Alzheimer Hastalığı ve Anti-Alzheimer Etkili Bileşiklerin Yapılarının Araştırılması

Year 2023, Volume: 43 Issue: 2, 150 - 173, 01.06.2023

Özden Tarı , Ramazan Yağmurtaşan

https://doi.org/10.52794/hujpharm.1175099

Cited By: 2

Abstract

Demansın en yaygın şekli olan Alzheimer hastalığı, hafıza kaybı ve diğer bilişsel problemler ile karakterize karmaşık bir hastalıktır. Artan prevalansa sahip olan Alzheimer hastalığının fizyopatolojisinin anlaşılması ve bu hastalığın tedavisinde etkin olan bileşiklerin yapılarının araştırılması, yeni etkin ilaç moleküllerinin geliştirilmesine yardımcı olacaktır. Bu anlamda hastalık üzerinde etkili olan hipotezlerin, etkin olan bileşiklerin yapısının ve etki mekanizmalarının araştırılması büyük önem taşımaktadır. Son yıllarda yapılan araştırmalarda, hastalığın patolojisinde etkili olan hipotezlerin birden fazlasını etkileyebilen daha güçlü bileşikler elde edilmeye odaklanıldığı görülmektedir. Bu derleme çalışmasında, Alzheimer hastalığının patolojisinde rol oynayan önemli hipotezler ile bu hipotezler üzerinden anti-Alzheimer etkinliği kanıtlanmış ilaç etken maddelerinin yapıları ortaya konulmuştur.

Keywords

Alzheimer hastalığı, Demans, Anti-Alzheimer bileşikler

Supporting Institution

Bu çalışma herhangi bir proje desteği olmadan Çukurova Üniversitesi Eczacılık Fakültesi bünyesinde gerçekleştirilmiştir.

Project Number

-

Thanks

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Alzheimer's Disease and Investigation of The Structure of Anti-Alzheimer Active Compounds

Abstract

Alzheimer's disease, the most common form of dementia, is a complex disease characterized by memory loss and other cognitive problems. Understanding the pathophysiology of Alzheimer's disease, which has an increasing prevalence, and investigating the structures of compounds that are effective in the treatment of this disease will help to develop new effective drug molecules. In this sense, it is of great importance to investigate the hypotheses that are effective on the disease, the structure of the active compounds, and their mechanisms of action. Recent studies have shown that focus on obtaining stronger compounds that can affect more than one of the hypotheses that are effective in the pathology of the disease. In this review study, the important hypotheses that play a role in the pathology of Alzheimer's disease and the structures of drug active compounds with proven anti-Alzheimer activity over these hypotheses are revealed.

Keywords

Dementia, Anti-Alzheimer compounds, Alzheimer

Project Number

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