The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism

Year 2015, Volume: 7 Issue: 1, 1 - 14, 01.06.2015

Hasan M. Durgun Cafer Guloglu Mustafa Aldemir Alpaslan K. Tuzcu Mehmet Ustundag

Abstract

Background: The incidence of cerebrovascular disease in diabetic patients is 6 times higher than
nondiabetic patients. Approximately 85% of these patients die because of the cardiovascular diseases. DM is
an independent risk factor for cardiovascular diseases, and this risk increased much with accompanying
dyslipidemia. In diabetic patients, increased triglyceride and decreased HDL cholesterol accelerate
atherosclerosis. In stroke patients, increased plasma Pro-BNP levels are associated directly with stroke
severity and mortality.
Method: Following the approval of Dicle University Medical Faculty Ethics Committee, the randomly
selected patients admitted to the emergency department with the following thromboembolic complaints were
investigated prospectively for 6 months study period. The patients were classified into 4 groups. Group 1:
type 2 Diabetes Mellitus (DM) without thromboembolic complications; group 2: type 2 DM with
thromboembolic complications; group 3: thromboembolism without DM; group 4: healthy volunteers. The
coagulation factors, lipid profiles and pro-BNP levels were measured in all patients.
Results: Systolic tension arterial (STA) and diastolic tension arterial (DTA) levels were significantly higher
in group 2 as compared to group 1 and control groups (p < 0,05). Among groups, there were statistically
significant differences in glucose, urea, creatinine, fibrinogen, factor 7, factor 8, pro-BNP, triglyceride,
HDL, VLDL levels (p < 0,05).
Conclusion: DM is a factor that increases STA and DTA levels. In type 2 diabetes, fibrinogen and
coagulation factors such as factor 7 and factor 8 increase, anticoagulant factors decrease, HDL cholesterol
levels decrease, triglyceride levels and VLDL cholesterol levels increase and pro-BNP levels increase. As a
result, the risk of arteriosclerosis and thromboembolism associated with ischemic stroke, peripheral and
coronary artery disease and mortality increase

Keywords

Type 2 diabetes mellitus, stroke, coronary artery disease, thromboembolism

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