Yıl 2015, Cilt 7 , Sayı 1, Sayfalar 1 - 14 2015-06-01

The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism

Hasan M. DURGUN [1] , Cafer GULOGLU [2] , Mustafa ALDEMİR [3] , Alpaslan K. TUZCU [4] , Mehmet USTUNDAG [5]


Background: The incidence of cerebrovascular disease in diabetic patients is 6 times higher than nondiabetic patients. Approximately 85% of these patients die because of the cardiovascular diseases. DM is an independent risk factor for cardiovascular diseases, and this risk increased much with accompanying dyslipidemia. In diabetic patients, increased triglyceride and decreased HDL cholesterol accelerate atherosclerosis. In stroke patients, increased plasma Pro-BNP levels are associated directly with stroke severity and mortality. Method: Following the approval of Dicle University Medical Faculty Ethics Committee, the randomly selected patients admitted to the emergency department with the following thromboembolic complaints were investigated prospectively for 6 months study period. The patients were classified into 4 groups. Group 1: type 2 Diabetes Mellitus (DM) without thromboembolic complications; group 2: type 2 DM with thromboembolic complications; group 3: thromboembolism without DM; group 4: healthy volunteers. The coagulation factors, lipid profiles and pro-BNP levels were measured in all patients. Results: Systolic tension arterial (STA) and diastolic tension arterial (DTA) levels were significantly higher in group 2 as compared to group 1 and control groups (p < 0,05). Among groups, there were statistically significant differences in glucose, urea, creatinine, fibrinogen, factor 7, factor 8, pro-BNP, triglyceride, HDL, VLDL levels (p < 0,05). Conclusion: DM is a factor that increases STA and DTA levels. In type 2 diabetes, fibrinogen and coagulation factors such as factor 7 and factor 8 increase, anticoagulant factors decrease, HDL cholesterol levels decrease, triglyceride levels and VLDL cholesterol levels increase and pro-BNP levels increase. As a result, the risk of arteriosclerosis and thromboembolism associated with ischemic stroke, peripheral and coronary artery disease and mortality increase
Type 2 diabetes mellitus, stroke, coronary artery disease, thromboembolism
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Diğer ID JA34ZG43JB
Bölüm Araştırma
Yazarlar

Yazar: Hasan M. DURGUN

Yazar: Cafer GULOGLU

Yazar: Mustafa ALDEMİR

Yazar: Alpaslan K. TUZCU

Yazar: Mehmet USTUNDAG

Tarihler

Yayımlanma Tarihi : 1 Haziran 2015

Bibtex @ { iamr272714, journal = {International Archives of Medical Research}, issn = {2146-6033}, address = {Dicle Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD, 21280, Diyarbakır-Türkiye}, publisher = {Veysi AKPOLAT}, year = {2015}, volume = {7}, pages = {1 - 14}, doi = {}, title = {The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism}, key = {cite}, author = {DURGUN, Hasan M. and GULOGLU, Cafer and ALDEMİR, Mustafa and TUZCU, Alpaslan K. and USTUNDAG, Mehmet} }
APA DURGUN, H , GULOGLU, C , ALDEMİR, M , TUZCU, A , USTUNDAG, M . (2015). The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism. International Archives of Medical Research , 7 (1) , 1-14 . Retrieved from https://dergipark.org.tr/tr/pub/iamr/issue/25887/272714
MLA DURGUN, H , GULOGLU, C , ALDEMİR, M , TUZCU, A , USTUNDAG, M . "The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism". International Archives of Medical Research 7 (2015 ): 1-14 <https://dergipark.org.tr/tr/pub/iamr/issue/25887/272714>
Chicago DURGUN, H , GULOGLU, C , ALDEMİR, M , TUZCU, A , USTUNDAG, M . "The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism". International Archives of Medical Research 7 (2015 ): 1-14
RIS TY - JOUR T1 - The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism AU - Hasan M. DURGUN , Cafer GULOGLU , Mustafa ALDEMİR , Alpaslan K. TUZCU , Mehmet USTUNDAG Y1 - 2015 PY - 2015 N1 - DO - T2 - International Archives of Medical Research JF - Journal JO - JOR SP - 1 EP - 14 VL - 7 IS - 1 SN - 2146-6033- M3 - UR - Y2 - 2020 ER -
EndNote %0 International Archives of Medical Research The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism %A Hasan M. DURGUN , Cafer GULOGLU , Mustafa ALDEMİR , Alpaslan K. TUZCU , Mehmet USTUNDAG %T The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism %D 2015 %J International Archives of Medical Research %P 2146-6033- %V 7 %N 1 %R %U
ISNAD DURGUN, Hasan M. , GULOGLU, Cafer , ALDEMİR, Mustafa , TUZCU, Alpaslan K. , USTUNDAG, Mehmet . "The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism". International Archives of Medical Research 7 / 1 (Haziran 2015): 1-14 .
AMA DURGUN H , GULOGLU C , ALDEMİR M , TUZCU A , USTUNDAG M . The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism. IAMR. 2015; 7(1): 1-14.
Vancouver DURGUN H , GULOGLU C , ALDEMİR M , TUZCU A , USTUNDAG M . The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism. International Archives of Medical Research. 2015; 7(1): 14-1.