienė, D., Dailidaitė, Evelina. Antimicrobial activity of royal jelly, honey, and their mixture. Biologija, 2022, 68.
- Mishima, S., Suzuki, K., Isohama, Y., Kuratsu, N., Araki, Y. et al. Royal jelly has estrogenic effects in vitro and in vivo. Journal of ethnopharmacology, 2005, 101 (1-3): 215-20.
- Morita, H., Ikeda, T., Kajita, K., Fujioka, K., Mori, I. et al. Effect of royal jelly ingestion for six months on healthy volunteers. Nutrition Journal, 2012, 11, 77 - 77.
- Münstedt, K., Bargello, M., Hauenschild, A. Royal jelly reduces the serum glucose levels in healthy subjects. J Med Food. 2009; 12(5):1170-1172.
- Münstedt, K., Männle, H. Seasonal allergic rhinitis and the role of apitherapy. Allergologia et immunopathologia, 2020, 48(6), 582–88.
- Nazarzadeh, M., Jalili, C., Fathi, A., Ghanbari, A., Bakhtiari, M. Royal‐jelly‐based apitherapy can attenuate damages to male reproductive parameter following nicotine administration. Animal Models and Experimental Medicine, 2022, 5: 133 - 140.
- Okamoto, H., Ohkuma, A., Kawaguchi, M., Shigematsu, N., Okumura, N. Royal Jelly Increases Hematopoietic Stem Cells in Peripheral Blood: A Double-Blind, Placebo-Controlled, Randomized Trial in Healthy Subjects. Evidence-based complementary and alternative medicine : eCAM, 2023, 7665515.
- Okumura, N., Ito, T., Degawa, T., Moriyama, M., Moriyama, H. Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression. International Journal of Molecular Sciences, 2021, 22.
- Oršolić, N., Jembrek, M. Royal Jelly: Biological Action and Health Benefits. International Journal of Molecular Sciences, 2024, 25.
- Pourmoradian, S., Mahdavi, R., Mobasseri, M., Faramarzi, E., Mobasseri, M. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial. Chinese Journal of Integrative Medicine, 2014, 20:347-52.
- Ramanathan, A.N.K.G., Nair, A.J., Sugunan, V.S. A review on Royal Jelly proteins and peptides. Journal of Functional Foods, 2018, 44:255-264.
- Sabatini, A., Marcazzan, G., Caboni, M., Bogdanov, S., Almeida-Muradian, L. Quality and standardisation of Royal Jelly. Journal of ApiProduct and ApiMedical Science, 2009, (1) 1-6.
- Schmitzová, J., Klaudiny, J., Albert, Š. et al. A family of major royal jelly proteins of the honeybee Apis mellifera L. Cell. Mol. Life Sci., 1998, 54: 1020-30.
- Sesta, G. Determination of sugars in royal jelly by HPLC. Apidologie, 2006, 37, 84–90.
- Seyyedi, F., Rafiean-Kopaei, M., Miraj,S., Comparison of the Effects of Vaginal Royal Jelly and Vaginal Estrogen on Quality of Life, Sexual and Urinary Function in Postmenopausal Women. J Clin Diagn Res., 2016, 10(5):1-5.
- Shafiee, Z., Hanifi, N., Rashtchi, V. The effect of royal jelly on the level of consciousness in patients with traumatic brain injury: A double-blind randomized clinical trial. Nursing and Midwifery Studies, 2022, 11, 96 - 102.
- Sığ, A.K., Öz-Sığ, Ö., Güney, M. Royal jelly: a natural therapeutic? Ortadogu Tıp Derg., 2019, 11(3): 333-341.
- Silva, T., Paulo, M., Silva, J., Alves, A., Britto, L., Xavier, G., Sandoval, M. Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease. Heliyon, 2020, 6.
- Spanidi, E., Athanasopoulou, S., Liakopoulou, A., Chaidou, A., Hatziantoniou, S., Gardikis, K. Royal Jelly Components Encapsulation in a Controlled Release System—Skin Functionality, and Biochemical Activity for Skin Applications. Pharmaceuticals, 2020, 15.
- Strant, M., Yücel, B., Topal E., Puscasu A.M., Margaoan, R., Varadi A. Use of Royal Jelly as Functional Food in Human and Animal Health, J. Anim. Prod., 2019, 60 (2): 131-144.
