hitit medical journal Hitit Medical Journal 2687-4717 Hitit Üniversitesi 10.52827/hititmedj.1683368 Gynecologic Oncology Surgery Jinekolojik Onkoloji Cerrahisi Yetı̇şkı̇nlerde Ender Görülen Servı̇kal Rabdomı̇yosarkom Vakası A Rare Case of Cervical Rhabdomyosarcoma in Adults https://orcid.org/0000-0002-4070-7583 Akdemir Celal Department of Gynecologic Oncology, İzmir City Hospital https://orcid.org/0009-0007-3713-2700 Yıldız Halil İbrahim Department of Medical Oncology, University of Health Sciences Tepecik Training and Research Hospital https://orcid.org/0000-0002-2821-3273 Balcı Mücahit Furkan Department of Gynecology and Obstetrics, İzmir City Hospital https://orcid.org/0000-0002-0319-3560 Erdoğan Özgür Department of Gynecologic Oncology, İzmir City Hospital https://orcid.org/0000-0002-2202-2732 Ayaz Duygu Department of Pathology, University of Health Sciences Tepecik Training and Research Hospital https://orcid.org/0000-0001-8767-4275 Kelten Talu Esra Canan Department of Pathology, University of Health Sciences Tepecik Training and Research Hospital https://orcid.org/0000-0002-8494-4302 Sancı Muzaffer Department of Gynecologic Oncology, İzmir City Hospital 10 13 2025 7 3 476 481 04 24 2025 07 05 2025 Copyright © 2019, Hitit Medical Journal 2019 Hitit Medical Journal

Servikal embriyonel rabdomiyosarkom, kadın genital sistemindeki tüm servikal neoplazmların %1’inden azını oluşturan nadir görülen mezenkimal kaynaklı solid bir tümördür. Bu tümörün tedavisine yönelik standartlaştırılmış bir protokol bulunmamaktadır ve mevcut literatür büyük ölçüde olgu sunumları ve olgu serilerinden oluşmaktadır. Literatürde tanımlanan tedavi seçenekleri, fertilite koruyucu konservatif yaklaşımlardan, kemoterapi ve radyoterapi ile kombine edilen radikal cerrahiye kadar geniş bir yelpazeye yayılmaktadır. Cerrahi, kemoterapi ve radyoterapiyi içeren kombine tedavi yaklaşımının hastalığın seyrinde daha iyi sonuçlar sağladığı düşünülmektedir.Bu yazıda, servikste polipoid bir kitle ile başvuran 45 yaşında kadın hastada görülen bir servikal embriyonel rabdomiyosarkom olgusunu sunmaktayız. Yapılan histopatolojik ve immünohistokimyasal incelemeler, servikste lokalize olan kitlenin servikal kökenli olduğunu ve embriyonel rabdomiyosarkom ile uyumlu olduğunu doğrulamıştır. Hastaya total abdominal histerektomi uygulanmasının ardından adjuvan kemoradyoterapi kombinasyon tedavisi önerilmiş, tedavi ardından hasta 23 aydır hastalıksız izlenimine devam etmektedir.

Cervical embryonal rhabdomyosarcoma is a rare mesenchymal solid tumor that accounts for less than 1% of all cervical neoplasms in the female genital system. There is no standardized protocol for the treatment of cervical embryonal rhabdomyosarcoma, and the literature primarily consists of case reports and series. Treatment options described in the literature range from conservative, fertility-preserving approaches to radical surgery in combination with chemotherapy and radiotherapy. A combined approach involving surgery, chemotherapy, and radiotherapy is believed to yield better outcomes for the disease. In this article, we present a case of cervical embryonal rhabdomyosarcoma in a 45-year-old female patient presenting with a polypoid cervical mass. Histopathological and immunohistochemical examination confirmed that the localized mass in the cervix was of cervical origin and consistent with embryonal rhabdomyosarcoma. Following total abdominal hysterectomy, the patient was administered a combination treatment of adjuvant chemoradiotherapy, and she has remained disease-free for a period of 23 months.

 Cervical Cancer Rhabdomyosarcoma Mesenchymal Tumor Serviks Kanseri Rabdomyosarkom Mezenkimal Tümör Ibrahim U, Saqib A, Mohammad F, et al. Embryonal rhabdomyosarcoma of the cervix: a rare disease at an uncommon age. Cureus 2017;9(11):e1864. Sultan I, Qaddoumi I, Yaser S, Rodriguez-Galindo C, Ferrari A. Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: an analysis of 2,600 patients. J Clin Oncol 2009;27(20):3391–3397. Fletcher CDM, Bridge J, Hogendoorn PCW, Mertens F. WHO Classification of Tumours of Soft Tissue and Bone. Lyon: IARC Press; 2013. Behtash N, Mousavi A, Tehranian A, Khanafshar N, Hanjani P. Embryonal rhabdomyosarcoma of the uterine cervix: case report and review of the literature. Gynecol Oncol 2003;91(2):452–455. Liu YT, Wang CW, Hong RL, Kuo SH. Prognostic factors and treatment outcomes of adult patients with rhabdomyosarcoma after multimodality treatment. Anticancer Res 2019;39(3):1355–1364. Sardinha MGP, Ramajo FM, Ponce CC, et al. Uterine cavity embryonal rhabdomyosarcoma. Autops Case Rep 2019;9(3):e2019103. Buruiana FE, Gupta B, Singh K. Rhabdomyosarcoma of the cervix in teenagers: is fertility preservation a feasible option? Gynecol Oncol Rep 2020;34:100677. Hermoza AD, de Macêdo Matsushita G, dos Santos MH, Schmidt RL, dos Reis R, da Cunha Andrade CEM. Botryoid embryonal rhabdomyosarcoma of the cervix: a case report. Int J Surg Case Rep 2023;102:107858. Mousavi A, Akhavan S. Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters. J Gynecol Oncol 2010;21(4):273–275. Raney RB, Maurer HM, Anderson JR, et al. The Intergroup Rhabdomyosarcoma Study Group (IRSG): major lessons from the IRS-I through IRS-IV studies as background for the current IRS-V treatment protocols. Sarcoma 2001;5(1):9–15. Elsebaie MA, Elsayed Z. Is fertility-preservation safe for adult non-metastatic gynecologic rhabdomyosarcoma patients? Systematic review and pooled survival analysis of 137 patients. Arch Gynecol Obstet 2018;297(3):559–572. Li C, Yang S, Hua K. Nomogram predicting parametrial involvement based on the radical hysterectomy specimens in the early-stage cervical cancer. Front Surg 2021;8:489.