Meme Kanseri Epigenetiğinde Biyobelirteçler: Çevresel Faktörlerin Etkisi

Ela Tuğrul Karataş; Muhammet Osman Karataş; Sibel Özden

doi:10.52794/hujpharm.1424049

Derleme

Biomarkers in Breast Cancer Epigenetics: Effect of Environmental Factors

Yıl 2024, Cilt: 44 Sayı: 2, 165 - 181, 01.06.2024

Ela Tuğrul Karataş Muhammet Osman Karataş Sibel Özden

https://doi.org/10.52794/hujpharm.1424049

Öz

Breast cancer is one of the leading causes of cancer-related deaths in women worldwide. Breast cancer has been associated with many risk factors like hormonal, genetics and lifestyle. However, emerging evidence highlights the significant role of environmental pollutants as a risk factor in breast cancer development. Especially some environmental pollutants can change gene expression through epigenetic mechanisms like DNA methylation, histone modification and micro-RNA changes. Epigenetic biomarkers from environmental pollutants may aid early diagnosis and prognosis in breast cancer. Nowadays, microRNAs are used as new biomarkers in breast cancer research. The ability to isolate from tissue, whole blood, serum and plasma and the ease of use as a biomarker has made miRNAs an important diagnostic tool. This review aims to shed light on the relationship between epigenetic biomarkers observed to change due to exposure to environmental pollutants and the risk of breast cancer. In this review the effects of environmental pollutants such as aryl hydrocarbon receptor agonists (dioxins, polychlorinated biphenyls, polycyclic aromatic hydrocarbons), phthalates, bisphenol A, and arsenic on epigenetic mechanisms is focused. It is thought that environmental exposures will decrease and personalized preventive strategies can be developed with the increase in epigenetic researches in breast cancer cases.

Anahtar Kelimeler

breast cancer, epigenetic mechanisms, environmental pollutants, DNA methylation, microRNAs

Kaynakça

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Meme Kanseri Epigenetiğinde Biyobelirteçler: Çevresel Faktörlerin Etkisi

Yıl 2024, Cilt: 44 Sayı: 2, 165 - 181, 01.06.2024

Ela Tuğrul Karataş Muhammet Osman Karataş Sibel Özden

https://doi.org/10.52794/hujpharm.1424049

Öz

Meme kanseri, dünya çapında kadınlardaki kansere bağlı ölümlerin başlıca nedenlerinden biridir. Meme kanseri hormonal, genetik, yaşam tarzı gibi birçok risk faktörü ile ilişkilendirilmiştir. Ancak günümüzde artan kanıtlar çevresel kirleticilere maruziyetin meme kanseri gelişiminde göz ardı edilemez bir risk faktörü olduğunu ortaya koymaktadır. Özellikle, bazı çevresel kirleticiler; DNA metilasyonu, histon modifikasyonu ve mikroRNA (miRNA)’ lardaki değişiklikler gibi epigenetik mekanizmalarla gen ifadesini değiştirebilir. Çevresel kirleticilere bağlı bu modifikasyonlarda saptanan epigenetik biyobelirteçlerin, meme kanserinde erken teşhis ve prognozun belirlenmesinde anahtar olabileceği düşünülmektedir. Günümüzde miRNA’lar meme kanseri araştırmalarında yeni biyobelirteçler olarak kullanılmaktadır. Doku, tam kan, serum ve plazmadan izole edilebilmesi ve biyobelirteç olarak kullanım kolaylığı miRNA’ları önemli bir teşhis aracı haline getirmiştir. Bu derlemenin çevresel kirleticilere maruziyet sonucu değişiklik gözlenen epigenetik biyobelirteçler ile meme kanseri riski arasındaki ilişkiye ışık tutacağı düşünülmektedir. Bu derlemede aril hidrokarbon reseptör agonistleri (dioksinler, poliklorlu bifeniller, polisiklik aromatik hidrokarbonlar), ftalatlar, bisfenol A ve arsenik gibi çevresel kirleticilerin epigenetik mekanizmalardaki etkisine odaklanılmıştır. Meme kanseri vakalarında epigenetik araştırmaların artması ile çevresel maruziyetlerin azalacağı ve kişiselleştirilmiş önleyici stratejilerin geliştirilebileceği düşünülmektedir.

Anahtar Kelimeler

meme kanseri, epigenetik mekanizmalar, çevresel kirleticiler, DNA metilasyonu, MikroRNA'lar

Kaynakça

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Toplam 100 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Farmasotik Toksikoloji
Bölüm	Review Articles
Yazarlar	Ela Tuğrul Karataş 0000-0001-7372-709X Muhammet Osman Karataş 0009-0002-1883-1438 Sibel Özden 0000-0002-1662-2504
Yayımlanma Tarihi	1 Haziran 2024
Gönderilme Tarihi	23 Ocak 2024
Kabul Tarihi	25 Mart 2024
Yayımlandığı Sayı	Yıl 2024 Cilt: 44 Sayı: 2

Kaynak Göster

Vancouver	Tuğrul Karataş E, Karataş MO, Özden S. Meme Kanseri Epigenetiğinde Biyobelirteçler: Çevresel Faktörlerin Etkisi. HUJPHARM. 2024;44(2):165-81.

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