Organoklorlu Pestisitler, Poliklorlu Bifenilller ve Kahve Tüketimi ile Pankreas Kanseri Arasındaki İlişkinin Değerlendirilmesi

Abstract

Pankreas kanseri mortalite riski en yüksek kanserlerden biridir ve bu kansere yol açan risk faktörleri kesin olarak aydınlatılamamıştır. Gelişiminde genetik faktörlerin, özellikle de K-Ras geni mutasyonlarının önemli rol oynadığı belirtilmektedir. Yapılan araştırmaların bir kısmı sigara bağımlılarında ve diyabet hastalarında pankreas kanseri riskinin arttığını rapor etmektedir. Bazı pestisitlerin ise, laboratuvar hayvanlarında pankreas kanserine yol açtığı bildirilmiş ve tarım işçilerinde pankreas kanseri riskini arttığı yapılan epidemiyolojik çalışmalar ile gösterilmiştir. Yapılan sınırlı sayıda çalışmada, organoklorlu pestisitlere OC akut ve kronik maruziyetin oksidatif strese neden olabileceği; diyabet ve çeşitli metabolik hastalıkların gelişmesine ve pankreas kanserine yol açabileceği belirtilmiştir. Diğer taraftan, literatürde poliklorlu bifenillere maruziyetin PCB ve yüksek kahve tüketiminin de pankreas kanseri ile ilişkilendirildiği sınırlı sayıda çalışma bulunmaktadır. Bu derlemenin amacı OC ve PCB maruziyetinin ve yüksek miktarda kahve tüketiminin pankreas kanseriyle olan ilişkisini incelemektir.

Keywords

• Pankreas kanseri,pestisitler,mesleki maruziyet,organoklorlü bileşikler

Evaluation of the Relationship between Organochloride Insecticides, Polychlorinated Biphenyls and Coffee Consumption with Pancreatic Cancer

Abstract

Pancreatic cancer is a cancer type with very high mortality risk and the risk factors, which lead to pancreatic cancer are not definitely enlightened. In its development, genetic factors, particularly K-Ras gene mutations are suggested to play an important role. Some pesticides were identified as causes of pancreatic cancer in both laboratory animals and epidemiological studies have shown that pesticide exposure could increase the risk of pancreatic cancer in farm workers. Limited number of studies indicated that acute or chronic exposure to organochloride pesticides OC could cause oxidative stress, which might then lead to diabetes, other metabolic diseases and pancreatic cancer. On the other hand, few studies in literature have found a relationship between exposure to polychlorinated biphenyls PCBs , high coffee consumption and pancreatic cancer. The aim of this review is to elucidate the relationship between pancreatic cancer, OC and PCB exposure and high coffee consumption.

Keywords

• pancreatic cancer,pesticides,occupational exposure,organochlorine compounds

References

1. 1. National Cancer Institute. What is cancer? Web sayfası: http://www.cancer.gov/aboutcancer/what-is-cancer.
2. 2. Gültekin M, Boztaş G (Editors): Türkiye Kanser İstatistikleri 2009. Ankara: T.C.Sağlık Bakanlığı, Türkiye Halk Sağlığı Kurumu, Kanser Daire Başkanlığı, 2014. Web sayfası: http://kanser.gov.tr/Dosya/ca_istatistik/2009kanseraporu.pdf
3. 3. Türkiye İstatistik Kurumu. İstatistiklerle Türkiye. (TurkStat, Turkey in Statistics). Türkiye İstatistik Kurumu Matbaası, 2013.
4. 4. T.C. Sağlık Bakanlığı. Sağlık İstatistiği Yıllığı. Web sayfası: http://www.sagem.gov.tr/dosyalar/saglik_istatistikleri_2012.pdf
5. 5. Drake RL, Vogl W, Tibbitts AWM Richardson P: “Gray's anatomy for students.” Philadelphia: Elsevier/Churchill Livingstone, 2005: 288–290, 297, 303.
6. 6. Ryan DP, Hong TS, Bardeesy N: Pancreatic Adenocarcinoma. The New England Journal of Medicine 2014 371: 1039–1049.
7. 7. Ecobichon, D.J. “Toxic effects of pesticides.” Amdur, M.O., Doull, J., Klaassen, C.D,(Eds.), Casarett and Doull’s Toxicology: the Basic Science of Poisons 4th, New York: Pergamon. Ed 1991, 565–580.
8. 8. Kannan, K., Tanabe, S., Giesy, J.P., Tatsukawa, R. Organochlorine pesticides and polychlorinated biphenyls in foodstuffs from Asian and oceanic countries. Reviews of Environmental Contamination and Toxicology 1997, 152: 1-55.

