The shortage of cadaveric organ donors continues to be a major problem for solid organtransplantation in Turkey as well as across the world. Due to this shortage, the use ofmarginal and expanded criteria donors has become a current issue to increase the numberof transplantation and to decrease waitlist mortality rates. The use of organs of marginaldonors with a history of or active central nervous system tumor has been one possiblesolution to increase the number of donors in organ transplantation. While this is a lifesaving practice for waitlist patients, it constitutes a risk of malignancy originating fromdonors. This is an important issue that should be discussed in the field of transplantationand ethics. This case study aims to discuss an ethical dilemma of liver transplantation froma donor with a history of central nervous system tumor to a patient in need of emergencyliver transplantation. It is considered that the decision-making process for the use ofmarginal donor grafts in solid organ transplantation should be managed in accordance withethical principles.