Toplum Kaynaklı Üriner Enfeksiyon Etkeni Escherichia coli Suşlarında Antibiyotik Direnci

Yıl 2021, Cilt: 3 Sayı: 2, 1 - 5, 30.06.2021

Recep Alanlı , Bülent Ahmet Beşirbellioğlu , Gültekin Çelik

https://doi.org/10.52827/hititmedj.888932

Cited By: 2

Öz

Amaç: Antibiyotik direnci önemli bir sağlık problemidir ve sağlık sistemi üzerine yaptığı olumsuz etkiler gün geçtikçe artmaktadır. Bu çalışmada; toplum kaynaklı üriner sistem enfeksiyonu etkeni Escherichia coli suşlarının antibiyotiklere duyarlılık oranları incelendi.

Gereç ve Yöntem: Temmuz 2019 ile Haziran 2020 arasında; toplum kaynaklı üriner sistem enfeksiyonu etkeni olarak Escherichia coli üremesi saptanan 494 hastanın antibiyogram sonuçları ve demografik özellikleri retrospektif olarak değerlendirildi.

Bulgular: Antibiyotiklerin Escherichia coli'ye gösterdikleri direnç oranları, en az ve en çok olanları sırasıyla; amikasin (%0,4), tigesiklin (%2), imipenem (%2), meropenem (%2), sefiksim (%32), seftriakson (%29) ve trimetoprim-sülfametaksazol (%28) olarak saptandı.

Sonuç: Toplumdan edinilmiş üriner sistem enfeksiyonunda ampirik olarak; oral fosfomisin veya nitrofurantoin ya da günde tek doz intramusküler amikasin kullanılmasının akılcı olacağı, öte yandan; sefiksim, trimetoprim-sülfametaksazol, siprofloksasin ve sefuroksim kullanılırken, yüksek antibiyotik direnci nedeniyle dikkatli olunması gerektiği düşünülmektedir.

Anahtar Kelimeler

Escherichia coli,, Antibiyotik Direnci, Üriner Enfeksiyon

Destekleyen Kurum

Yok

Proje Numarası

Yok

Antimicrobial Resistance of Escherichia coli Strains in Community Acquired Urinary Tract Infections

Öz

Introduction: Antibiotic resistance is one of the most important health issues and its negative effect on global health is increasing everyday. In this reported study, antibiotic sensitivity of Escherichia coli strains that cause community acquired urinary tract infections were inspected.

Method: Between July 2019 and June 2020, 494 patients in which Escherichia coli was isolated in cultures as community acquired urinary tract infection etiology were inspected. Antibiogram and demographic data of patients were evaluated retrospectively.

Results: Resistance of Escherichia coli for antibiotics from least to most frequent were found to be; amikacin (0.4%), imipenem (2%), meropenem (2%), fosfomycine (4%), nitrofurantoin (4%), ceftazidim (9%), amoxicillin/clavulonic acid (13%), ciprofloxacin (22%), trimethoprim-sulfamethoxazole (%28), ceftriaxsone (29%) and cefixime (32%).

Conclusion: In community acquired urinary tract infections, ampiric fosfomycine or nitrofurantoin oral intake or intramuscular amikacin administration will be wisely. On the other hand cefixime, trimethoprim-sulfamethoxazole, ciprofloxacin and cefuroksim usage must be reevaluated because of more frequent antibiotic resistance.

Anahtar Kelimeler

Escherichia coli,, Antibiotic Resistance, Urinary Tract Infection

Proje Numarası

Yok

Kaynakça

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