Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model

Kiran Choudhari; Shivaraj Hiremath; Mallappa Shalavadi; Shubham Teli

doi:10.52794/hujpharm.1639845

Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model

Abstract

Scirpus kysoor, has been used to treat various illnesses, but its effects on diabetes and cholesterol levels have not been scientifically proven yet. The study investigated the antihyperlipidemic and antidiabetic effects of HESK (hydroethanolic extracts of Scirpus kysoor) in high fat diet (HFD)with streptozotocin induced diabetic rats. Six experimental groups were designated. Group I received 0.9% NaCl, while Groups II–VI were administered HFD (3 ml/kg), Glimepiride (10 mg/kg), or 100, 200, and 400 mg/kg HESK respectively. With the exception of Group I, all rats were fed HFD for 56 days and made diabetic by a single intraperitoneal injection of STZ (35 mg/kg) on day 28. Biochemical markers like Glucose, Cholesterol, Triglycerides, ALP, ALT, AST, HDL, LDL and Total Protein were assessed. Anthropometric parameters, including Body weight, Food intake, AC/TC ratio, abdominal and thoracic circumference were measured. At last of the study, the levels of antioxidant parameters (LPO, CAT, SOD, GSH & total thiols) and the histopathology of the liver and pancreas were evaluated. Results showed HESK significantly reduced glucose, cholesterol, triglycerides, ALP, ALT, AST, and LDL, while increasing HDL and total protein levels (p<0.001) as compared to the control group (HFD). Additionally, antioxidant markers improved, with increased SOD, GSH, catalase, and thiols and decreased LPO(p<0.001)as compared to the control group. Anthropometric parameters such as Body weight, Food intake, Abdominal Circumference (AC), Thoracic circumference (TC) and AC/TC ratio (p<0.001) increased as compared to the control group. Histopathological findings supported these outcomes, confirming HESK’s dose-dependent antihyperlipidemic and antidiabetic effects in the diabetic rat model.

Keywords

References

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Details

Primary Language

English

Subjects

Basic Pharmacology

Journal Section

Research Article

Authors

Kiran Choudhari ^*
0000-0003-0972-3144
India

Shivaraj Hiremath
0009-0006-2589-9771
India

Mallappa Shalavadi
0000-0002-7496-6372
India

Shubham Teli
0000-0002-0587-3260
India

Publication Date

June 1, 2026

Submission Date

February 27, 2025

Acceptance Date

April 13, 2026

Published in Issue

Year 2026 Volume: 46 Number: 2

DOI

https://doi.org/10.52794/hujpharm.1639845

IZ

https://izlik.org/JA38GL42KP

Cite

RIS / Bibtex

APA

Choudhari, K., Hiremath, S., Shalavadi, M., & Teli, S. (2026). Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model. Hacettepe University Journal of the Faculty of Pharmacy, 46(2), 112-125. https://doi.org/10.52794/hujpharm.1639845

AMA

1.Choudhari K, Hiremath S, Shalavadi M, Teli S. Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model. HUJPHARM. 2026;46(2):112-125. doi:10.52794/hujpharm.1639845

Chicago

Choudhari, Kiran, Shivaraj Hiremath, Mallappa Shalavadi, and Shubham Teli. 2026. “Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model”. Hacettepe University Journal of the Faculty of Pharmacy 46 (2): 112-25. https://doi.org/10.52794/hujpharm.1639845.

EndNote

Choudhari K, Hiremath S, Shalavadi M, Teli S (June 1, 2026) Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model. Hacettepe University Journal of the Faculty of Pharmacy 46 2 112–125.

IEEE

[1]K. Choudhari, S. Hiremath, M. Shalavadi, and S. Teli, “Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model”, HUJPHARM, vol. 46, no. 2, pp. 112–125, June 2026, doi: 10.52794/hujpharm.1639845.

ISNAD

Choudhari, Kiran - Hiremath, Shivaraj - Shalavadi, Mallappa - Teli, Shubham. “Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model”. Hacettepe University Journal of the Faculty of Pharmacy 46/2 (June 1, 2026): 112-125. https://doi.org/10.52794/hujpharm.1639845.

JAMA

1.Choudhari K, Hiremath S, Shalavadi M, Teli S. Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model. HUJPHARM. 2026;46:112–125.

MLA

Choudhari, Kiran, et al. “Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model”. Hacettepe University Journal of the Faculty of Pharmacy, vol. 46, no. 2, June 2026, pp. 112-25, doi:10.52794/hujpharm.1639845.

Vancouver

1.Kiran Choudhari, Shivaraj Hiremath, Mallappa Shalavadi, Shubham Teli. Antihyperlipidemic and Antidiabetic Activities of Hydroethanolic Extract of Scirpus Kysoor in a High Fat Diet With Low Dose Streptozotocin Induced Diabetes Mellitus Rat Model. HUJPHARM. 2026 Jun. 1;46(2):112-25. doi:10.52794/hujpharm.1639845