- Sver, L., Orsolić, N., Tadić, Z., Njari, B., Valpotić, I., Basić, I. A royal jelly a new potential immunomodulator in rats and mice. Comp. Immun. Microbiol. Infect. Dis. 1996, 19:31–38.
- Taavoni, S., Barkhordari, F., Goushegir, A., Haghani, H. Effect of Royal Jelly on premenstrual syndrome among Iranian medical sciences students: a randomized, triple-blind, placebo-controlled study. Complementary therapies in medicine, 2014, 22 4, 601-6.
- Uthaibutra, V., Kaewkod, T., Prapawilai, P., Pandith, H., Tragoolpua, Y. Inhibition of Skin Pathogenic Bacteria, Antioxidant and Anti-Inflammatory Activity of Royal Jelly from Northern Thailand, Molecules, 2023, 28.
- Uversky, V., Albar, A., Khan, R., Redwan, E. Multifunctionality and intrinsic disorder of royal jelly proteome. Proteomics, 2021, 21.
- Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., Pérez-Alvarez, J. A. Functional properties of honey, propolis, and royal jelly. Journal of food science, 2008, 73(9), 117–124.
- Wang, S., Chen, C. Effects of royal jelly extracts on growth inhibition, differentiation human leukemic U937 cells and its immunomodulatory activity. Biocell, 2019, 43.
- Wang, W., Li, X., Li, D., Pan, F., Fang, X., Peng, W., Tian, W. Effects of Major Royal Jelly Proteins on the Immune Response and Gut Microbiota Composition in Cyclophosphamide-Treated Mice. Nutrients, 2023, 15, 974.
- Xue, X., Wu, L., Wang, K. Chemical Composition of Royal Jelly. In: Alvarez-Suarez, J. (eds) Bee Products - Chemical and Biological Properties. Springer, 2017 Cham.
- Yamaura, K., Tomono, A., Suwa, E., Ueno, K. Topical royal jelly alleviates symptoms of pruritus in a murine model of allergic contact dermatitis. Pharmacognosy Magazine, 2013, 9, 9-13.
- Yücel, B., Topal, E., Kösoğlu, M. Bee Products as Functional Food. Chapter 2. Super Food and Functional Food. (Ed: Waisundara, V. and Shiomi, N.) In Tech Publications, Rijeka, Croatia. 2017, ISBN: 978-953-51-2916-2.
- Zhang, S., Nie, H., Shao, Q., Hassanyar, A., Su, S. RNA-Seq analysis on effects of royal jelly on tumour growth in 4T1-bearing mice. Journal of Functional Foods, 2017, 36, 459-66.
Arı sütü; biyokimasal özellikleri, aktivitesi ve tıbbi kullanımı
Yıl 2024,
Cilt: 65 Sayı: 2, 196 - 205, 31.12.2024
Ekin Varol
,
Ralitsa Balkanska
,
Banu Yücel
Öz
Arı sütü, zengin besin içeriğine sahip ve sağlığı korumak ve güçlendirmek için geleneksel tıpta ağırlıklı olarak kullanılan değerli bir doğal arı ürünüdür. Hemşire arıların hipofaringeal ve mandibular bezlerinin sarımsı beyaz ve asidik bir salgısıdır ve ana arıların ilk üç günü ve tüm yaşamı boyunca genç işçi larvaları beslemek için kullanılır. İşlevsel özellikleri nedeniyle arı sütü, birçok hastalıkta sağlığın korunması ve iyileşme sürecinin hızlandırılmasında çok etkilidir. Arı sütünün yüksek kalitesi ve bilimsel standardizasyonu, sağlığın korunmasında ve tamamlayıcı tıpta hastalıkların tedavisinde kullanılabilmesi için çok önemlidir. Bu derlemede arı sütünün insan sağlığı için tıbbi kullanımdaki etkileri açıklanmaktadır.
Kaynakça
- Abdelnour, S., El-Hack, M., Alagawany, M., Taha, A., Elnesr, S. et al. Useful impacts of royal jelly on reproductive sides, fertility rate and sperm traits of animals. Journal of animal physiology and animal nutrition, 2020.
