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Köpeklerde İdiyopatik Gastroenterit Hastalıklarının Histopatolojik Derecelendirilmesi

Yıl 2025, Cilt: 14 Sayı: 1, 18 - 24, 19.06.2025
https://doi.org/10.31196/huvfd.1588167

Öz

İdiyopatik gastroenteritis, mide ve bağırsaklarda lezyonlara neden olan bir hastalıktır. Patoloji Anabilim Dalı’na getirilen ishal, kusma, kilo kaybı ve diğer gastrointestinal bulguları gözlenen farklı yaş, cinsiyet ve ırktan yirmi köpeğin nekropsisi yapıldı. Patolojik incelemeler için midenin kardia, fundus, antrum ve pilorus kısımlarından ve bağırsakların duodenum, jejunum, ileum, sekum, kolon ile mezenterik lenf düğümlerinden örnekler alındı. Bunlar hematoksilen ve eozin (H&E) ile boyandı. Histopatolojik inceleme sonucunda eozinofilik enteritis (n: 4), eozinofilik enteritis (n: 4), lenfositik-plazmasitik gastroenteritis (n: 3), eozinofilik gastroenteritis (n: 4) ve lenfositik-plazmasitik enteritis (n: 5) ile lenfositik-plazmasitik gastritis tanısı konuldu. Bu nedenle idiyopatik gastroenteritis hastalığının Türkiye'de yaygın olduğu düşünülmektedir. Ayrıca hastalığın insidansı hakkında güncel veriler sağlanmıştır.

Proje Numarası

This study was supported by grants from TÜBİTAK BİDEP 2209-A (Project number 919B01221449).

