Bis-benzamid Türevlerinin Sentezi, Antibakteriyel Aktivitesi ve Fotofiziksel Özellikleri

Abstract

Bu çalışmada, 1,12-diaminododekan ve iki farklı açil klorür bileşiğinin reaksiyonu ile N,N'-(dodekan-1,12-diil)bis(2,4-diklorobenzamid) ve N,N'-(dodekan-1,12-diil)bis(4-bromobenzamid) olmak üzere yeni bis-benzamidler sırasıyla %88 ve %92 verimle sentezlendi. Moleküler yapıları 1H NMR, 13C NMR ve FT-IR teknikleri kullanılarak karakterize edildi. Sentezlenen bileşiklerin antibakteriyel aktiviteleri Staphylococcus aureus ATCC 25923 ve Escherichia coli ATCC 25922 suşlarına karşı tarandı. Ayrıca, CH2Cl2 ve CHCl3 içindeki ürünlerin fotofiziksel özellikleri UV-vis spektroskopisi kullanılarak incelendi. Bileşik 3a, çözücü polaritesinin artmasıyla yaklaşık 31 nm'de pozitif solvatokromizm gösterdi.

Keywords

• Antibakteriyel aktivite
• Bis-benzamid
• Fotofiziksel özellik

Project Number

BAP 2020-1-AP5-4097

Synthesis, Antibacterial Activity and Photophysical Properties of Bis-benzamide derivatives

Abstract

In this study, N,N’-(dodecane-1,12-diyl)bis(2,4-dichlorobenzamide) and N,N’- (dodecane-1,12-diyl)bis(4-bromobenzamide) as new bis-benzamides were syn- thesized by reaction of 1,12-diaminododecane and two different acyl chloride compounds in 88% and 92% yield, respectively. Their molecular structures were characterized using 1H NMR, 13C NMR and FT-IR techniques. Antibacterial activities of the synthesized compounds were screened against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 strains. Moreover, pho- tophysical properties of the products in CH Cl and CHCl were investigated us- 2 2 3 ing UV-vis spectroscopy. The compound 3a exhibited positive solvatochromism about 31 nm by increasing of solvent polarity.

Keywords

• Antibacterial activity
• Bis-benzamide
• Photophysical property

Supporting Institution

Mersin University Research Fund

Project Number

BAP 2020-1-AP5-4097

Thanks

This work was funded by Mersin University Research Fund (Project No: BAP 2020-1-AP5-4097).

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