Simple Sensor Application: Determination of Electrochemical Properties of Carvedilol in CPE Based on Zinc Oxide Nanoparticles and Development of the Method for its Determination in Pharmaceutical Samples

Abstract

In the study, the electrochemical characteristics of carvedilol were determined by cyclic voltammetry and square wave voltammetry on carbon paste electrode with zinc oxide nanoparticles at pH 8.0 in Britton Robinson buffer. The adsorption characteristics of the molecule on the modified electrode and the electron number accompanying the electrode reaction were calculated. In addition, a new square wave anodic adsorptive stripping voltammetry process was suggested for the determination of carvedilol drug samples. The linear concentration range and detection limit of the process were found to be 0.07 µM–2.61 µM and 0.09 µM, respectively. Recovery studies of CAR in the pharmaceutical sample were performed to check the accuracy of the developed process. With the developed process, results with high reliability, reproduceability, accuracy and precision were obtained for the determination of CAR in pharmaceutical samples.

Keywords

• carbon paste elecreode
• carvedilol
• tablet
• stripping voltammetry
• zinc oxide nanoparticles

References

1. Kamal RE, Menze E, Albohy Amgad, Ahmed HI, Azab SS. Neuroprotective repositioning and anti-tau effect of carvedilol on rotenone-induced neurotoxicity in rats: Insights from an insilico and in vivo anti-Parkinson’s disease study. European Journal of Pharmacology 932 (2022) 175204.
2. Cardoso SG, Leggli CVS, Pomblum SCG. Spectrophotometric determination of carvedilol in pharmaceutical formulations through charge-transfer and ion-pair complexation reactions. Die Pharmazie - An International Journal of Pharmaceutical Sciences 62 (2007) 34-37.
3. Shetty DN, Narayana B. Simple Methods for the Spectrophotometric determination of carvedilol. ISRN Spectroscopy (2012) 373215.
4. Nayabaniya A, Seetharaman R, Lakshmi KS. Spectrophotometric determination of carvedilol in bulk drug and its formulation by multivariate calibration technique. Research Journal of Pharmacy and Technology 13 (2020) 915-922.
5. Myung SW, Hojo C. Gas chromatograph-mass spectrometric method for the determination of carvedilol and its metabolites in human urine. Journal of Chromatography B 822 (2005) 70-77.
6. Yılmaz B, Arslan Ş. Determination of carvedilol in human plasma by gas chromatography-mass spectrometry method. Journal of Chromatographic Science 49 (2011) 35-39.
7. Hamidi S, Soltani S, Jouyban A. A dispersive liquid–liquid microextraction and chiral separation of carvedilol in human plasma using capillary electrophoresis. Bioanalysis 7 (2015) 1107–1117.
8. Clohs L, McErlane KM. Development of a capillary electrophoresis assay for the determination of carvedilol enantiomers in serum using cyclodextrins. Journal of Pharmaceutical and Biomedical Analysis 24 (2001) 545 – 554.