9. 9. Porta, M., Malats, N., Jariod, M., Grimalt, J.O., Rifa, J., Carrato, A., Guarner, L., Salas, A., Santiago-Silva, M., Corominas, J.M., Andreu, M., Real, F.X. Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group. Lancet, 1999, 354: 2125-2129.
10. 10. Dich, J., Zahm, S.H., Hanberg, A., Adami, H.O. Pesticides and cancer. Cancer Causes Control, 1997, 8: 420-423.
11. 11. Ji, B.T., Silverman, D.T., Stewart, P.A., Blair, A., Swanson, G.M., Baris, D., Greenberg, R.S., Hayes, R.B., Brown, L.M., Lillemoe, K.D., Schoenberg, J.B., Pottern, L.M. Occupational exposure to pesticides and pancreatic cancer. American Journal of Industrial Medicine 2001 39: 92-99.
12. 12. Slebos, R.J.C., Hoppin, J.A., Tolbert, P.E. History, Histopathology, and Environmental Exposures in a K-ras and p53 in Pancreatic Cancer: Association with Medical Populationbased Study. Cancer Epidemiol Biomarkers Prevention 2000 9:1223-1232.
13. 13. Blair, A., Dosemeci, M., Heineman, E.F. :Cancer and other causes of death among male and female farmers from twenty-three states American Journal of Industrial Medicine 1993 23:729-732.
14. 14. Blair, A., Zahm, S.H. Herbicides and cancer: a review and discussion of methodologic issues. Recent Results Cancer Results 1990 120: 132-145.
15. 15. U.S. Environmental Protection Agency. Integrated Risk Information System (IRIS) on DDE, 1993.
16. 16. Kauppinen, T., Partanen, T., Degerth, R., Ojajarvi, A. Pancreatic cancer and occupational exposures. Epidemiology 1995, 6: 498-502.
17. 17. Andreotti, G., Laura, E., Freeman, B., Hou, L., Coble, J., Rusiecki, J., Hoppin, J.A., Silverman, D.T., Michael C.R. Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort. International Journal of Cancer 2009, 124: 2495- 2500
18. 18. Garabrant, D.H., Held, J., Langholz, B., Peters, J.M., Mack, T.M. DDT and related compounds and risk of pancreatic cancer. Journal of the National Cancer Institute1992, 84: 764-771.
19. 19. Mack, T.M., Paganini-Hill, A. Epidemiology of pancreas cancer in Los Angeles. Cancer 1981, 47: 1474-1484
20. 20. Silverman, D.T., Schiffman, M., Everhart, J., Goldstein, A., Lillemoe, K.D., Swanson, G.M., Schwartz, A.G., Brown, L.M., Greenberg, R.S., Schoenberg, J.B., Pottern, L.M., Hoover, R.N., Fraumeni, J.F. Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer. British Journal of Cancer 1999, 80: 1830-1837.
21. 21. Bosch de Basea, M., Porta, M., Alguacil, J., Puigdomènech, E., Gasull, M., Garrido, J.A., López, T.; PANKRAS II Study Group. Relationships between occupational history and serum concentrations of organochlorine compounds in exocrine pancreatic cancer. Occupational Environment Medicine 2011, 68: 332-338.
22. 22. Gasull, M., Porta, M., Pumarega, J., Vioque, J., Bosch de Basea, M., Puigdomènech, E., Morales, E., Grimalt, J.O., Malats, N. The relative influence of diet and serum concentrations of organochlorine compounds on K-ras mutations in exocrine pancreatic cancer. Chemosphere 2010, 79: 686-697.
23. 23. Cocco, P., Fadda, D., Billai, B., D'Atri, M., Melis, M., Blair, A. Cancer Mortality among Men Occupationally Exposed to Dichlorodiphenilychloroethane, Cancer Results 2005, 65: 9588-9894.
24. 24. Logan, J.A. The Sardinian project: an experiment in the eradication of an indigenous malarious vector. Baltimore (MD): The Johns Hopkins Press, 1953.
