Harran Üniversitesi Tıp Fakültesi Dergisi

1304-9623 1309-4025

Harran Üniversitesi

10.35440/hutfd.1564881

Neurology and Neuromuscular Diseases

Nöroloji ve Nöromüsküler Hastalıklar

The Assessment of the Serum Asprosin and Adiponectin Levels in Ischemic Stro-ke Patients

İskemik İnme Hastalarında Serum Asprosin Ve Adiponektin Düzeylerinin Araştırılması

https://orcid.org/0000-0003-1662-5534

Şimşek

Fatma

ATATÜRK ÜNİVERSİTESİ, TIP FAKÜLTESİ

https://orcid.org/0000-0003-2706-7101

Eğilmez

Esra

ATATÜRK ÜNİVERSİTESİ

12 27 2024

21 3 540 546 10 10 2024 12 23 2024

2004

Harran Üniversitesi Tıp Fakültesi Dergisi

Background: The aim of this study was to investigate asprosin and adiponectin levels in the acute phase in patients with ischemic stroke and to investigate the relationship between asprosin and adiponectin and short-term prognosis.Materials and Methods: The study sample consisted of consecutive patients who were admitted with the diagnosis of acute ischemic stroke between March 2022 and June 2022 and control sub-jects with gender and age characteristics that match the patients. Serum asprosin and adiponectin levels were assessed and routine tests were carried out in both patient and control groups.Results: Serum asprosin level was significantly lower in the patient group than in the control group (p=0.012). Serum adiponectin level was lower than the control group but it was not statistically significant (p=0.126). There was a negative correlation between National Institutes of Health Stroke Score and serum asprosin level (r=-0.423, p=0.004), but not between serum adiponectin level (r=-0.234, p=0.122). There was a positive correlation between serum asprosin and adiponec-tin levels (r=0.667, p<0.001). There was no relationship between asprosin and adiponectin levels in the acute period and disability level in the second month (r=-0,267, p=0,077; r=-0,068, p=0,658).Conclusions: A decrease in asprosin levels is associated with an increased risk of ischemic stroke and acute stroke severity.Keywords: Asprosin, Adiponectin, Acute ischemic stroke

Amaç: İskemik inmeli hastalarda akut fazda asprosin ve adiponektin düzeylerinin ve asprosin ve adiponektinin birbirleriyle ve kısa dönem prognozla olan ilişkisinin araştırılması amaçlanmıştır.Materyal ve metod: Mart 2022-Haziran 2022 tarihleri arasında akut iskemik inme tanısı ile ardışık olarak gelen hastalar ve cinsiyet-yaş eşleştirilmiş kontrol grubu çalışmaya alındı. Her iki grupta da serum asprosin, adiponektin düzeyi ve rutin testler incelendi.Bulgular: İnme hastalarında serum asprosin düzeyi kontrol grubuna göre önemli ölçüde düşüktü (p=0,012). Serum adiponektin düzeyi kontrol grubuna göre düşük fakat istatistiksel olarak anlamlı değildi (p=0,126). Serum asprosin düzeyi ile Ulusal Sağlık Enstitüsü İnme Skoru arasında negatif yönde bir korelasyon vardı (r=-0,423, p=0,004). Serum adiponektin düzeyi ile Ulusal Sağlık Enstitü-sü İnme Skoru arasında anlamlı bir korelasyon yoktu (r=-0,234, p=0,122). Serum asprosin ve adi-ponektin düzeyleri arasında pozitif bir korelasyon vardı (r=0,667, p<0,001). Akut dönemdeki asprosin ve adiponektin düzeyi ile ikinci aydaki sakatlık düzeyi arasında bir ilişki yoktu (r=-0,267, p=0,077; r=-0,068, p=0,658).Sonuç: Asprosin düzeyindeki düşme artmış iskemik inme riski ve akut inme şiddeti ile ilişkilidir.

asprosin adiponektin akut iskemik inme

Asprosin Adiponectin Acute ischemic stroke

Atatürk Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

TAB-2022-10383

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