9. Gannu R, Yamsani VV, Rao YM. New RP‐HPLC method with UV‐detection for the determination of carvedilol in human serum. Journal of Liquid Chromatography and Related Technologies 30 (2007) 1677-1685.
10. Hokama N, Hobara N, Kameya H, Ohshiro S, Sakanashi M. Rapid and simple micro-determination of carvedilol in rat plasma by high-performance liquid chromatography. Journal of Chromatography B 732 (1999) 233–238.
11. Rathod R, Prasad LPC, Rani S, Nivsarkar M, Padh H. Estimation of carvedilol in human plasma by using HPLC-fluorescence detector and its application to pharmacokinetic study. Journal of Chromatography B 857 (2007) 219–223.
12. Radi A, Elmogy T. Differential pulse voltammetric determination of carvedilol in tablets dosage form using glassy carbon electrode. II Farmaco 60 (2005) 43–46.
13. Rofouei MK, Khoshsafara H, Kalbasia RJ, Bagheri H. A sensitive electrochemical sensor for the determination of carvedilol based on modified glassy carbon electrode with an ordered mesoporous carbon. Royal Chemical Society, 6 (2016), 13160-13167.
14. Yılmaz B, Kaban S. Determination of carvedilol in pharmaceutical preparations by square wave and differential pulse voltammetry methods. Latin American Journal of Pharmacy 33 (2014) 595-600.
15. Shadjou N, Hasanzadeh M, Saghatforoush L, Mehdizadeh R, Jouyban A. Electrochemical behavior of atenolol, carvedilol and propranolol on copper oxide nanoparticles. Electrochimica Acta 58 (2011) 336–347.
16. Tajik S, Bertolami H, Nejad FG, Safaei, M, Zhang K. Developments and applications of nanomaterial-based carbon paste electrodes. Royal Society of Chemistry 10 (2020) 21561-21581.
17. Shashanka R, Chaira D, Kumara Swamy BE. Electrocatalytic response of duplex and yittria dispersed duplex stainless steel modified carbon paste electrode in detecting folic acid using cyclic voltammetry. International Journal of Electrochemical Science 10 (2015) 5586-5598.
18. Mahale RS, Shashanka R Vasanth S Vinaykumar R. Voltammetric determination of various food azo dyes using different modified carbon paste electrodes. Biointerface Research in Applied Chemistry 12 (2022) 4557-4566.
19. Erden PE, Zeybek B, Pekyardimcı Ş, Kılıç E. Amperometric carbon paste enzyme electrodes with Fe3O4 nanoparticles and 1, 4-Benzoquinone for glucose determination. Artificial Cells Nanomedicine, and Biotechnology 41 (2013) 165-171.
20. Çölkesen B, Öztürk F, Erden PE. Electroanalytical characterization of montelukast sodium and its voltammetric determination in pharmaceutical dosage form and biological fluids. Journal of the Brazilian Chemical Society 27 (2016) 849-856.
21. Amro AN, Emran K, Alanazi H. Voltammetric determination of itopride using carbon paste electrode modified with Gd doped TiO2 nanotubes. Turkish Journal of Chemistry 44 (2020) 1122-1133.
22. Shashanka R, Jayaprakash GK, Prakashaiah BG, Kumar M, Kumara Swamy BE. Electrocatalytic determination of ascorbic acid using a green synthesised magnetite nanoflake modified carbon paste electrode by cyclic voltammetric method. Materials Research Innovations 26 (2022) 229-239.
23. Ho MY, Khiew PS, Isa D, Tan TK, Chiu WS, Chia CH. A review of metal oxide composite electrode materials for electrochemical capacitors. Nano 9 (2014) 1430002.
24. Shashanka R, Kumara Swamy BE. Simultaneous electro generation and electrodeposition of copper oxide nanoparticles on glassy carbon electrode and its sensor application. SN Applied Sciences 2 (2020) 956.
25. Jiang J, Li Y, Liu J, Huang X, Yuan C, Lou XW. Recent advances in metal oxide‐based electrode architecture design for electrochemical energy storage. Advanced Materials 24 (2012) 5166-5180.
26. Cinková K, Kianičkova K, Stanković DM, Vojs M, Marton M, Svorc L. The doping level of boron-doped diamond electrodes affects the voltammetric sensing of uric acid. Analytical Methods 10 (2018) 991-996.
27. Nicholson RS, Shain I. Theory of stationary electrode polarography. Single scan and cyclic methods applied to reversible, irreversible, and kinetic systems. Analytical Chemistry 36 (1964) 706-723.
28. Coelho, MKL, Giarola JdeF, Maria da Silva AT, Tarley CRT, Borges KB, César Pereira A. Development and application of electrochemical sensor based on molecularly imprinted polymer and carbon nanotubes for the determination of carvedilol. Chemosensors 22 (2016) 1-15.
29. Wang, J. Analytical Electrochemistry, Wiley, New York, USA, 2006.
30. Hosseinian M, Najafpour G, Rajimpour A. Amperometric urea biosensor based on immobilized urease on polypyrrole and macroporous polypyrrole modified Pt electrode. Turkish Journal of Chemistry 43 (2019) 1063-1074.
31. Yılmaz B, Ekinci D. Voltammetric behavior of carvedilol in non-aqueous media and its analytical determination in pharmaceutical preparations. Reviews in Analytical Chemistry 30 (2011) 187–193.