Kaynakça

  • Allenspach KA, Mochel JP, Du Y, Priestnall SL, Moore F, Slayter M, Rodrigues A, Ackermann M, Krockenberger M, Mansell J, WSAVA GI Standardization Working Group, Luckschander N, Chong W, Suchodolski J, Berghoff N, Jergens AE, 2019: Correlating gastrointestinal histopathologic changes to clinical disease activity in dogs with idiopathic inflammatory bowel disease. Vet Pathol, 56 (3), 435-443.
  • Bhavani MS, Kavitha S, Vairamuthu S, Vijayarani K, Bhat AA, 2023: Clinical signs, activity indices and prognostic indicators in dogs with idiopathic inflammatory bowel Disease. Indian J Anim Res, 57 (11), 1544-1549.
  • Cerquetella M, Spaterna A, Laus F, Tesei B, Rossi G, Antonelli E, Villanacci V, Bassotti G, 2010: Inflammatory bowel disease in dogs: differences and similarities with humans. World J Gastroenterol, 16 (9), 1050.
  • Day MJ, Bilzer T, Mansell J, Wilcock B, Hall EJ, Jergens A, Minami T, Willard M, Washabau R, 2008: Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: A report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group. J Comp Pathol, 138, 1-43.
  • Dye TL, Diehl KJ, Wheeler SL, Westfall DS, 2013: Randomized, controlled trial of budesonide and prednisone for the treatment of idiopathic inflammatory bowel disease in dogs. J Vet Intern Med, 27 (6), 1385-1391.
  • Farray D, Rodríguez F, Muñoz-Aznar Y, Ravelo-García AG, Jaber JR, 2020: Study of correlations between clinical signs and morphological features identified in dogs affected with inflammatory bowel disease. Mac Vet Rev, 43 (1), 13-22.
  • Fonseca-Alves CE, Corrêa AG, Elias F, 2012: Eosinophilic gastroenteritis in basset hound dog. Open J Anim Sci, 2(2), 110-112.
  • German AJ, Hall EJ, Day MJ, 1999: Analysis of leucocyte subsets in the canine intestine. J Comp Pathol, 120(2): 129-145.
  • Hall JE, Simpson JW, Williams DA, 2005: BSAVA manual of canine and feline gastroenterology (No. Ed. 2). British Small Animal Veterinary Association.
  • Jergens AE, Schreiner CA, Frank DE, Niyo Y, Ahrens FE, Eckersall PD, Benson TJ, Evans R, 2003: A scoring index for disease activity in canine inflammatory bowel disease. J Vet Intern Med, 17 (3), 291-297.
  • Jergens AE, Simpson KW, 2012: Inflammatory bowel disease in veterinary medicine. Front Biosci (Elite Ed), 4 (4), 1404-1419.
  • Kanat O, Ortatatli M, 2011: Pathological and microbiological ınvestigations on alimentary system lesions of dogs: oral, oesophagus and stomach. J Anim Vet Adv, 10 (22), 2892-2901.
  • Kanat Ö, Ortatatlı, M, 2022: Detection of multiple etiologies and comparison and investigation of pathological changes in small and large intestine lesions of dogs. Eurasian J Vet Sci, 38, 4, 214-224.
  • Kathrani A, Werling D, Allenspach K, 2011: Canine breeds at high risk of developing inflammatory bowel disease in the south‐eastern UK. Vet Rec, 169 (24), 635-635.
  • Lee JH, Kim HS, Lee D, Yun T, Koo Y, Chae Y, Kang JH, Kang BT, Yang MP, Kim H, 2021: Clinical signs, duodenal histopathological grades, and serum high‐mobility group box 1 concentrations in dogs with inflammatory bowel disease. J Vet Intern Med, 35 (5), 2205-2214.
  • Lyles SE, Panciera DL, Saunders GK, Leib MS, 2009: Idiopathic eosinophilic masses of the gastrointestinal tract in dogs. J Vet Intern Med, 23 (4), 818-823.
  • Marchetti V, Benetti C, Citi S, Taccini V, 2005: Paraneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma. Vet Clin Pathol, 34, 259-263.
  • McCann TM, Ridyard AE, Else RW, Simpson JW, 2007: Evaluation of disease activity markers in dogs with idiopathic inflammatory bowel disease. J Small Anim Pract, 48 (11), 620-625.
  • McTavish S, 2002: Eosinophilic gastroenteritis in a dog. Can Vet J, 43 (6), 463.
  • Minnat TR, Al-Bassam LS, Rasheed YM, 2017: Eosinophilic gastro-enteritis in a German shepherd dog: Clinical, Haematological and Biochemical study. Journal of Kerbala for Agricultural Sciences, 4 (5), 191-201.
  • Neiger R, 2008: Diseases of the stomach. In: J.M. Steiner (Ed.), Small Animal Gastroenterology. (pp. 158-179). Germany: Schlutersche.
  • Niina A, Kibe R, Suzuki R, Yuchi Y, Teshima T, Matsumoto H, Kataoka Y, Koyama H, 2021: Fecal microbiota transplantation as a new treatment for canine inflammatory bowel disease. Biosci Microbiota Food Health, 40 (2), 98-104.
  • Ozaki K, Yamagami T, Nomura K, Narama I, 2006: T-cell lymphoma with eosinophilic infiltration involving the intestinal tract in 11 dogs. Vet Pathol, 43, 339-344.
  • Rousseau M, 2005: Severe lymphocytic-plasmacytic and atrophic gastritis, as well as, predominantly eosinophilic, severe enteritis, in a 19-month-old Labrador retriever. Can Vet J, 46 (3), 264.
  • Rychlik A, Nieradka R, Kander M, Depta A, Nowicki M, Sarti K, 2007: Usefulness of endoscopic examination for the diagnosis of inflammatory bowel disease in the dog. A case report. Pol J Vet Sci, 10 (2), 113-118.
  • Sattasathuchana P, Steiner JM, 2014: Canine eosinophilic gastrointestinal disorders. Anim Health Res Rev, 15 (1), 76-86.
  • Simpson KW, 2010: Diseases of the stomach. In: S.J. Ettinger, E.C. Feldman (Eds.), Textbook of Veterinary Internal Medicine. (pp. 1504-1526). Canada: Saunders-Elsevier.
  • Tomiyasu H, Fujino Y, Ugai J, Goto-Koshino Y, Ide T, Takahashi M, Ohno K, Uchida K, Nakayam H, Tsujimoto H, 2010: Eosinophilia and eosinophilic infiltration into splenic B-cell high-grade lymphoma in a dog. J Vet Med Sci, 72 (10), 1367-1370.

Histopathological Grading of Idiopathic Gastroenteritis Diseases in Dogs

Yıl 2025, Cilt: 14 Sayı: 1, 18 - 24, 19.06.2025
https://doi.org/10.31196/huvfd.1588167

Öz

Idiopathic gastroenteritis is a disease that causes lesions in the stomach and intestines. Twenty dogs of different ages, genders, and breeds showing diarrhea, vomiting, weight loss, and other gastrointestinal findings brought to the Department of Pathology were performed necropsy. For pathological examinations, samples were taken from the cardia, fundus, antrum, and pylorus parts of the stomach and the duodenum, jejunum, ileum, cecum, colon, and mesenteric lymph nodes of the intestines. They were stained with hematoxylin and eosin (H&E). It was diagnosed as lymphocytic-plasmacytic gastritis with eosinophilic enteritis (n: 4), eosinophilic enteritis (n: 4), lymphocytic-plasmacytic gastroenteritis (n: 3), eosinophilic gastroenteritis (n: 4) and lymphocytic-plasmacytic enteritis (n: 5) histopathologically. Thus, it was determined that idiopathic gastroenteritis disease was thought to be common in Turkey and current data on incidence of the disease were provided.

Proje Numarası

This study was supported by grants from TÜBİTAK BİDEP 2209-A (Project number 919B01221449).

