Kemoterapi, Serbest Radikaller ve Oksidatif Stres

Yıl 2011, Sayı: 2, 137 - 150, 01.06.2011

Suna Sabuncuoğlu Hilal Özgüneş

Öz

Antineoplastik ilaçlar biyolojik sistemde oksidatif stres oluşumunu artırmaktadır. Kanser kemoterapisi sırasında hücresel hedeflere saldırabilen çok sayıda serbest radikal aracılığıyla oksidatif stres ortaya çıkmaktadır. Dolayısıyla kemoterapi, biyolojik sistemde çeşitli yan etkilere neden olmaktadır. Yüksek doz kemoterapi uygulanan hastalarda, plazma antioksidan konsatrasyonu azalma göstermektedir. Kemoterapi sırasında kullanılan antioksidanlar, oksidatif stres ile meydana gelen radikallerin oluşumunu azaltarak tedavi etkiliğini artırabilir. Bu derlemede, kemoterapi, oksidatif stres ve antioksidanlar arasındaki ilişki değerlendirilmiştir.

Anahtar Kelimeler

kemoterapi, oksidatif stres, antioksidanlar

Chemotherapy, Free Radicals and Oxidative Stress

Öz

Antineoplastic agents induce oxidative stress in biological systems. During cancer chemotherapy, oxidative stres is induced by numerous free radicals that can attack many cellular targets. Thereby, chemotherapy causes several side effects on biological system. In patients undergoing high-dose chemotherapy, the plasma antioxidant concentration has been shown to decrease. The use of anti-oxidants during chemotherapy may enhance therapy efficiency by reducing the generation of oxidative stress-induced radicals. In this review, the relation between chemotherapy, oxidative stres and antioxidants is evaluated.

Anahtar Kelimeler

chemotherapy, oxidative stress, antioxidants

Kaynakça

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