Panax ginseng C.A. Meyer’in Etkinliği ve Güvenliliği Üzerine Derleme

İşıl Nur Apaydın; Sevtap Aydın

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Panax ginseng C.A. Meyer’in Etkinliği ve Güvenliliği Üzerine Derleme

Abstract

Panax ginseng (Panax ginseng, C.A. Meyer) (P. ginseng) yüzyıllar boyunca özellikle Doğu Asya kültürlerinde geleneksel bitkisel ilaç olarak kullanılmaktadır. Yapılan araştırmalar P. ginseng’in öğrenme kabiliyetini geliştirdiğini, antidepresan etkisinin bulunduğunu, nörolojik fonksiyonları düzelttiğini ve kan dolaşımını düzenlediğini göstermektedir. Ayrıca karaciğerin korunması ve iyileşmesi üzerine etkili olduğu, erektil disfonksiyonunu düzelttiği, çeşitli kanser hücre gelişmesini inhibe edebildiği bildirilmektedir. Günümüze kadar P. ginseng’in farmakolojik özellikleri üzerine çok sayıda klinik araştırmalar yapılmış olmasında rağmen, birçok sistematik derleme bu ile ilgili verilerin hala yetersiz olduğunu ve klinik etkinlik için güçlü kanıtların bulunamadığını ortaya koymaktadır. P. ginseng’in uzun süredir kullanılması ve klinik çalışma sonuçları bitkinin ciddi bir güvenlilik kaygısı taşımadığını göstermektedir, ancak hipersensitivite reaksiyonları, mide-bağırsak problemleri ve uykusuzluk yapabileceği, ancak bu belirtiler hafif ve geri dönüşümlü etkilerdir. Klinik araştırmalarda etkileşimlerle ilgili olgu sunumlarının doğruluğu kanıtlanamamasına rağmen ilaç-bitki etkileşmeleri açısında dikkat edilmelidir. Yeterli veri olmadığı için hamilelik ve emzirme döneminde ve pediatrik gruplarda kullanılması önerilmemektedir. Bu derleme kapsamında P.ginseng’in geleneksel kullanımı, farmakokinetiği, farmakolojik etkileri, toksisitesi ve güvenli kullanımı tartışılmıştır.

Keywords

Panax ginseng C.A. Meyer’in Etkinliği ve Güvenliliği Üzerine Derleme

Abstract

Panax ginseng (Panax ginseng, C.A.Meyer) (P. ginseng) have been used as traditional herbal medicine for centuries, especially in Eastern Asian cultures. The research shows that P. ginseng develops learning ability, has antidepressant effect, ameliorates neurological functions, and regulates blood circulation. Moreover, it has been reported to be effective on liver protection and healing, to improve erectile dysfunction, to inhibit cell progression in various cancer cells. Despite the fact that numerous clinical studies have been conducted on the pharmacological properties of P. ginseng until today, several systematic reviews have revealed that related data is still inconclusive and strong evidence for clinical efficacy cannot be deduced. Due to the long-standing use of P. ginseng and the outcome of clinical trials, it seems not to have serious safety concerns, however it has been reported that it may couse hypersensitivity reactions, gastrointestiral disordes and insomnia. However, these symptoms are mild and reversible. Despite case reports on interactions can not be verified in clinical trials, drug-herbal interactions should be considered. Since there is not enough data, it is not recommended to use during pregnancy and lactation and in pediatric groups. In this review, the traditional use, the pharmacokinetics and pharmacological effects, toxicity and safety use of P. ginseng has been discussed.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Pharmacology and Pharmaceutical Sciences

Journal Section

Review

Authors

İşıl Nur Apaydın This is me
Türkiye

Sevtap Aydın ^*
Türkiye

Publication Date

January 15, 2018

Submission Date

June 2, 2017

Acceptance Date

November 16, 2017

Published in Issue

Year 2018 Volume: 38 Number: 1

IZ

https://izlik.org/JA35LT35AB

Cite

RIS / Bibtex

APA

Apaydın, İ. N., & Aydın, S. (2018). Panax ginseng C.A. Meyer’in Etkinliği ve Güvenliliği Üzerine Derleme. Hacettepe University Journal of the Faculty of Pharmacy, 38(1), 11-23. https://izlik.org/JA35LT35AB

AMA

1.Apaydın İN, Aydın S. Panax ginseng C.A. Meyer’in Etkinliği ve Güvenliliği Üzerine Derleme. HUJPHARM. 2018;38(1):11-23. https://izlik.org/JA35LT35AB

Chicago

Apaydın, İşıl Nur, and Sevtap Aydın. 2018. “Panax Ginseng C.A. Meyer’in Etkinliği Ve Güvenliliği Üzerine Derleme”. Hacettepe University Journal of the Faculty of Pharmacy 38 (1): 11-23. https://izlik.org/JA35LT35AB.

EndNote

Apaydın İN, Aydın S (January 1, 2018) Panax ginseng C.A. Meyer’in Etkinliği ve Güvenliliği Üzerine Derleme. Hacettepe University Journal of the Faculty of Pharmacy 38 1 11–23.

IEEE

[1]İ. N. Apaydın and S. Aydın, “Panax ginseng C.A. Meyer’in Etkinliği ve Güvenliliği Üzerine Derleme”, HUJPHARM, vol. 38, no. 1, pp. 11–23, Jan. 2018, [Online]. Available: https://izlik.org/JA35LT35AB

ISNAD

Apaydın, İşıl Nur - Aydın, Sevtap. “Panax Ginseng C.A. Meyer’in Etkinliği Ve Güvenliliği Üzerine Derleme”. Hacettepe University Journal of the Faculty of Pharmacy 38/1 (January 1, 2018): 11-23. https://izlik.org/JA35LT35AB.

JAMA

1.Apaydın İN, Aydın S. Panax ginseng C.A. Meyer’in Etkinliği ve Güvenliliği Üzerine Derleme. HUJPHARM. 2018;38:11–23.

MLA

Apaydın, İşıl Nur, and Sevtap Aydın. “Panax Ginseng C.A. Meyer’in Etkinliği Ve Güvenliliği Üzerine Derleme”. Hacettepe University Journal of the Faculty of Pharmacy, vol. 38, no. 1, Jan. 2018, pp. 11-23, https://izlik.org/JA35LT35AB.

Vancouver

1.İşıl Nur Apaydın, Sevtap Aydın. Panax ginseng C.A. Meyer’in Etkinliği ve Güvenliliği Üzerine Derleme. HUJPHARM [Internet]. 2018 Jan. 1;38(1):11-23. Available from: https://izlik.org/JA35LT35AB