The Prevalence of Neoplasm Diseases and Investigation of Some Biochemical Serum Parameters

Yıl 2021, Cilt: 8 Sayı: 2, 189 - 195, 30.06.2021

Hasan Karageçili , Emrah Yerlikaya , Mustafa Oğuzhan Kaya

https://doi.org/10.17350/HJSE19030000229

Öz

Aim: The aim of this work, investigating the skin, lung, and bone marrow-related cancer prevalence and biochemical serum parameters of all these cancer patients.
Materials and Methods: The skin, lung, and bone marrow cancer patient's biochemical serum data were examined retrospectively using a hospital information system.
Results: Basal cell carcinoma patients number were recorded as 155 with 63%, squamous cell carcinoma patients number were enrolled in73 with 30% and malign melanoma patients number were noted as 10 with 4%. Skin cancers were recorded to be the most seen cancer type in 246 patients with 22% between 2013-2017 years. All types of cancer patient's numbers were calculated as 1134 between these years. The very common incidences of basal cell carcinoma and squamous cell carcinoma cancers were observed on the upper part of the body, respectively on the face-cheek, nose, ear, eyelid, and lip. In this study, there was seen a statistically significant difference between skin cancer patient’s serum glucose, aspartate aminotransferase, alanine aminotransferase, sodium, bilirubin direct, bilirubin total, creatinine, urea level, and control group serum parameters level, p<0.05. The lung cancer patient numbers were recorded as 119 with 10.4 %, bone marrow patients numbers were enrolled in 113 with 10%. Two cancer groups were statistically different in terms of 5-years survival. Log Rank X2 = 8.68, p = 0.003, p<0.05.
Conclusions: We recorded that skin cancer types and regions on the upper parts of the body were more because of exposure to the sun. The lung cancer survival rate was lower than bone marrow cancer. Moreover, we strongly emphasized that measuring the biochemical serum parameters was statistically significant in the diagnosis of cancer patients.

Anahtar Kelimeler

Carcinoma, Malignant, Skin cancer, Lung, Incidence, Bone marrow

Destekleyen Kurum

Siirt University BAP

Proje Numarası

2017-SİÜSYO-66

Teşekkür

This study was supported by Siirt University Scientific Research Projects Coordination (2017-SİÜSYO-66).

Kaynakça

• 1. Nair M, Sandhu SS, Sharma AK. Cancer molecular markers: A guide to cancer detection and management. Semin Cancer Biol 2018; 52: 39–55.
• 2. Duartea AF, Pinto BS, Freitas A et al. Skin cancer healthcare impact: A nation-wide assessment of an administrative database. Cancer Epidemiol 2018; 56: 154–160.
• 3. Apalla Z, Lallas A, Sotiriou E et al. Epidemiological trends in skin cancer. Dermatol Pract Concept 2017;7(2):1.
• 4. Brunssen A, Waldmann A, Eisemann N et al. Impact of skin cancer screening and secondary prevention campaigns on skin cancer incidence and mortality: A systematic review. J Am Acad Dermatol 2017;76: 129-39.
• 5. O’Sullivan DE, Brenner DR, Demers PA et al. Indoor tanning and skin cancer in Canada: A meta-analysis and attributable burden estimation. Cancer Epidemiol 2019; 59: 1–7.
• 6. Cho EA, Moloney FJ, Cai H et al. Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER). Lancet 2013; 381:1835–43.
• 7. Chang NB, Feng R, Gao Z et al. Skin cancer incidence is highly associated with ultraviolet-B radiation history. Int J Hyg Envir Heal 2010; 213: 359–368.
• 8. Didona D, Paolino G, Bottoni U et al. Non Melanoma Skin Cancer Pathogenesis Overview. Biomedicines 2018; 6(1): 6.
• 9. Kansara S, Bell D, Weber R. Surgical management of non melanoma skin cancer of the head and neck. Oral Oncology 100 (2020) 1044853.
• 10. Ziebarth N.R. Lung cancer risk perception biases. Preventive Medicine 110 (2018) 16–23.
• 11. Götte M, Kovalszky I. Extracellular matrix functions in lung cancer, Matrix Biol (2017), https://doi.org/10.1016/j.matbio.2018.02.018.
• 12. Mu C.F, Shen J, Liang J, Zheng H.S, Xiong Y, Wei Y.H, Fanzhu Li. Targeted drug delivery for tumor therapy inside the bone marrow. Biomaterials 155 (2018) 191-202.
• 13. Kayabaşoğlu G. An Alternative Flap Approach For Auricle Reconstruction. Sakaryamj 2013; 3(1): 32-35.
• 14. Arıca S, Nazlıcan E, Özer C et al. The frequency and distribution of cancer cases in Hatay District in 2008. J Clin Exp Invest 2011; 2 (2): 192-195.
• 15. Eisemann N, Waldmann A, Geller AC et al. Non-Melanoma Skin Cancer Incidence and Impact of Skin Cancer Screening on Incidence. J Invest Dermatol 2014; 134: 43-50.
• 16. Armstrong BK, Cust AE. Sun exposure and skin cancer, and the puzzle of cutaneous melanoma A perspective on Fears et al. Mathematical models of age and ultraviolet effects on the incidence of skin cancer among whites in the United States. American Journal of Epidemiology 1977; 105: 420–427. Cancer Epidemiol 2017; 48: 147–156.
• 17. Rubió-Casadevall J, Hernandez-Pujol AM, Ferreira-Santos MC et al. Trends in incidence and survival analysis in non-melanoma skin cancer from 1994 to 2012 in Girona, Spain: A population-based study. Cancer Epidemiol 2016; 45: 6–10.
• 18. Egeler SA, Huang A, Johnson AR et al. Regional incidence of and reconstructive management patterns in melanoma and nonmelanoma skin cancer of the head and neck: A 3-year analysis in the inpatient setting. Journal of Plastic, Reconstructive and Aesthetic Surgery 2020; 73: 507-515.
• 19. Chougule A, Hussain S, Agarwal DP. Prognostic and diagnostic value of serum pseudocholinesterase serum aspartate transaminase, and serum alanine transaminase in malignancies treated by radiotherapy. J Cancer Res Ther 2008; 4(1).
• 20. Khazaei Z, Ghorat F, Jarrahi AM et al. Global incidence and mortality of skin cancer by histological subtype and ıts relationship with the human development ındex (HDI); An Ecology Study in 2018. World Cancer Research Journal 2019; 6: e1265.
• 21. AL-Janabi, AAHS, Ali ZQ, Noree ZM. Lactate dehydrogenase as an indicator of liver, muscular, and cancer diseases. J Coast Life Med 2015; 3(7): 543-546.
• 22. Ojo O.C, Asaolu M.F, Akinlua I, Oyeyemi A.O, Atiba A.S. Serum Marker Enzymes Activities in Cancer Patients. Journal of Chemistry and Biochemistry December 2016, Vol. 4, No. 2, 15-21.
• 23. Li X. et al. The effect of preoperative serum triglycerides and high-density lipoprotein-cholesterol levels on the prognosis of breast cancer. The Breast 32 (2017) 1-6.
• 24. Liu X. et al. Prognostic significance of pretreatment serum levels of albumin, LDH, and total bilirubin in patients with nonmetastatic breast cancer Carcinogenesis, 2015, Vol. 36, No. 2, 243–248.
• 25. McRee AL, Mays D, Kornides ML et al. Counseling About Skin Cancer Prevention Among Adolescents: What Do Parents Receive From Health Care Providers? J Adolescent Health 2017; 61: 533-536.