Beyine İlaç Tașınması: Truva Atı Teknolojisi

Yıl 2014, Sayı: 1, 1 - 16, 01.01.2014

Selin S. Doğan Seçil Toktaş Yılmaz Çapan

Öz

Beyine İlaç Taşınmasında Kullanılan Taşıyıcı Sistemler, Ankara, 2013. KBE, beyni toksik ve zararlı bileşiklerden koruyarak homeostazı sağlayan, aynı zamanda pek çok etkin maddenin beyindeki hedef bölgelere ulaşmasını kısıtlayan en önemli faktördür. Tedaviyi sınırlayan bu fizyolojik bariyerin sebep olduğu engeli ortadan kaldırmak, ancak geliştirilen yeni stratejilerle mümkün olmaktadır. Nano boyutlu kolloidal sistemler, santral sinir sistemi hastalıklarının tedavisinde pasif ve aktif hedeflendirme yoluyla umut vaat eden yaklaşımlar olarak yer almaktadır. Bu yaklaşımlar arasında reseptör aracılı taşıyıcı RAT sistemler dikkat çekmektedir. Reseptörlere hedeflendirilmek üzere geliştirilen Truva Atı / Molecular Trojan Horse MTH teknolojisi sayesinde büyük moleküllü ilaçların beyine taşınmasına olanak sağlanmıştır. Hedeflendirilmiş taşıyıcı sistemlerin SSS’de kullanımları ile ilgili araştırmalar, günümüzde beyin kanseri, inme, Alzheimer, Parkinson, beyin travması gibi hastalıklar üzerinde yoğunlaşmaktadır. Bu çalışmanın amacı, kolloidal sistemlerin hedeflendirilmesinde kullanılan yaklaşımların ve güncel çalışmaların değerlendirilmesi ile yeni stratejilerin belirlenmesine olanak sağlamaktır.

Anahtar Kelimeler

İlaç hedeflendirme, kan-beyin engeli, nanopartiküler sistemler, Truva atı

Beyine İlaç Tașınması: Truva Atı Teknolojisi

Öz

Delivery Systems for Brain Drug Targeting, Ankara, 2013. Blood-brain barrier is the main factor which maintains homeostasis by protecting brain from toxic and harmful compounds, but it also represents the main limiting factor for a number of drug molecules to reach the aimed areas in brain. The only way to overcome this treatment-limiting obstacle could be reached by the help of new strategies. Nanoscale colloidal systems are promising strategies in the treatment of central nervous system CNS diseases by passive and active targeting. Receptor mediated transport systems RMT are in the spotlıght of targeting strategies.By the help of Molecular Trojan Technology, which is developed for receptor targeting, large molecule drugs will be transported to brain. Nowadays, research interest in targeted delivery systems in the treatment of CNS disorders has been focused on brain cancer, stroke, Alzheimer’s disease, Parkinson disease. Therefore, the aim of this present review is to evaluate the targeting approaches of colloidal systems and current studies for the development of new strategies.

Anahtar Kelimeler

Drug targeting, blood-brain barrier, nanoparticulate systems, Trojan horse

Kaynakça

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