- Ahmad, S., Campos, M., Fratini, F., Altaye, S., Li, J. New Insights into the Biological and Pharmaceutical Properties of Royal Jelly. International Journal of Molecular Sciences, 2020,21.
- Almeer, R., Kassab, R., Albasher, G., Alarifi, S., Alkahtani, S. et al. Royal jelly mitigates cadmium-induced neuronal damage in mouse cortex. Molecular Biology Reports, 2018, 46, 119-31.
- Asama, T., Matsuzaki, H., Fukushima, S., Tatefuji, T., Hashimoto, K. et al., Royal Jelly Supplementation Improves Menopausal Symptoms Such as Backache, Low Back Pain, and Anxiety in Postmenopausal Japanese Women. Evidence-based Complementary and Alternative Medicine. eCAM, 2018.
- Bagameri, L., Baci, G.M., Dezmirean, D.S. Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity. Pharmaceutics, 2022, 14(6): 1142.
- Bălan, A., Moga, M.A., Dima, L., Toma, S., Elena Neculau, A. et al. Royal jelly—A traditional and natural remedy for postmenopausal symptoms and aging-related pathologies. Molecules, 2020 vol. ED-25, pp. 3291.
- Balkanska, R., Kashamov, B. Composition and Physico-Chemical Properties of Lyophilized Royal Jelly. Bee Science, 2011, 11: 114-117.
- Botezan, S., Baci, G., Bagameri, L., Pașca, C., Dezmirean, D. Current Status of the Bioactive Properties of Royal Jelly: A Comprehensive Review with a Focus on Its Anticancer, Anti-Inflammatory, and Antioxidant Effects. Molecules, 2023 28.
- Bouamama, S., Merzouk, H., Latrech, H., Charif, N., Bouamama, A. Royal jelly alleviates the detrimental effects of aging on immune functions by enhancing the in vitro cellular proliferation, cytokines, and nitric oxide release in aged human PBMCS. J Food Biochem. 2021, 45: e13619.
- Chen, D., Liu, F., Wan, J., Lai, C., Shen, L. Effect of Major Royal Jelly Proteins on Spatial Memory in Aged Rats: Metabolomics Analysis in Urine. Journal of agricultural and food chemistry, 2017, 65 15, 3151-3159.
- Chi, X., Liu, Z., Wang, H., Wang, Y., Wei, W., Xu, B. Royal jelly enhanced the antioxidant activities and modulated the gut microbiota in healthy mice. Journal of food biochemistry, 2021, e13701.
- Fang, Y., Feng, M., Ma, C., Rueppell, O., Li, J. Major royal jelly proteins influence the neurobiological regulation of the division of labor among honeybee workers. International Journal of Biological Macromolecules, 2023, 225: 848-60.
- Fratini, F., Cilia, G., Mancini, S., Felicioli, A. Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiological research, 2016, 192:130-141.
- Fujisue, K., Yamamoto, E., Sueta, D., Arima, Y., Hirakawa, K., Tabata, N., Ishii, M., Ito, M., Yamanaga, K., Hanatani, S., Hoshiyama, T., Kanazawa, H., Takashio, S., Araki, S., Usuku, H. et al. A Randomized, Double-Blind Comparison Study of Royal Jelly to Augment Vascular Endothelial Function in Healthy Volunteers. Journal of atherosclerosis and thrombosis, 2022, 29(9), 1285–94.
- Gu, H., Song, I., Han, H., Lee, N., Cha, J., Son, Y., Kwon, J. Anti-inflammatory and immune-enhancing effects of enzyme-treated royal jelly. Applied Biological Chemistry. 2018, 61, 227-233.
- Guo, H., Saiga, A., Sato, M., Miyazawa, I., Shibata, M., Takahata, Y., & Morimatsu, F. Royal jelly supplementation improves lipoprotein metabolism in humans. Journal of nutritional science and vitaminology, 2007, 53(4): 345-8.
- Guo, J., Wang, Z., Chen, Y., Cao, J., Tian, W., Ma, B., Dong, Y. Active components and biological functions of royal jelly. Journal of Functional Foods, 2021.
- Guo, J., Ma, B., Wang, Z., Chen, Y., Tian, W., Dong, Y. Royal Jelly Protected against Dextran-Sulfate-Sodium-Induced Colitis by Improving the Colonic Mucosal Barrier and Gut Microbiota. Nutrients, 2022, 14.
