Kanser Tedavisinde Lenfatik Hedeflendirme

Year 2012, Issue: 1, 67 - 90, 01.01.2012

Özge Çevik Uğur Aydın R. Neslihan Gürsoy

Abstract

Kanser; kontrolsüz bölünen ve diğer dokulara yayılabilme özelliği olan anormal hücrelerin oluşturduğu hastalıklar için kullanılan bir terimdir. Kanser tedavisinde radyoterapi, ameliyat ve kemoterapi gibi yöntemler kullanılır. Kemoterapi; kanser hastalarında önemli yan etkilere neden olur. Bu nedenle; tümörlü dokuya özgü ilaç taşıyıcı sistemlere ihtiyaç duyulur. İlacın sağlıklı dokularda daha az birikmesinin ve tümörlü bölgede tercihen yoğunlaşmasının bir sonucu olarak ilaç toksisitesi azalır. Bu sistemlere örnek olarak; lipozomlar, miseller, mikro-nanopartiküler sistemler verilebilir. Kanser hücreleri vücudun diğer organlarına kan ve lenf yoluyla yayılırlar. İlacın lenfatik sisteme hedeflendirilmesinin bir sonucu olarak kanser hücrelerinin çevre dokulara yayılması önlenebilir. Bu derlemede öncelikle; kanser hakkında temel bilgiler verilmekte; daha sonra ise; bu konuda yapılmış güncel çalışmalar ve araştırmalar ışığında kanser tedavisinde ilacın hedeflendirilmesinin önemi ve lenfatik hedeflendirmeden nasıl yararlanılabileceği anlatılmaktadır.

Keywords

Kanser, Kanserde Hedeflendirme, Yeni İlaç Taşıyıcı Sistemler, Lenfatik Hedeflendirme

Lymphatic targeting in Cancer Therapy

Abstract

Cancer is a term used for diseases of uncontrollable self-division of abnormal cells, which are able to invade other tissues. Radiotherapy, surgery and chemotherapy applications are in cancer treatment. Chemotherapy can cause many side effects in cancer patients. Therefore, tumor tissue-specific drug carrier systems are needed. Drug toxicity is reduced as a consequence of preferential accummulation at target sites and lower concentration in healthy tissues. Examples of these systems are liposomes, micelles, micro-nanoparticulate systems. Cancer cells can spread to other parts of the body through the blood and lymphatic systems. Spread of cancer cells into surrounding tissues can be prevented by drug targeting to the lymphatic system. In this context, basic information about cancer is given then, in the view of current studies, importance of targeting and advantages of lymphatic targeting in cancer therapy are explained.

Keywords

Cancer, Targeting in Cancer Therapy, New Drug Delivery Systems, Lymphatic Targeting

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