Nanosüspansiyonlar: Hazırlama Yöntemleri ve Stabilite Sorunu

Abstract

Yeni keşfedilen etkin maddelerin büyük bir kısmı suda çözünmez ve biyoyararlanımları çok düşüktür. Sulu ortamdaki düşük çözünürlük sorununun üstesinden gelmek için geliştirilen farklı yaklaşımlardan birisi de nanosüspansiyonlardır ve son yıllarda, bu ilaç şekli, eşsiz özelliklerinden dolayı farmasötik alanda popülerlik kazanmıştır. Nanosüspansiyon, uygun sürfaktan ve/veya polimerler ile kararlı hale getirilmiş saf etkin madde partiküllerinin nano-boyutlu (<1000 nm, genellikle, 200-600 nm) kolloidal dağılımlarıdır. Nanosüspansiyonlar, çeşitli yöntemler (öğütme, yüksek basınçlı homojenizasyon, çöktürme vb.) kullanılarak başarıyla hazırlanmıştır. Bu derleme, nanosüspansiyonların özellikleri, kararlılığı, üstünlükleri ve sakıncaları ve aynı zamanda nanosüspansiyon hazırlama yöntemleri üzerine odaklanmaktadır.

Keywords

• Hazırlama yöntemleri
• nanosüspansiyonlar
• stabilite

Nanosuspensions: Preparation Methods and Stability Issue

Abstract

A large proportion of newly discovered active subtances are water insoluble and have very low bioavailability. One of the different approaches developed to overcome the issue of low solubility in aqueous media is nanosuspensions and in recent years, this dosage form has gained popularity in the pharmaceutical area because of their unique properties. Nanosuspension is nano-sized (<1000 nm, generally, 200-600nm) colloidal dispersions of pure active substance particles, which are stabilized by suitable surfactants and/or polymers. Nanosuspensions are successfully prepared using various methods such as media milling, high-pressure homogenization and precipitation techniques etc. This review focus on the properties, stability, advantages and disadvantages of nanosuspensions, and also, preparation methods for nanosuspensions. 

Keywords

• preparation methods
• Nanosuspensions
• stability

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