Primer Siliyer Diskinezili ve Sağlıklı Çocuklarda Aerobik Kapasitenin Karşılaştırılması

Abstract

Özet

Amaç: Nadir görülen otozomal resesif bir hastalık olan primer siliyer diskinezinin (PCD) egzersiz kapasitesine etkisi konusundaki bilgiler sınırlıdır. Bu çalışmada, PCD olan çocuklar ve sağlıklı bireylerde aerobik kapasitenin karşılaştırılması amaçlandı.

Gereç ve yöntemler: Çalışmaya PCD tanısı alan 15 çocuk (13.1±3.1 yıl) ve onlarla yaş ve cinsiyet açısından uyumlu 15 sağlıklı çocuk (13.3±3.2 yıl) alındı. Olgulara solunum fonksiyon testi ve modifiye mekik yürüme testi yapıldı. Egzersiz testi öncesinde ve sonrasında kalp hızı, kan basıncı, oksijen satürasyonu (SaO2) ve yorgunluk kaydedildi.

Sonuçlar: İki grubun fiziksel özellikleri birbirine benzerdi (p > 0.05). PCD’li olguların zorlu vital kapasite (FVC), birinci saniyedeki zorlu ekspirasyon volümü (FEV1), zorlu ekspiratuar akımın % 25-75’i , zorlu ekspiratuar akımın % 25’i (FEF%25), zorlu ekspiratuar akımın % 50’si (FEF%50), zorlu ekspiratuar akımın % 75’i (FEF%75), tepe akım hızı (PEF), mekik yürüme testi mesafesi ve egzersiz sırasındaki zirve egzersiz kalp hızı ve SaO2 değerleri sağlıklı olguların değerlerinden anlamlı olarak daha düşüktü (p < 0.05).

Tartışma: PCD’li olgularda erken dönemde solunum fonksiyonları ve maksimal aerobik kapasite olumsuz etkilenmektedir. PCD’li hastaların egzersiz eğitiminin, egzersiz kapasitesi ve havayolu temizlenmesine etkileri araştırılmalıdır

Keywords

• Primer siliyer diskinezi, Solunum fonksiyon testi, Egzersiz testi, Fiziksel aktivite, Çocuk

A Comparison of Aerobic Capacity Between Primary Ciliary Dyskinesia and Healthy Children

Abstract

Abstract:

Purpose: Information regarding the effects of primary ciliary dyskinesia (PCD), a rare usually autosomal recessive disease, on exercise capacity is limited. In this study, we aimed to compare aerobic capacity of children with PCD those with age-and sex matched healthy counterparts. 

Material and Methods: Fifteen patients with PCD (13.1±3.1 years) were participated, and 15 age- and sex-matched healthy children (13.3±3.2 years) were enrolled as controls. Patients underwent pulmonary function testing, a modified shuttle walk test was performed. Heart rate, blood pressure, oxygen saturation (Sa0₂), and fatigue were recorded before and after the exercise test.

Results: Physical characteristics of the two groups were similar (p>0.05). The PCD subjects’ forced vital capacity (FVC), forced expiratory volume in one second (FEV₁), forced expiratory flow between 25% and 75% (FEF_25-75%), forced expiratory flow at 25% (FEF_25%), forced expiratory flow at 50% (FEF_50%), forced expiratory flow at 75% (FEF_75%), peak expiratory flow (PEF),  shuttle walk test distance, and peak exercise heart rate, Sa0₂ values during exercise were significantly lower than those of healthy subjects (p<0.05).

Discussion: Pulmonary function and maximal aerobic capacity in patients with PCD are negatively affected at an early stage. The effects of exercise training, exercise capacity and airway clearance in PCD patients should be investigated.

Key Words: Primary ciliary dyskinesia; Pulmonary function test; Exercise test; Physical activity; Children.  

Keywords

• Primary ciliary dyskinesia; Pulmonary function test; Exercise test; Physical activity; Children

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