Kaynakça

  • Allenspach KA, Mochel JP, Du Y, Priestnall SL, Moore F, Slayter M, Rodrigues A, Ackermann M, Krockenberger M, Mansell J, WSAVA GI Standardization Working Group, Luckschander N, Chong W, Suchodolski J, Berghoff N, Jergens AE, 2019: Correlating gastrointestinal histopathologic changes to clinical disease activity in dogs with idiopathic inflammatory bowel disease. Vet Pathol, 56 (3), 435-443.
  • Bhavani MS, Kavitha S, Vairamuthu S, Vijayarani K, Bhat AA, 2023: Clinical signs, activity indices and prognostic indicators in dogs with idiopathic inflammatory bowel Disease. Indian J Anim Res, 57 (11), 1544-1549.
  • Cerquetella M, Spaterna A, Laus F, Tesei B, Rossi G, Antonelli E, Villanacci V, Bassotti G, 2010: Inflammatory bowel disease in dogs: differences and similarities with humans. World J Gastroenterol, 16 (9), 1050.
  • Day MJ, Bilzer T, Mansell J, Wilcock B, Hall EJ, Jergens A, Minami T, Willard M, Washabau R, 2008: Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: A report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group. J Comp Pathol, 138, 1-43.
  • Dye TL, Diehl KJ, Wheeler SL, Westfall DS, 2013: Randomized, controlled trial of budesonide and prednisone for the treatment of idiopathic inflammatory bowel disease in dogs. J Vet Intern Med, 27 (6), 1385-1391.
  • Farray D, Rodríguez F, Muñoz-Aznar Y, Ravelo-García AG, Jaber JR, 2020: Study of correlations between clinical signs and morphological features identified in dogs affected with inflammatory bowel disease. Mac Vet Rev, 43 (1), 13-22.
  • Fonseca-Alves CE, Corrêa AG, Elias F, 2012: Eosinophilic gastroenteritis in basset hound dog. Open J Anim Sci, 2(2), 110-112.
  • German AJ, Hall EJ, Day MJ, 1999: Analysis of leucocyte subsets in the canine intestine. J Comp Pathol, 120(2): 129-145.
  • Hall JE, Simpson JW, Williams DA, 2005: BSAVA manual of canine and feline gastroenterology (No. Ed. 2). British Small Animal Veterinary Association.
  • Jergens AE, Schreiner CA, Frank DE, Niyo Y, Ahrens FE, Eckersall PD, Benson TJ, Evans R, 2003: A scoring index for disease activity in canine inflammatory bowel disease. J Vet Intern Med, 17 (3), 291-297.
  • Jergens AE, Simpson KW, 2012: Inflammatory bowel disease in veterinary medicine. Front Biosci (Elite Ed), 4 (4), 1404-1419.
  • Kanat O, Ortatatli M, 2011: Pathological and microbiological ınvestigations on alimentary system lesions of dogs: oral, oesophagus and stomach. J Anim Vet Adv, 10 (22), 2892-2901.
  • Kanat Ö, Ortatatlı, M, 2022: Detection of multiple etiologies and comparison and investigation of pathological changes in small and large intestine lesions of dogs. Eurasian J Vet Sci, 38, 4, 214-224.
  • Kathrani A, Werling D, Allenspach K, 2011: Canine breeds at high risk of developing inflammatory bowel disease in the south‐eastern UK. Vet Rec, 169 (24), 635-635.
  • Lee JH, Kim HS, Lee D, Yun T, Koo Y, Chae Y, Kang JH, Kang BT, Yang MP, Kim H, 2021: Clinical signs, duodenal histopathological grades, and serum high‐mobility group box 1 concentrations in dogs with inflammatory bowel disease. J Vet Intern Med, 35 (5), 2205-2214.
  • Lyles SE, Panciera DL, Saunders GK, Leib MS, 2009: Idiopathic eosinophilic masses of the gastrointestinal tract in dogs. J Vet Intern Med, 23 (4), 818-823.
  • Marchetti V, Benetti C, Citi S, Taccini V, 2005: Paraneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma. Vet Clin Pathol, 34, 259-263.
  • McCann TM, Ridyard AE, Else RW, Simpson JW, 2007: Evaluation of disease activity markers in dogs with idiopathic inflammatory bowel disease. J Small Anim Pract, 48 (11), 620-625.
  • McTavish S, 2002: Eosinophilic gastroenteritis in a dog. Can Vet J, 43 (6), 463.
  • Minnat TR, Al-Bassam LS, Rasheed YM, 2017: Eosinophilic gastro-enteritis in a German shepherd dog: Clinical, Haematological and Biochemical study. Journal of Kerbala for Agricultural Sciences, 4 (5), 191-201.
  • Neiger R, 2008: Diseases of the stomach. In: J.M. Steiner (Ed.), Small Animal Gastroenterology. (pp. 158-179). Germany: Schlutersche.
  • Niina A, Kibe R, Suzuki R, Yuchi Y, Teshima T, Matsumoto H, Kataoka Y, Koyama H, 2021: Fecal microbiota transplantation as a new treatment for canine inflammatory bowel disease. Biosci Microbiota Food Health, 40 (2), 98-104.
  • Ozaki K, Yamagami T, Nomura K, Narama I, 2006: T-cell lymphoma with eosinophilic infiltration involving the intestinal tract in 11 dogs. Vet Pathol, 43, 339-344.
  • Rousseau M, 2005: Severe lymphocytic-plasmacytic and atrophic gastritis, as well as, predominantly eosinophilic, severe enteritis, in a 19-month-old Labrador retriever. Can Vet J, 46 (3), 264.
  • Rychlik A, Nieradka R, Kander M, Depta A, Nowicki M, Sarti K, 2007: Usefulness of endoscopic examination for the diagnosis of inflammatory bowel disease in the dog. A case report. Pol J Vet Sci, 10 (2), 113-118.
  • Sattasathuchana P, Steiner JM, 2014: Canine eosinophilic gastrointestinal disorders. Anim Health Res Rev, 15 (1), 76-86.
  • Simpson KW, 2010: Diseases of the stomach. In: S.J. Ettinger, E.C. Feldman (Eds.), Textbook of Veterinary Internal Medicine. (pp. 1504-1526). Canada: Saunders-Elsevier.
  • Tomiyasu H, Fujino Y, Ugai J, Goto-Koshino Y, Ide T, Takahashi M, Ohno K, Uchida K, Nakayam H, Tsujimoto H, 2010: Eosinophilia and eosinophilic infiltration into splenic B-cell high-grade lymphoma in a dog. J Vet Med Sci, 72 (10), 1367-1370.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Patoloji
Bölüm Araştıma
Yazarlar