25. 25. Position Paper of the American Council on Science and Health: Public Health Concerns about Environmental Polychlorinated Biphenyls (PCBs). Ecotox Environ Safety 1997, 38: 71-160.
26. 26. Knerr, S., Schrenk, D. Carcinogenicity of “Non-Dioxinlike” Polychlorinated Biphenyls. Critical Reviews in Toxicology, 2006, 36: 663-694.
27. 27. NTP (National Toxicology Program) Technical Report On The Toxicology and Carcinogenesis Studies of 2,3´,4,4´,5-pentachlorobiphenyl (PCB 118) in Female Harlan Sprague-Dawley Rats , cas no. 31508-00-6.
28. 28. NTP (National Toxicology Program) Technical Report on the Toxicology an Carcinogenesis Studies of 2,3,7,8 Tetrachloroodibenzo-p-dioxin (TCDD) in Female Harlan Sprague- Dawley Rats. No.06-4468, 2006.
29. 29. Kneer, S., Schrenk, D. Carcinogenecity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in experimental models, Molecular Nutrition and Food Research 2006, 50: 897-907.
30. 30. Katsuhiko, Y., Tiwanda, M., Julie, F., Bo, C., Shyama,l P., Walker, N.J., Vos, J.G., Moore, J.A, Zinkl, J.G. Effects of 2,3,7,8- tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals. Environmental Health Perspectives, 1973, 5: 149-162.
31. 31. Kutz, F.W, Strassman, S.C. Residues of polychlorinated biphenyls in the general population of the United States. Paper presented at the Procedings of the National Conference on Polychlorinated Biphenyls, Chicago: Conference Proceedings, EPA. 560/6-75-004, 1975, 139-148.
32. 32. Porta, M., López, T., Pumarega, J., Jariod, M., Crous-Bou, M., Marco, E., Rifà, J, Grimalt, J.O., Malats, N., Real, F.X.; PANKRAS II Study Group. In pancreatic ductal adenocarcinoma blood concentrations of some organochlorine compounds and coffee intake are independently associated with KRAS mutations. Mutagenesis 2009, 24: 513- 521
33. 33. Mussatto, S.I., Machado, E.M.S., Martins, S., Teixeira, J.A. Production, Composition, and Application of Coffee and Its Industrial Residues. Food and Bioprocess Technology 2011, 4: 661-672.
34. 34. Here Are the Countries That Drink the Most Coffee—the U.S. Isn't in the Top 10. Web sayfası: Web sayfası: http://www.theatlantic.com/business/archive/2014/01/here-are-thecountries-that-drink-the-most-coffee-the-us-isnt-in-the-top-10/283100/.
35. 35. Yıldız, M.C. Kahvehanelerin Sosyal Hayattaki Yeri. Fırat Üniversitesi Sosyal Bilimler Dergisi 1996 8: 157-165.
36. 36. Woutersen, R.A., van Garderen-Hoetmer, A., Bax, J., Scherer, E. Modulation of dietary fat-promoted pancreatic carcinogenesis in rats and hamsters by chronic coffee ingestion. Carcinogenesis 1989, 10: 311-324
37. 37. Woutersen, R.A., Van Garderen-Hoetmer, A., Bax, J., Scherer, E. Modulation of putative preneoplastic foci in exocrine pancreas of rats and hamsters. Interaction of dietary fat and coffee. Digestive Diseases and Sciences 1989, 34: 789-796.
38. 38. Nishi, M., Ohba, S., Hirata, K. Hirotsugu Miyake Dose-response Relationship between Coffee and the Risk of Pancreas Cancer. Japan Journal of Clinical Oncology 1996, 26: 42-48.
39. 39. Parker, L.A., Lumbreras, B., Lopez, T., Hernández-Aguado, I., Porta, M. How useful is it clinically to analyse the K-ras mutational status for the diagnosis of exocrine pancreatic cancer? A systematic review and meta-analysis. European journal of clinical investigation 2011, 41: 793-805.