Comparative Investigation of The Effects of Platelet-Rich Plasma in Sinus Lifting

Yıl 2015, Cilt: 7 Sayı: 2, 1 - 12, 01.12.2015

Hilal Alan Gülten Kavak Yusuf Nergiz Selcuk Tunik İzzet Yavuz

Öz

Background: In this study, we aimed to evaluate the produced bone’s quality, quantity, volume and the period of the healing process clinically, radiologically, histologically and histomorphologically after a sinus lifting operation using a natural mineralized bone graft with or without Platelet Rich Plasma (PRP). Material and methods: 22 sinus elevation operations under local anesthesia performed on 16 patients with no systemic illnesses which may affect healing. Before the operations, orthopantomograph and conical beam 3D dental tomographies of all patients were taken. Ten of the sinus lifting operations were performed by using mineralized hydroxyapatite and PRP mixtures produced from the patients’ own blood samples (Group 1); the other 12 sinus lifting operations were performed by using natural mineralized hydroxyapatite (Group 2). Orthopantomograph and computerized tomographies of the first group of patients were taken following a four-month healing period and for the second group following an eight-month healing period. After that, a bone biopsy was taken using trephine burs and dental implants were installed. At the end of the four-month healing period, biopsy samples were taken from two patients in the second group. The samples were evaluated histomorphologically. Results: In the histomorphological evaluation, core biopsies taken from the first group after the fourth month revealed greater bone formation, osteoid tissue and lamellar matrix. But no significant differences were statistically observed between the two groups. Conclusion: Although there were no significant differences in amount of bone healing, the bone healing of the first group was faster than that of the second group

Anahtar Kelimeler

Platelet-Rich Plasma, Maxillary Sinus, Guided tissue regeneration, Bone regeneration

