Characteristics and Analytical Methods of Novel PDE5 Inhibitor Avanafil: An Update

Yıl 2022, Cilt: 42 Sayı: 2, 134 - 147, 01.06.2022

Alankar Shrivastava

https://doi.org/10.52794/hujpharm.1017182

Cited By: 3

Öz

Background: Erectile dysfunction (ED) affects middle and older age and occurrence increasing with age of men. PDE5 inhibitors are commonly used for the treatment of ED. The incidences of adulteration of PDE5 inhibitors with herbal aphrodisiacs is evident in almost every part of world. Avanafil (AVA) is novel PDE5 inhibitor with advantage of fast action.
Material and Method: The literatures and various analytical methods presented in this review was obtained by searching various databases like pubmed, medline, eurekaselect, sciencedirect, wiley and taylor and francis journals. The services of google scholar were also utilized for searching some literature. The literature search was performed to summarize characteristics, synthesis and analytical methods for determination of AVA.
Result: Different spectrophotometry methods, chromatography and ion mobility spectrometry methods are available in the method. The possibility for the development of green analytical method is also discussed.
Conclusion: The various analytical methods and characteristics of AVA is described. The methods for determination as adulterants and in pharmaceutical formulations including stability indicating methods.

Anahtar Kelimeler

Spectrophotometry, chromatography, erectile dysfunction, avanafil, adulteration analysis

Characteristics and Analytical Methods of Novel PDE5 Inhibitor Avanafil: An Update

Öz

Erectile dysfunction (ED) affects middle and older age and occurrence increasing with age of men. PDE5 inhibitors are commonly used for the treatment of ED. The incidences of adulteration of PDE5 inhibitors with herbal aphrodisiacs is evident in almost every part of world. Avanafil (AVA) is novel PDE5 inhibitor with advantage of fast action. The literatures and various analytical methods presented in this review was obtained by searching various databases like pubmed, medline, eurekaselect, sciencedirect, wiley and taylor and francis journals. The services of google scholar were also utilized for searching some literature. The literature search was performed to summarize characteristics, synthesis and analytical methods for determination of AVA. Different spectrophotometry methods, chromatography and ion mobility spectrometry methods are available in the method. The possibility for the development of green analytical method is also discussed. The various analytical methods and characteristics of AVA is described. The methods for determination as adulterants and in pharmaceutical formulations including stability indicating methods.

Anahtar Kelimeler

chromatography, erectile dysfunction, avanafil, adulteration analysis, Spectrophotometry

Kaynakça

• Reference1 Mitidieri E, Cirino G, d'Emmanuele di Villa Bianca R, Sorrentino R. Pharmacology and perspectives in erectile dysfunction in man. Pharmacol Ther. 2020;208:107493. DOI:10.1016/j.pharmthera.2020.107493.
• Reference2 Razdan S, Greer AB, Patel A, Alameddine M, Jue JS, Ramasamy R. Effect of prescription medications on erectile dysfunction. Postgrad Med J. 2018;94(1109):171-178. DOI:10.1136/postgradmedj-2017-135233.
• Reference3 Ahmed WS, Geethakumari AM, Biswas KH. Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors. Biomed Pharmacother. 2021;134:111128. DOI:10.1016/j.biopha.2020.111128.