Canan Çakmak Bu kişi benim 0009-0007-3570-5181

Arda Selin Tunç 0000-0002-4813-7626

Proje Numarası This study was supported by grants from TÜBİTAK BİDEP 2209-A (Project number 919B01221449).
Yayımlanma Tarihi 19 Haziran 2025
Gönderilme Tarihi 20 Kasım 2024
Kabul Tarihi 29 Ocak 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 14 Sayı: 1

Kaynak Göster

APA Çakmak, C., & Tunç, A. S. (2025). Histopathological Grading of Idiopathic Gastroenteritis Diseases in Dogs. Harran University Journal of the Faculty of Veterinary Medicine, 14(1), 18-24. https://doi.org/10.31196/huvfd.1588167
AMA Çakmak C, Tunç AS. Histopathological Grading of Idiopathic Gastroenteritis Diseases in Dogs. Harran Univ Vet Fak Derg. Haziran 2025;14(1):18-24. doi:10.31196/huvfd.1588167
Chicago Çakmak, Canan, ve Arda Selin Tunç. “Histopathological Grading of Idiopathic Gastroenteritis Diseases in Dogs”. Harran University Journal of the Faculty of Veterinary Medicine 14, sy. 1 (Haziran 2025): 18-24. https://doi.org/10.31196/huvfd.1588167.
EndNote Çakmak C, Tunç AS (01 Haziran 2025) Histopathological Grading of Idiopathic Gastroenteritis Diseases in Dogs. Harran University Journal of the Faculty of Veterinary Medicine 14 1 18–24.
IEEE C. Çakmak ve A. S. Tunç, “Histopathological Grading of Idiopathic Gastroenteritis Diseases in Dogs”, Harran Univ Vet Fak Derg, c. 14, sy. 1, ss. 18–24, 2025, doi: 10.31196/huvfd.1588167.
ISNAD Çakmak, Canan - Tunç, Arda Selin. “Histopathological Grading of Idiopathic Gastroenteritis Diseases in Dogs”. Harran University Journal of the Faculty of Veterinary Medicine 14/1 (Haziran2025), 18-24. https://doi.org/10.31196/huvfd.1588167.
JAMA Çakmak C, Tunç AS. Histopathological Grading of Idiopathic Gastroenteritis Diseases in Dogs. Harran Univ Vet Fak Derg. 2025;14:18–24.
MLA Çakmak, Canan ve Arda Selin Tunç. “Histopathological Grading of Idiopathic Gastroenteritis Diseases in Dogs”. Harran University Journal of the Faculty of Veterinary Medicine, c. 14, sy. 1, 2025, ss. 18-24, doi:10.31196/huvfd.1588167.
Vancouver Çakmak C, Tunç AS. Histopathological Grading of Idiopathic Gastroenteritis Diseases in Dogs. Harran Univ Vet Fak Derg. 2025;14(1):18-24.