Cinnamomum verum: Biogenic Synthesis of Silver Nanoparticles and In Vitro Anticancer Activity on A-431 Cell Lines

Abstract

Human skin cancers are the most common type of cancer, especially among white individuals. Due to the rising incidence of cutaneous malignancies, various therapies have been developed. While surgical treatments remain the gold standard, innovative approaches are needed to reduce morbidity and mortality. This study explores the potential of green synthesized silver nanoparticles using Cinnamomum verum aqueous extract as an eco-friendly and cost effective alternative for skin cancer treatment. The plant extract served as a capping and reducing agent to biosynthesize silver ions into silver nanoparticles. Among the formulations, NP3 had the smallest particle size 220.5 nm and a zeta potential of -4.4 mV, as revealed by dynamic light scattering. Energy-dispersive X-ray analysis confirmed 26.18% silver content. The antiproliferative efficacy of NP3 was evaluated on A431 cell lines by cytotoxicity evaluation. The IC50 value for Cinnamomum verum extract was 57.92±0.25µg/ml, while biosynthesized NP3 had an improved IC50 of 45.30±0.72µg/ml, demonstrating significant antiproliferative activity. These findings suggest that biosynthesized silver nanoparticles could serve as an alternative therapy for managing skin cancer.

Keywords

• Cinnamomum verum
• A431cell lines
• skin cancer
• MTT assay
• Siver nanoparticles

References

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