Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole
Yıl 2022,
, 175 - 186, 01.09.2022
Yurii Sameliuk
,
Andrii Kaplaushenko
,
Natalia Nedorezanıuk
,
Liusine Ostretsova
,
Feodosiia Diakova
,
Bogdan Gutyj
Öz
The purpose of this literature review was to systematize data from studies of the biological activity of 1,2,4-triazole derivatives with substituents in positions 4 and 5. The authors set the task of forming an idea of current directions in the selection of substitutions for 1,2,4-triazole based on research.
As a result of the study, 75 literature sources were analyzed. This made it possible to form a further vector in terms of searching for biologically active structures among 1,2,4-triazole derivatives. The review develops a modern approach to the search for biologically active substances among 1,2,4-triazole derivatives. Sys- tematized data on the nature of substituents in the core of 1,2,4-triazole, which affect a specific type of activity.
The search material was selected over the past decade with the highest number of citations at the time of literature analysis.
Destekleyen Kurum
Zaporizhzhia State Medical University, Faculty of Pharmacy, Department of physical and colloidal chemistry, Zaporizhzhia, Ukraine
Teşekkür
thanks to Hacettepe University Journal of Faculty of Pharmacy
Kaynakça
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- 4. Shcherbyna, R., Parchenko, V., Varynskyi, B., & Kaplaushenko, A. (2019). The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1, 2, 4-triazol-3-yl) thio) acetate substance. Current Issues In Pharmacy And Medical Sciences, 32(1), 5-9.
- 5. Varynskyi, B., & Kaplaushenko, A. (2019). The force degradation study of the morpholinium 2-((4-(2-methoxyphenyl)-5-(pyridin-4-YL)-4H-1,2,4-triazol-3-yl) Thio) Acetate. Indonesian Journal of Pharmacy, 30(1), 25.
- 6. Frolova, Y., Kaplaushenko, A., & Nagornaya, N. (2020). Design, synthesis, antimicrobial and antifungal activities of new 1, 2, 4-triazole derivatives containing 1h-tetrazole moiety. Journal of Faculty of Pharmacy of Ankara University, 44(1), 70-88.
- 7. Shcherbyna, R., Parchenko, V., Varynskyi, B., & Kaplaushenko, A. (2019). The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1, 2, 4-triazol-3-yl) thio) acetate substance. Current Issues In Pharmacy And Medical Sciences, 32(1), 5-9.
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Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole
Yıl 2022,
, 175 - 186, 01.09.2022
Yurii Sameliuk
,
Andrii Kaplaushenko
,
Natalia Nedorezanıuk
,
Liusine Ostretsova
,
Feodosiia Diakova
,
Bogdan Gutyj
Öz
The purpose of this literature review was to systematize data from studies of the biological activity of 1,2,4-triazole derivatives with substituents in positions 4 and 5. The authors set the task of forming an idea of current directions in the selection of substitutions for 1,2,4-triazole based on research.
As a result of the study, 75 literature sources were analyzed. This made it possible to form a further vector in terms of searching for biologically active structures among 1,2,4-triazole derivatives. The review develops a modern approach to the search for biologically active substances among 1,2,4-triazole derivatives. Sys- tematized data on the nature of substituents in the core of 1,2,4-triazole, which affect a specific type of activity.
The search material was selected over the past decade with the highest number of citations at the time of literature analysis.
Kaynakça
- 1. Varynskyi, B., & Kaplaushenko, A. (2020). Metabolism study of morpholinium 2-((4-(2-methoxyphenyl)-5-(pyridin-4-yl)-4-1, 2, 4-triazole-3-yl) thio) acetate. Current Issues in Pharmacy and Medical Sciences, 33(2), 72-75.
- 2. Oliinykov, D., Kaplaushenko, A., Trehub, S., & Kovalyova, K. Manufacture of spherical granules of isosorbide dinitrate with modified release. Journal of Faculty of Pharmacy of Ankara University, 44(3), 481-493.
- 3. Frolova, Y., Kaplaushenko, A., & Nagornaya, N. (2020). Design, synthesis, antimicrobial and antifungal activities of new 1, 2, 4-triazole derivatives containing 1H-tetrazole moiety. Journal of Faculty of Pharmacy of Ankara University, 44(1), 70-88.
- 4. Shcherbyna, R., Parchenko, V., Varynskyi, B., & Kaplaushenko, A. (2019). The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1, 2, 4-triazol-3-yl) thio) acetate substance. Current Issues In Pharmacy And Medical Sciences, 32(1), 5-9.
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