Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus

Yıl 2016, Cilt: 8 Sayı: 1, 12 - 19, 15.06.2016

Elif Unsal Yusuf Nergiz Ercan Ayaz Murat Akkus Mehmet Sıddık Evsen

Öz

Background: The aim of this study was to compare of term placentas, which has gestational
diabetes mellitus and normal pregnant women in terms of immunolocalization of MMP-2 and
MMP-9.
Methods: Fifteen gestational diabetes mellitus patients and fifteen women without any systemic
disease of the placenta were collected. Fetal and maternal faces of the placentas, as well as
peripheral and central parts were examined for immunohistochemical investigation of MMP-2 and
MMP-9.Groups were evaluated through use of the SPSS 15.0 package program. P values ≤0.05
were considered statistically significant.
Results: MMP-2 reaction was weakly expressed in maternal and fetal surface, and no significant
difference between the two groups was observed. When MMP-9 expression was compared between
the groups, an increase in decidual cells of diabetic group and a decrease in syncytial nodes were
noticed. In fetal surface, a decrease in expression level was detected in chorionic villus
syncytiotrophoblasts, chorionic villus stroma, stem villus syncytiotrophoblasts, stem villous stroma
and chorionic plate.
Conclusion: Regarding our findings, MMP-9 plays a more active role than MMP-2 in gestational
diabetic placentas was concluded.

Anahtar Kelimeler

Full-term human placenta, gestational diabetes mellitus, MMP-2

Kaynakça

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