hitit medical journal Hitit Medical Journal 2687-4717 Hitit Üniversitesi 10.52827/hititmedj.1320606 Haematology Hematoloji Brentuximab Vedotin Monotherapy in Relapsed/Refractory T Cell Lymphoma Setting-Real Life Data Relaps / Refrakter T Hücreli Lenfomada Brentuximab Vedotin Monoterapisi- Gerçek Yaşam Verisi https://orcid.org/0000-0001-5073-1790 Darcın Tahir SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0003-1855-774X Serın Istemi AĞRI EĞİTİM VE ARAŞTIRMAM HASTANESİ https://orcid.org/0000-0002-5600-3169 Ugur Mehmet Can SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR BOZYAKA SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI, HEMATOLOJİ BİLİM DALI https://orcid.org/0000-0002-4636-3590 Ekinci Omer Hematology, University of Health Sciences, Gazi Yasargil Training and Research Hospital https://orcid.org/0000-0003-1353-2367 Yönal Hindilerden İpek Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Istanbul, Turkey https://orcid.org/0000-0002-6961-8971 Akpınar Seval TEKIRDAG NAMIK KEMAL UNIVERSITY, SCHOOL OF MEDICINE https://orcid.org/0000-0003-1814-5972 Hacıbekiroglu Tuba Hematology, Sakarya University https://orcid.org/0000-0003-1277-5105 Demircioğlu Sinan Hematology, Necmettin Erbakan University, Meram Faculty of Medicine https://orcid.org/0000-0003-2836-6162 Gulturk Emine Hematology, University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital https://orcid.org/0000-0003-4025-741X Albayrak Murat ETLİK CITY HOSPITAL, DEPARTMENT OF HEMATOLOGY https://orcid.org/0000-0001-9350-1485 Aydoğdu İsmet Hematology, Celal Bayar University, Department of Internal Medicine https://orcid.org/0000-0002-5994-2735 Dal Mehmet Sinan SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ https://orcid.org/0000-0001-7237-2637 Doğu Mehmet Hilmi Hematology, Istinye University, Liv Hospital Ulus https://orcid.org/0000-0002-8074-7301 Namdaroğlu Sinem DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI https://orcid.org/0000-0003-0207-3505 Dogan Ali Internal Medicine, Yuzuncu Yil University, School of Medicine https://orcid.org/0000-0002-2555-5024 Nalçacı Meliha ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, HEMATOLOGY https://orcid.org/0000-0001-5729-0043 Turgut Burhan NAMIK KEMAL UNIVERSITY, SCHOOL OF MEDICINE https://orcid.org/0000-0003-4304-9245 Başcı Semih SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ https://orcid.org/0000-0001-6872-3780 Altuntaş Fevzi SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ 06 30 2024 6 2 186 192 11 20 2023 02 23 2024 Copyright © 2019, Hitit Medical Journal 2019 Hitit Medical Journal

Objective: We present data of patients with relapsed/ refractory T cell lymphomas treated with brentuximab vedotin (BV) in real-world practice. Material and Method: This study is an observational, multi-center, retrospective study. The data of patients (n=17) treated with BV alone from January 2014 until July 2020 in thirteen centers from Turkey were collected. Results: Bv was given as salvage chemotherapy to 17 patients with median age of 53. Nine (52.9%) patients had diagnosis of peripheral T cell lymphoma, not otherwise specified; 8 (47.1%) patients had anaplastic large T cell lymphoma. The median follow-up of the cohort was 20 months. Nine (52.9%) patients had complete response, 5 (29.5%) had partial response, 3 (17.6%) had progressive disease. The safety results aligned with the established profile of BV, included 2 pneumonia and 1 thrombocytopenia with grade 4. The median progression free survival of the cohort was 10 months. BV cycle and response to BV therapy were found to have an effect on the univariate analysis. Conclusion: In patients with relapsed/ refractory T cell lymphomas, BV seems to have convincing antitumor activity with favorable safety profile.

Amaç: Brentuksimab vedotin (BV) ile tedavi edilen Relaps /Refrakter (R/R) THL’li hastaların gerçek yaşam verilerini sunmayı amaçladık. Gereç ve Yöntem: Bu çalışma gözlemsel, çok merkezli, retrospektif bir çalışmadır. Ocak 2014’ten Temmuz 2020’ye kadar Türkiye’deki on üç merkezde yalnızca BV ile tedavi edilen tüm hastaların (n=17) verileri toplandı. Bulgular: Ortanca yaşı 53 olan 17 hastaya kurtarma kemoterapisi olarak BV verildi. Dokuz (%52,9) hastaya periferik T hücreli lenfoma, diğer türlü sınıflandırılamayan tanısı konurken, 8 (%47,1) hastaya anaplastik büyük T hücreli lenfoma tanısı konuldu. Kohortun ortanca takip süresi 20 aydı. Dokuz (%52,9) hastada tam yanıt, 5 (%29,5) hastada kısmi yanıt, 3 (%17,6) hastada ilerleyici hastalık görüldü. Güvenlik verileri BV bilinen profiliyle tutarlıydı, 2 pnömoni ve 4. dereceli 1 trombositopeniyi içeriyordu. Grubun medyan progresyonsuz sağkalımı 10 aydı. Siklus sayısının BV tedavisine yanıtın üzerinde etkili olduğu değişkenli analiz ile bulundu. Sonuç: R/R THL’leri olan hastalarda BV olumlu güvenlik profili ile tatmin edici antitümör aktivitesine sahip olduğu görülmektedir.

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