- Han, S., Yeo, J., Cho, Y., Pak, S. Royal jelly reduces melanin synthesis through down-regulation of tyrosinase expression. The American journal of Chinese medicine, 2011, 39 6, 1253-60.
- Hryniewicka, M., Karpińska, A., Kijewska, M., Turkowicz, M., Karpińska, J. LC/MS/MS analysis of α-tocopherol and coenzyme Q10 content in lyophilized royal jelly, beebread and drone homogenate. Journal of mass spectrometry: JMS, 2016, (51)11: 1023-1029.
- Iegaki, N., Narita, Y., Hattori, N., Hirata, Y., Ichihara, K. Royal jelly reduces depression-like behavior through possible effects on adrenal steroidogenesis in a murine model of unpredictable chronic mild stress. Bioscience, Biotechnology, and Biochemistry, 2019,84:606-12.
- Kawano, Y., Makino, K., Jinnin, M., Sawamura, S., Shimada, S., Fukushima, S., Ihn, H. Royal jelly regulates the proliferation of human dermal microvascular endothelial cells through the down-regulation of a photoaging-related microRNA. Drug discoveries & therapeutics, 2019, 13 5, 268-73.
- Kazemi, V., Mojtahedzadeh, M., Siadat, S., Hadjiakhondí, A., Ameri, A. et al. Evaluation the Effect of Royal Jelly on the Growth of Two Members of Gut Microbiota; Bacteroides fragillis and Bacteroides thetaiotaomicron. Journal of Contemporary Medical Sciences, 2019.
- Khoob, M., Hosseini, S., Kazemi, S. In Vitro and In Vivo Antioxidant and Anticancer Potentials of Royal Jelly for Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats. Oxidative Medicine and Cellular Longevity, 2022.
- Kolaylı, S., Keskin, M. (2020). Chapter 7 - Natural bee products and their apitherapeutic applications. Studies in Natural Products Chemistry, Elsevier, 2020, 66: 175-196.
- Kunugi H., Ali, A.M. Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans. Int. J. Mol. Sci. 2019, 20: 4662.
- Li, J., Wang, T., Zhang, Z., Pan, Y. Proteomic analysis of royal jelly from three strains of western honeybees (Apis mellifera). Journal of Agricultural and Food Chemistry, 2007, 55: 8411-8422.
- Lin, Y., Shao, Q., Zhang, M., Lu, C., Fleming, J., Su, S. Royal jelly-derived proteins enhance proliferation and migration of human epidermal keratinocytes in an in vitro scratch wound model. BMC Complement. Altern. Med. 2019, 19, 1–16.
- Lin, Y., Zhang, M., Wang, L., Lin, T., Wang, G. et al. The in vitro and in vivo wound-healing effects of royal jelly derived from Apis mellifera L. during blossom seasons of Castanea mollissima Bl. and Brassica napus L. in South China exhibited distinct patterns. BMC Complementary Medicine and Therapies, 2020, 20.
- Maleki, V., Jafari-Vayghan, H., Saleh-Ghadimi, S., Adibian, M., Kheirouri, S., Alizadeh, M. Effects of Royal jelly on metabolic variables in diabetes mellitus: A systematic review. Complementary therapies in medicine, 2019, 43, 20-27.
- Mateescu, C. Apitherapy; New Approach for Honey and Hive Products, 6th Apimedica & 5th Apiquality Symposium Rome, Italy, 22-25th November, 2016.
- Maželienė, Ž., Aleksandravičienė, A., Pašvenskaitė, M., Viliušienė, I., Šakienė, D., Dailidaitė, Evelina. Antimicrobial activity of royal jelly, honey, and their mixture. Biologija, 2022, 68.
- Mishima, S., Suzuki, K., Isohama, Y., Kuratsu, N., Araki, Y. et al. Royal jelly has estrogenic effects in vitro and in vivo. Journal of ethnopharmacology, 2005, 101 (1-3): 215-20.
- Morita, H., Ikeda, T., Kajita, K., Fujioka, K., Mori, I. et al. Effect of royal jelly ingestion for six months on healthy volunteers. Nutrition Journal, 2012, 11, 77 - 77.
