Sternbergia sicula, S. lutea ve Pancratium maritimum Ekstrelerinin In vitro Sitotoksik Aktiviteleri

Yıl 2010, Sayı: 1, 41 - 48, 01.01.2010

Gülen İrem Kaya , Buket Sarıkaya Derya Çiçek Nehir Ünver Somer

Öz

S.lutea L. Ker-Gawl ex Sprengel, S sicula Tineo ex Guss. ve Pancratium. maritimum L. bitkilerinin soğanları ve toprak üstü kısımlarına ait n-hekzan, etilasetat, etanol ve su ekstrelerinin sitotoksik aktiviteleri brine shrimp Artemia salina Leach. yöntemi ile tayini edilmiştir. Sonuç olarak bütün bitkilerin soğanlarından hazırlanan etanol ekstreleri belirgin aktivite göstermiştir. Ancak bitkilerin toprak üstü kısımlarından hazırlanan n-hekzan, etilasetat ve etanol ekstrelerinin hiçbirinde aktivite bulunmamıştır. P. maritimum bitkisinin soğan ve toprak üstü su ekstreleri aktif çıkarken, S. sicula soğanları ve S. lutea toprak üstü kısımlarından hazırlanan su ekstreleri belirgin sitotoksik aktivite göstermiştir.

Anahtar Kelimeler

S.lutea, S sicula, P. maritimum, Brine shrimp, Sitotoksik aktivite

In vitro Cytotoxic Activity of Sternbergia sicula, S. lutea and Pancratium maritimum Extracts

Öz

The cytotoxic activity of the n-hexane, ethyl acetate, ethanolic and aqueous extracts of the bulbs and aerial parts of S.lutea L. Ker-Gawl ex Sprengel, S sicula Tineo ex Guss. and P. maritimum L. were determined using the brine shrimp Artemia salina Leach. lethality bioassay. As a result, all of the ethanolic extracts of the bulbs showed significant activity. However, none of the n-hexane, ethyl acetate, ethanolic extracts of the aerial parts were active against Artemia salina Leach. The aqueous extracts of bulbs and aerial parts of P. maritimum were found to be active whereas aqueous extracts prepared from S. sicula bulbs and aerial parts of S. lutea showed significant activity.

Anahtar Kelimeler

S.lutea, S sicula, P. maritimum, Brine Shrimp, Cytotoxic activity

Kaynakça

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