Kaynakça

• Fürst G, Gruber R, Tangl S, Zechner W, Haas R, Mailath G, Sanroman F, Watzek G. Sinus grafting with autogenous platelet-rich plasma and bovine hydroxyapatite. Clin Oral Implants Res 2003; 14: 500-8.
• Jensen OT, editor. The Sinus Bone Graft. Chicago: Quintessence Publishing: 1999.
• Tatum HJr. Maxillary and sinus implant reconstructions. Dent Clin North Am 1986; 30: 207-29. 4.Wiltfang J, Schlegel KA, Schultze-Mosgau S, Nkenke E, Zimmermann R Kessler P. Sinus floor augmentation with β-tricalciumphosphate (β-TCP): does platelet-rich plasma promote its osseous integration and degradation? Clin Oral Implants Res 2003; 14: 213-8.
• Van Den Bergh JP, Bruggenkate CM, Disch FJ, Tuinzing DB. Anatomical aspects of sinus floor elevations. Clin Oral Implants Res 2000; 11: 256-65.
• Scarano A, Degidi M, Iezzi G, Pecora G, Piattelli M, Orsini G, Caputi S, Perrotti V, Mangano C, Piattelli A. Maxillary sinus augmentation with different biomaterials: a comparative histologic and histomorphometric study in man. Implant Dentistry 2006; 15: 197-207.
• Choukroun J, Diss A, Simonpieri A. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101: 299-03.
• Dugrillon A, Eichler H, Kern S, Klüter H. Autologous concentrated platelet-rich plasma (cPRP) for local application in bone regeneration. Int J Oral Maxillofac Surg 2002; 31: 615-9.
• Tözüm TF, Demiralp B. Platelet-Rich Plasma: A Promising Innovation in Dentistry. J Can Dent Assoc 2003; 69: 664.
• Grageda E. Platelet-rich plasma and bone graft materials: a review and a standardized research protocol. Implant Dentistry 2004; 13: 301-9.
• Jakse N, Tangl S, Gilli R, Berghold A, Lorenzoni M, Eskici A, Haas R, Pertl C. Influence of PRP on autogenous sinus grafts. Clin Oral Implants Res 2003; 14: 578-83.
• Kassolis JD, Rosen PS, Reynolds MA. Alveolar ridge and sinus augmentation utilizing platelet- rich plasma in combination with freeze-dried bone allograft: case series. J Periodontol 2000; 71: 1654–61.
• Whitman DH, Berry RL, Green DM. Platelet gel: An autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. Journal of Oral and Maxillofacial Surgery 1997; 55: 1294-9.
• Lekovic V, Camargo PM, Weinlaender M, Vasilic N, Aleksic Z, Kenney EB. Effectiveness of a combination of platelet-rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans. Journal of Clinical Periodontology 2003; 30: 746-51.
• Froum SJ, Wallace SS, Tarnow DP, Cho SC. Effect of Platelet-Rich Plasma on Bone Growth and Osseointegration in Human Maxillary Sinus Grafts: Three Bilateral Case Reports. The International Journal of Periodontics and Restorative Dentistry 2002; 22: 45-53.
• Raghoebar GM, Schortinghuis J, Liem RS, Ruben JL, van der Wal JE, Vissink A. Does platelet- rich plasma promote remodeling of autologous bone grafts used for augmentation of the maxillary sinus floor? Clin Oral Implants Res 2005; 163: 349-56.
• Kaban LB, Pogrel MA, Perrot DH, editors. Complications in Oral and Maxillofacial Surgery. USA: W.B. Saundera Company: 1997
• Yildirim M, Spiekermann H, Biesterfeld S, Edelhoff D. Maxillary sinus augmentation using xenogenic bone substitute material Bio-Oss in combination with venous blood. A histologic and histomorphometric study in humans. Clin Oral Implants Res 2000; 11: 217-29.
• Wheeler SL. Sinus augmentation for dental implants: The use of alloplastic materials. Journal of Oral and Maxillofacial Surgery 1997; 55: 1287-93.
• Browaeys H, Bouvry P, Bruyn H. A literature review on biomaterials in sinus augmentation procedures. Clinical Implant Dentistry and Related Research 2007; 9: 166-77.
• Handschel J, Simonowska M, Naujoks C, Depprich RA, Ommerborn MA, Meyer U, Kübler NR. A histomorphometric meta-analysis of sinus elevation with various grafting materials. Head and Face Medicine 2009; 5: 1-10.
• Jung JH, Choi BH, Jeong SM, Li J, Lee SH, Lee HJ. A retrospective study of the effects on sinus complications of exposing dental implants to the maxillary sinus cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 103: 623-5.
• Lindhe J, Karring T, Lang NP, editors. Clinical Periodontology and Implant Dentistry. Oxford: Blackwell Publishing Ltd: 2003.
• Wiltfang J, Kloss FR, Kessler P, Nkenke E, Schultze-Mosgau S, Zimmermann R, Schlegel KA. Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. Clin Oral Implants Res 2004; 15: 187-93.
• Luo P, Trauner K. Calcium-Based Neutral and bioresorbable self-setting injectable bone putty. Berkeley Advanced Biomaterials, http:/sterling1surgica.com.
• Bodner L. Osseous regeneration in the jaws using demineralized allogenic bone implants. Journal Of Cranio-Maxillo-Facial Surgery 1998; 26: 116-20.
• Schmitt JM, Buck DC, Joh SP, Lynch SE, Hollinger JO. Comparison of porous bone mineral and biologically active glass in critical-sized defects. Journal Of Periodontology 1997; 68: 1043- 53.
• Aghaloo TL, Moy PK, Freymiller EG. Investigation of platelet-rich plasma in rabbit cranial defects: A pilot study. Journal of Oral and Maxillofacial Surgery 2002; 60: 1176-81.
• Velich N, Nemeth Z, Hrabak K, Suba Z, Szabo G. Repair of bony defect with combination biomaterials. Journal of Craniofacial Surgery 2004; 15: 11-5.
• Pieri F, Lucarelli E, Corinaldesi G, Fini M, Aldini NN, Giardino R, Donati D, Marchetti C. Effect of Mesenchymal Stem Cells and Platelet-Rich Plasma on the Healing of Standardized Bone Defects in the Alveolar Ridge: A Comparative Histomorphometric Study in Minipigs. Journal of Oral and Maxillofacial Surgery 2009; 67: 265-72.
• Pryor ME, Polimeni G, Koo KT, Hartman MJ, Gross H, April M, Safadi FF, Wikesjö UM. Analysis of rat calvaria defects implanted with a platelet-rich plasma preparation: histologic and histometric observations. Journal of Clinical Periodontology 2005; 32: 966-72.
• Kassolis JD, Reynolds M. Evaluation of the adjunctive benefits of platelet-rich plasma in subantral sinus augmentation. J Craniofac Surg 2005; 16: 280–7.
• Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85: 638-46.
• Kim ES, Park EJ, Choung PH. Platelet concentration and its effect on bone formation in calvarial defects: An experimental study in rabbits. The Journal of Prosthetic Dentistry 2001; 86: 428-33.
• Schlegel KA, Zimmermann R, Thorwarth M, Neukam FW, Klongnoi B, Nkenke E, Felszeghy E. Sinus floor elevation using autogenous bone or bone substitute combined with platelet-rich plasma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104: e15-e25.
• Raghoebar GM, Timmenga NM, Reintsema H, Stegenga B, Vissink A. Maxillary bone grafting for insertion of endosseous implants: results after 12–124 months. Clinical Oral Implants Research 2001; 12: 279-86.
• Jensen J, Sindet-Pedersen S, Oliver AJ. Varying treatment strategies for reconstruction of maxillary atrophy with implants: Results in 98 patients. Journal of Oral and Maxillofacial Surgery 1994; 52: 210-6.