Epigenetik Etkileri Olan Endokrin Bozucu Kimyasal Maddeler: Bisfenol A

Yıl 2016, Sayı: 2, 186 - 203, 01.06.2016

Pınar Erkekoğlu Belma Koçer-gümüşel

Öz

Son yıllarda epigenetik mekanizmaların gen ifade değişikliklerine neden olduğu ve bu değişikliklerin de başta kanser olmak üzere birçok hastalığın ortaya çıkmasında rol oynadığı çok sayıda kapsamlı çalışma ile gösterilmiştir. İnsanların yaygın olarak maruz kaldığı bazı çevresel kirleticilerin epigenetik değişikliklere neden olarak bazı hastalıkların patogenezinde rol oynadıklarını gösteren veriler bulunmaktadır. Bisfenol A BPA en yaygın maruz kalınan çevresel kirleticilerden olup, başta plastik sanayi olmak üzere endüstride pek çok alanda kullanımı olan bir kimyasal maddedir. BPA’nın yaşamın farklı dönemlerinde farklı epigenetik etkilerinin bulunduğu ve bu etkilerin fertilite ve kanser gelişimi gibi geniş bir yelpazede sonuçlarının olduğu bilinmektedir. Bu derleme kapsamında epigenetik mekanizmalar incelenecektir ve BPA’nın epigenetik etkilerinin değerlendirildiği in vitro ve in vivo çalışmaların sonuçları sunulacaktır.

Anahtar Kelimeler

bisfenol A, epigenetik, DNA metilasyonu, histon modifikasyonu, imprinting

Epigenetic effects of endocrine disrupting chemicals: Bisphenol A

Öz

In the last decade, several comprehensive studies showed that epigenetic mechanisms could alter gene expressions and this phenomenon could lead to numerous diseases, particularly to cancer. Data indicate that some environmental contaminants, to which humans are widely exposed to, can cause epigenetic alterations. These alterations can play roles in the pathogenesis of some diseases. Bisphenol A BPA is one of the most abundant environmental contaminants and it is a chemical widely used in several fields, specifically in plastic industry. It is known that BPA has epigenetic effects in different periods of life and these effects have wide range of outcomes, like affecting fertility and cancer promotion. In this review, we will mainly focus on epigenetic mechanisms and the results of in vitro and in vivo studies, in which .the epigenetic effects of BPA were evaluated, will be presented.

Anahtar Kelimeler

bisphenol A, epigenetics, DNA methylation, histone modification, imprinting

Kaynakça

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