- Münstedt, K., Bargello, M., Hauenschild, A. Royal jelly reduces the serum glucose levels in healthy subjects. J Med Food. 2009; 12(5):1170-1172.
- Münstedt, K., Männle, H. Seasonal allergic rhinitis and the role of apitherapy. Allergologia et immunopathologia, 2020, 48(6), 582–88.
- Nazarzadeh, M., Jalili, C., Fathi, A., Ghanbari, A., Bakhtiari, M. Royal‐jelly‐based apitherapy can attenuate damages to male reproductive parameter following nicotine administration. Animal Models and Experimental Medicine, 2022, 5: 133 - 140.
- Okamoto, H., Ohkuma, A., Kawaguchi, M., Shigematsu, N., Okumura, N. Royal Jelly Increases Hematopoietic Stem Cells in Peripheral Blood: A Double-Blind, Placebo-Controlled, Randomized Trial in Healthy Subjects. Evidence-based complementary and alternative medicine : eCAM, 2023, 7665515.
- Okumura, N., Ito, T., Degawa, T., Moriyama, M., Moriyama, H. Royal Jelly Protects against Epidermal Stress through Upregulation of the NQO1 Expression. International Journal of Molecular Sciences, 2021, 22.
- Oršolić, N., Jembrek, M. Royal Jelly: Biological Action and Health Benefits. International Journal of Molecular Sciences, 2024, 25.
- Pourmoradian, S., Mahdavi, R., Mobasseri, M., Faramarzi, E., Mobasseri, M. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial. Chinese Journal of Integrative Medicine, 2014, 20:347-52.
- Ramanathan, A.N.K.G., Nair, A.J., Sugunan, V.S. A review on Royal Jelly proteins and peptides. Journal of Functional Foods, 2018, 44:255-264.
- Sabatini, A., Marcazzan, G., Caboni, M., Bogdanov, S., Almeida-Muradian, L. Quality and standardisation of Royal Jelly. Journal of ApiProduct and ApiMedical Science, 2009, (1) 1-6.
- Schmitzová, J., Klaudiny, J., Albert, Š. et al. A family of major royal jelly proteins of the honeybee Apis mellifera L. Cell. Mol. Life Sci., 1998, 54: 1020-30.
- Sesta, G. Determination of sugars in royal jelly by HPLC. Apidologie, 2006, 37, 84–90.
- Seyyedi, F., Rafiean-Kopaei, M., Miraj,S., Comparison of the Effects of Vaginal Royal Jelly and Vaginal Estrogen on Quality of Life, Sexual and Urinary Function in Postmenopausal Women. J Clin Diagn Res., 2016, 10(5):1-5.
- Shafiee, Z., Hanifi, N., Rashtchi, V. The effect of royal jelly on the level of consciousness in patients with traumatic brain injury: A double-blind randomized clinical trial. Nursing and Midwifery Studies, 2022, 11, 96 - 102.
- Sığ, A.K., Öz-Sığ, Ö., Güney, M. Royal jelly: a natural therapeutic? Ortadogu Tıp Derg., 2019, 11(3): 333-341.
- Silva, T., Paulo, M., Silva, J., Alves, A., Britto, L., Xavier, G., Sandoval, M. Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease. Heliyon, 2020, 6.
- Spanidi, E., Athanasopoulou, S., Liakopoulou, A., Chaidou, A., Hatziantoniou, S., Gardikis, K. Royal Jelly Components Encapsulation in a Controlled Release System—Skin Functionality, and Biochemical Activity for Skin Applications. Pharmaceuticals, 2020, 15.
- Strant, M., Yücel, B., Topal E., Puscasu A.M., Margaoan, R., Varadi A. Use of Royal Jelly as Functional Food in Human and Animal Health, J. Anim. Prod., 2019, 60 (2): 131-144.
- Sver, L., Orsolić, N., Tadić, Z., Njari, B., Valpotić, I., Basić, I. A royal jelly a new potential immunomodulator in rats and mice. Comp. Immun. Microbiol. Infect. Dis. 1996, 19:31–38.
- Taavoni, S., Barkhordari, F., Goushegir, A., Haghani, H. Effect of Royal Jelly on premenstrual syndrome among Iranian medical sciences students: a randomized, triple-blind, placebo-controlled study. Complementary therapies in medicine, 2014, 22 4, 601-6.
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