Organoklorlu Pestisitler, Poliklorlu Bifenilller ve Kahve Tüketimi ile Pankreas Kanseri Arasındaki İlişkinin Değerlendirilmesi

Year 2016, Issue: 1, 69 - 88, 01.01.2016

Büşra Özyurt Pınar Erkekoğlu

Abstract

Pankreas kanseri mortalite riski en yüksek kanserlerden biridir ve bu kansere yol açan risk faktörleri kesin olarak aydınlatılamamıştır. Gelişiminde genetik faktörlerin, özellikle de K-Ras geni mutasyonlarının önemli rol oynadığı belirtilmektedir. Yapılan araştırmaların bir kısmı sigara bağımlılarında ve diyabet hastalarında pankreas kanseri riskinin arttığını rapor etmektedir. Bazı pestisitlerin ise, laboratuvar hayvanlarında pankreas kanserine yol açtığı bildirilmiş ve tarım işçilerinde pankreas kanseri riskini arttığı yapılan epidemiyolojik çalışmalar ile gösterilmiştir. Yapılan sınırlı sayıda çalışmada, organoklorlu pestisitlere OC akut ve kronik maruziyetin oksidatif strese neden olabileceği; diyabet ve çeşitli metabolik hastalıkların gelişmesine ve pankreas kanserine yol açabileceği belirtilmiştir. Diğer taraftan, literatürde poliklorlu bifenillere maruziyetin PCB ve yüksek kahve tüketiminin de pankreas kanseri ile ilişkilendirildiği sınırlı sayıda çalışma bulunmaktadır. Bu derlemenin amacı OC ve PCB maruziyetinin ve yüksek miktarda kahve tüketiminin pankreas kanseriyle olan ilişkisini incelemektir.

Keywords

Pankreas kanseri, pestisitler, mesleki maruziyet, organoklorlü bileşikler

Evaluation of the Relationship between Organochloride Insecticides, Polychlorinated Biphenyls and Coffee Consumption with Pancreatic Cancer

Abstract

Pancreatic cancer is a cancer type with very high mortality risk and the risk factors, which lead to pancreatic cancer are not definitely enlightened. In its development, genetic factors, particularly K-Ras gene mutations are suggested to play an important role. Some pesticides were identified as causes of pancreatic cancer in both laboratory animals and epidemiological studies have shown that pesticide exposure could increase the risk of pancreatic cancer in farm workers. Limited number of studies indicated that acute or chronic exposure to organochloride pesticides OC could cause oxidative stress, which might then lead to diabetes, other metabolic diseases and pancreatic cancer. On the other hand, few studies in literature have found a relationship between exposure to polychlorinated biphenyls PCBs , high coffee consumption and pancreatic cancer. The aim of this review is to elucidate the relationship between pancreatic cancer, OC and PCB exposure and high coffee consumption.

Keywords

pancreatic cancer, pesticides, occupational exposure, organochlorine compounds

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