Ağızda Dağılan Tabletler II: In Vitro ve In Vivo Değerlendirilmeleri

Year 2011, Issue: 1, 59 - 70, 01.01.2011

Senem Sevtap Ölmez İmran Vural , Selma Şahin Aygün Ertuğrul Yılmaz Çapan

Abstract

Ağızda dağılan tebletler ADT hasta uyuncu üzerindeki belirgin etkilerinden dolayı oral katı dozaj şekilleri olarak dikkat çekicidirler. ADTler suya gereksinim olmadan tükürükte hızla dağılır ve/veya çözünür ve yutma zorluğu olanlar için üstünlük sağlar. ADTlerin karakterizasyonu için standart bir sistem yok gibi gözükmektedir. ADTlerin değerlendirilmesi friyabilite, sertlik, ıslanma zamanı, su absorpsiyon oranı, in vitro dağılma testi ve çözünme testi ile yapılabilir. Bu derleme, ADTlerin in vitro kalite kontrol testlerini ve klinik çalışmalarını özetlemektedir.

Keywords

Ağızda dağılan tabletler, değerlendirme teknikleri, dağılma testi, klinik çalışmalar

Orally disintegrating Tablets II: In Vitro and In Vivo Evaluations

Abstract

Orally disintegrating tablets ODTs are attractive oral solid dosage forms as it has significant impact on the patient compliance. ODTs disintegrate and/or dissolve rapidly in the saliva without the need for water and offer an advantage for populations who have difficulty in swallowing. There seems to be lack of a standardized system to characterize ODTs. Evaluation of ODTs can be done by friability, hardness, wetting time, water absorption ratio, in vitro disintegration test and dissolution test. The current article summarizes in vitro quality control tests and clinical studies for ODTs.

Keywords

Orally disintegrating tablets, evaluation techniques, disintegration test, clinical studies

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