A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies

Merve Nenni; İzgi Bayraktar Alkan; Esra Demirtürk; Mustafa Sinan Kaynak; Kutay Demirkan; Mustafa Çelebier

doi:10.52794/hujpharm.2012089

A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies

Abstract

Sleep disorders in children can negatively impact their development and quality of life. While melatonin is commonly used to manage these issues, there are no FDA-approved formulations specifically designed for children, and traditional tablet forms can be challenging for these patients. This study aims to develop a patient-friendly melatonin syrup formulation suitable for personalized pediatric therapies. Each teaspoon contains 1.0 mg of melatonin, allowing for flexible and precise dosing customized to individual patient needs. Melatonin content was quantified using a reversed-phase HPLC method with UV/Visible detector (HPLC-UV/Vis) ifadesi ‘with UV/Visible detector (HPLC-UV/Vis) that was developed and validated in line with ICH Q2(R1), demonstrating selectivity, linearity (1.0–30.0 μg/mL; R²=0.999), and intra- and inter-day accuracy and precision within 2%. Stability studies demonstrated that the syrup remains stable and retains its potency for at least seven days at room temperature. This syrup formulation enhances palatability and ease of administration, potentially improving therapeutic outcomes in children with sleep disorders through personalized treatment approaches. The syrup can be easily prepared using commercially available melatonin tablets in hospital pharmacies or home settings, using safe pediatric excipients.

Keywords

Supporting Institution

No

Ethical Statement

No need

Thanks

No

References

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Details

Primary Language

English

Subjects

Pharmaceutical Analytical Chemistry

Journal Section

Research Article

Authors

Merve Nenni ^*
0000-0003-3165-1060
Türkiye

İzgi Bayraktar Alkan
0000-0002-2694-4072
Türkiye

Esra Demirtürk
0000-0002-8918-0073
Türkiye

Mustafa Sinan Kaynak
0000-0003-2917-2407
Türkiye

Kutay Demirkan
0000-0002-6427-5826
Türkiye

Mustafa Çelebier
0000-0001-7712-5512
Türkiye

Publication Date

September 1, 2026

Submission Date

August 5, 2026

Acceptance Date

August 12, 2026

Published in Issue

Year 2026 Volume: 46 Number: 3

DOI

https://doi.org/10.52794/hujpharm.2012089

IZ

https://izlik.org/JA42DR59MM

Cite

RIS / Bibtex

APA

Nenni, M., Bayraktar Alkan, İ., Demirtürk, E., Kaynak, M. S., Demirkan, K., & Çelebier, M. (2026). A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies. Hacettepe University Journal of the Faculty of Pharmacy, 46(3), 241-249. https://doi.org/10.52794/hujpharm.2012089

AMA

1.Nenni M, Bayraktar Alkan İ, Demirtürk E, Kaynak MS, Demirkan K, Çelebier M. A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies. HUJPHARM. 2026;46(3):241-249. doi:10.52794/hujpharm.2012089

Chicago

Nenni, Merve, İzgi Bayraktar Alkan, Esra Demirtürk, Mustafa Sinan Kaynak, Kutay Demirkan, and Mustafa Çelebier. 2026. “A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies”. Hacettepe University Journal of the Faculty of Pharmacy 46 (3): 241-49. https://doi.org/10.52794/hujpharm.2012089.

EndNote

Nenni M, Bayraktar Alkan İ, Demirtürk E, Kaynak MS, Demirkan K, Çelebier M (September 1, 2026) A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies. Hacettepe University Journal of the Faculty of Pharmacy 46 3 241–249.

IEEE

[1]M. Nenni, İ. Bayraktar Alkan, E. Demirtürk, M. S. Kaynak, K. Demirkan, and M. Çelebier, “A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies”, HUJPHARM, vol. 46, no. 3, pp. 241–249, Sept. 2026, doi: 10.52794/hujpharm.2012089.

ISNAD

Nenni, Merve - Bayraktar Alkan, İzgi - Demirtürk, Esra - Kaynak, Mustafa Sinan - Demirkan, Kutay - Çelebier, Mustafa. “A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies”. Hacettepe University Journal of the Faculty of Pharmacy 46/3 (September 1, 2026): 241-249. https://doi.org/10.52794/hujpharm.2012089.

JAMA

1.Nenni M, Bayraktar Alkan İ, Demirtürk E, Kaynak MS, Demirkan K, Çelebier M. A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies. HUJPHARM. 2026;46:241–249.

MLA

Nenni, Merve, et al. “A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies”. Hacettepe University Journal of the Faculty of Pharmacy, vol. 46, no. 3, Sept. 2026, pp. 241-9, doi:10.52794/hujpharm.2012089.

Vancouver

1.Merve Nenni, İzgi Bayraktar Alkan, Esra Demirtürk, Mustafa Sinan Kaynak, Kutay Demirkan, Mustafa Çelebier. A Simple and Reproducible Melatonin Syrup Formulation for Personalized Pediatric Therapies. HUJPHARM. 2026 Sep. 1;46(3):241-9. doi:10.52794/hujpharm.2012089