Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts

Enes Evren; Nevin Gürbüz; İsmail Özdemir

Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts

Abstract

Benzimidazole derivatives are prominent heterocyclic compounds, noted for their broad spectrum of biological activities and diverse application potential. In this study, novel benzimidazolium salts were synthesized via the reaction of various aryl halides with benzimidazole cores. Environmentally friendly solvents and high-purity, commercially available aryl groups were employed to ensure high yield and purity during the synthesis. The method presented herein offers a reliable, efficient, and scalable approach for the synthesis of benzimidazolium salts and contributes to their potential applications in pharmaceuticals, catalysis, and materials science. The structural characterization of the synthesized compounds was carried out using Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (¹H-NMR), and carbon nuclear magnetic resonance (¹³C-NMR) spectroscopy. The spectral data confirmed salt formation through characteristic shifts in N–H and C–N stretching frequencies, as well as downfield shifts observed in the proton signals of the benzimidazole ring. Compared to their salt precursors, the synthesized benzimidazolium salts exhibited significantly higher water solubility, indicating improved bioavailability potential for pharmaceutical applications.

Keywords

References

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Details

Primary Language

English

Subjects

Organometallic Chemistry

Journal Section

Research Article

Authors

Enes Evren ^*
Türkiye

Nevin Gürbüz
Türkiye

İsmail Özdemir
Türkiye

Publication Date

January 31, 2026

Submission Date

August 25, 2025

Acceptance Date

October 24, 2025

Published in Issue

Year 2026 Volume: 3 Number: 1

IZ

https://izlik.org/JA95YA95DH

Cite

RIS / Bibtex

APA

Evren, E., Gürbüz, N., & Özdemir, İ. (2026). Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts. Hitit Journal Of Science, 3(1). https://izlik.org/JA95YA95DH

AMA

1.Evren E, Gürbüz N, Özdemir İ. Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts. HJS. 2026;3(1). https://izlik.org/JA95YA95DH

Chicago

Evren, Enes, Nevin Gürbüz, and İsmail Özdemir. 2026. “Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts”. Hitit Journal Of Science 3 (1). https://izlik.org/JA95YA95DH.

EndNote

Evren E, Gürbüz N, Özdemir İ (January 1, 2026) Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts. Hitit Journal Of Science 3 1

IEEE

[1]E. Evren, N. Gürbüz, and İ. Özdemir, “Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts”, HJS, vol. 3, no. 1, Jan. 2026, [Online]. Available: https://izlik.org/JA95YA95DH

ISNAD

Evren, Enes - Gürbüz, Nevin - Özdemir, İsmail. “Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts”. Hitit Journal Of Science 3/1 (January 1, 2026). https://izlik.org/JA95YA95DH.

JAMA

1.Evren E, Gürbüz N, Özdemir İ. Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts. HJS. 2026;3. Available at https://izlik.org/JA95YA95DH.

MLA

Evren, Enes, et al. “Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts”. Hitit Journal Of Science, vol. 3, no. 1, Jan. 2026, https://izlik.org/JA95YA95DH.

Vancouver

1.Enes Evren, Nevin Gürbüz, İsmail Özdemir. Synthesis and Characterization of 1,3-Disubstituted Benzimidazolium Salts. HJS [Internet]. 2026 Jan. 1;3(1). Available from: https://izlik.org/JA95YA95DH