N’-(2-(5-((Theophylline-7-yl)methyl)- 4-ethyl-1,2,4-triazole-3-ylthio)acetyl) isonicotinohydrazide As Antitubercular Agents

Year 2022, Volume: 42 Issue: 3, 149 - 155, 01.09.2022

Andrey Gotsulya , Vladimir Zazharskyı , Volodymyr Parchenko , Pavel Davydenko , Oleg Kulıshenko , Tetyana Brytanova

https://doi.org/10.52794/hujpharm.1011368

Cited By: 3

Abstract

The paper presents the results of histological studies of tuberculosis in rabbits in an experimental model with comparative treatment with isoniazid and N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide. The calculated dose of N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotino-hydrazide for subcutaneous administration indicates its prospects for veterinary practice as an effective and safe tuberculocidal drug.

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