Sex and Age-related Occurrences of Hypotension and Pre-diabetes

Abstract

Objective: This study was aimed at assessing the occurrence of hypotension and pre-diabetes among various sex and age range of individuals. Method: Blood pressure (mmHg) and blood glucose (mg/dl) were determined; Data of subjects classified as hypotension (BP < 90/60 mmHg) and/or pre-diabetes (FBS; 100 – 125 mg/dl, RBS; 140-200mg/dl) were used for the study. SPSS (v25) was used for data analysis and the occurrence of hypotension and/or pre-diabetes among various sexes (male, female) and age intervals (15>25 years, 25>35 years, 35>45 years, 45>55years) of individuals was ascertained. Results: Data of sixty-two (62) subjects was purposively selected for the study; 61.3% were females while 38.7% were males. Greater proportion (72.6%) had age 15>25, 17.7% had age 25>35, 3.2% had age 35>45 and 6.5% had age 45>55. About 28 (45.2%) had hypotension only, 27 (43.5%) had pre-diabetes only; while 7 (11.3%) had coexistence of hypotension and pre-diabetes. There was equivalent prevalence of hypotension among the females and males; females had higher (66.7%) occurrence of pre-diabetes than males (33.3%). There was also higher prevalence of coexistence of hypotension and pre-diabetes in females (85.7%) than males (14.3%) at P=0.17, X2=3.59. Individuals with age 15>25 had higher prevalence of hypotension (82.1%), pre-diabetes (63.0%) as well as coexistence of hypotension and pre-diabetes (71.4%) when compared to age 25>35, 35>45 and 45>55 years at P=0.46, X2=5.67. Conclusion: despites the differences in occurrence of hypotension and pre-diabetes among various sexes and age range, there was no statistically significant association between the studied pathophysiological conditions and sex or age at P<0.05; which has demonstrated that hypotension and pre-diabetes can occur to any sex at any age.

Keywords

• Blood pressure
• Blood sugar
• Hypotension
• pre-diabetes

Project Number

N/A

Ethical Statement

study was performed in accordance of basic principles of ethics, subjects consent was obtained verbally and confidentiality was maintained

References

1. National High Blood Pressure Education Program. (2004). The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. https://www.ncbi.nlm.nih.gov/books/NBK9633/table/A32/
2. Sharma, S., Hashmi, M. F., Bhattacharya, P. T. (2022). Hypotension. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK499961/
3. Nitzan, M. (2011). Automatic noninvasive measurement of arterial blood pressure. IEEE instrumentation & measurement magazine, 14(1), 32-37.
4. Dhillon, A. K., Rabinstein, A. A., & Wijdicks, E. F. (2010). Coma from worsening spontaneous intracranial hypotension after subdural hematoma evacuation. Neurocritical care, 12, 390-394.
5. Okerulu, A. L., Onwuka, O. M., & Ajuzie, G. C. (2023). Hepatic Enzymatic Activities of Di-Herbal Aqueous Extract of Ocimum gratissimum and Gongronema latifolium on Liver Dysfunction in Experimental Hyperglycemic Rats. Journal of International Research in Medical and Pharmaceutical Sciences, 18(2), 13-22.
6. Onwuka, O. M., Nwosu, N. C., Okerulu, A. L. & Ajuzie, G. C., (2023). Aspects of morphogenetic traits associated with physiological coefficients related to incidence of obesity, hypertension, and diabetes mellitus. Innovare Journal of Life Sciences. 11(1), 7–10. https://doi.org/10.22159/ijls.2023.v11i1.48394.
7. Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016). Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus. Endocrine reviews, 37(3), 278-316.
8. Vetvik, K. G., & MacGregor, E. A. (2017). Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. The Lancet Neurology, 16(1), 76-87.

9. Ajuzie, G. C., Onwuka, O. M. & Okerulu, A. L., (2023). Low vision and influencing factors of visual acuity among students. Human Biology Review, 12 (3), 187-194.
10. Ajuzie, G. C., Martin, E. O., & Onwuka, O. M. (2023). A Community-Based Study of Behavioural Perception of Psychoactive Drug Abuse in Southern Nigeria. Annals of Health Research, 9(1), 23-29.
11. Onwuka, O. M. (2023). Prospective loss of human reproductive functionality: An implication of artificial medical intelligence, its invention of sex robot machines and assisted reproductive technology. Advance Journal of Current Research, 8(2).
12. Colafella, K. M. M., & Denton, K. M. (2018). Sex-specific differences in hypertension and associated cardiovascular disease. Nature Reviews Nephrology, 14(3), 185-201.
13. Onwuka, O. M., Okerulu, A. L., & Nwosu, N. C. (2022). Melatonin Involvement in Syncope Associated with Sleep Disturbance: A Case Report. International Journal of Medical and Pharmaceutical Case Reports, 15(4), 6-9.
14. Utami, P. R., Handayani, R. P., & Sheila, S. (2020). Evaluation of variations in the response of hypertensive patients in the outpatient installation of the UPT Puskesmas, Babat Lamongan District. Farmasains: Jurnal Farmasi dan Ilmu Kesehatan, 5(1), 35-39.
15. San Millán, J. L., Cortón, M., Villuendas, G., Sancho, J., Peral, B., & Escobar-Morreale, H. F. (2004). Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity. The Journal of Clinical Endocrinology & Metabolism, 89(6), 2640-2646.
16. Herath, H., Herath, R., & Wickremasinghe, R. (2017). Gestational diabetes mellitus and risk of type 2 diabetes 10 years after the index pregnancy in Sri Lankan women—A community based retrospective cohort study. PloS one, 12(6), e0179647.
17. Chesnut, R. M., Marshall, S. B., Piek, J., Blunt, B. A., Klauber, M. R., & Marshall, L. F. (1993). Early and late systemic hypotension as a frequent and fundamental source of cerebral ischemia following severe brain injury in the Traumatic Coma Data Bank. In Monitoring of cerebral blood flow and metabolism in intensive care (pp. 121-125). Vienna: Springer Vienna.
18. Finucane, C., O’Connell, M. D., Fan, C. W., Savva, G. M., Soraghan, C. J., Nolan, H., ... & Kenny, R. A. (2014). Age-related normative changes in phasic orthostatic blood pressure in a large population study: findings from The Irish Longitudinal Study on Ageing (TILDA). Circulation, 130(20), 1780-1789.
19. Preston, J., & Biddell, B. (2021). The physiology of ageing and how these changes affect older people. Medicine, 49(1), 1-5.
20. Tura, A., Pacini, G., Moro, E., Vrbíková, J., Bendlová, B., & Kautzky-Willer, A. (2018). Sex-and age-related differences of metabolic parameters in impaired glucose metabolism and type-2 diabetes compared to normal glucose tolerance. Diabetes Research and Clinical Practice, 146, 67-75.
21. Lohse, Z., Knorr, S., Bytoft, B., Clausen, T. D., Jensen, R. B., Oturai, P., ... & Jensen, D. M. (2018). Differential effects of age and sex on insulin sensitivity and body composition in adolescent offspring of women with type 1 diabetes: results from the EPICOM study. Diabetologia, 61, 210-219.