Yıl 2016, Cilt 8 , Sayı 1, Sayfalar 12 - 19 2016-06-15

Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus

Elif Unsal [1] , Yusuf Nergiz [2] , Ercan Ayaz [3] , Murat Akkus [4] , Mehmet Sıddık Evsen [5]


Background: The aim of this study was to compare of term placentas, which has gestational diabetes mellitus and normal pregnant women in terms of immunolocalization of MMP-2 and MMP-9. Methods: Fifteen gestational diabetes mellitus patients and fifteen women without any systemic disease of the placenta were collected. Fetal and maternal faces of the placentas, as well as peripheral and central parts were examined for immunohistochemical investigation of MMP-2 and MMP-9.Groups were evaluated through use of the SPSS 15.0 package program. P values ≤0.05 were considered statistically significant. Results: MMP-2 reaction was weakly expressed in maternal and fetal surface, and no significant difference between the two groups was observed. When MMP-9 expression was compared between the groups, an increase in decidual cells of diabetic group and a decrease in syncytial nodes were noticed. In fetal surface, a decrease in expression level was detected in chorionic villus syncytiotrophoblasts, chorionic villus stroma, stem villus syncytiotrophoblasts, stem villous stroma and chorionic plate. Conclusion: Regarding our findings, MMP-9 plays a more active role than MMP-2 in gestational diabetic placentas was concluded.

Full-term human placenta, gestational diabetes mellitus, MMP-2
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Birincil Dil en
Konular Genel ve Dahili Tıp
Yayımlanma Tarihi 15-06-2016
Bölüm Araştırma
Yazarlar

Yazar: Elif Unsal

Yazar: Yusuf Nergiz

Yazar: Ercan Ayaz

Yazar: Murat Akkus (Sorumlu Yazar)

Yazar: Mehmet Sıddık Evsen

Tarihler

Yayımlanma Tarihi : 15 Haziran 2016

Bibtex @araştırma makalesi { iamr510993, journal = {International Archives of Medical Research}, issn = {2146-6033}, address = {Dicle Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD, 21280, Diyarbakır-Türkiye}, publisher = {Veysi AKPOLAT}, year = {2016}, volume = {8}, pages = {12 - 19}, doi = {}, title = {Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus}, key = {cite}, author = {Unsal, Elif and Nergiz, Yusuf and Ayaz, Ercan and Akkus, Murat and Evsen, Mehmet Sıddık} }
APA Unsal, E , Nergiz, Y , Ayaz, E , Akkus, M , Evsen, M . (2016). Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus. International Archives of Medical Research , 8 (1) , 12-19 . Retrieved from https://dergipark.org.tr/tr/pub/iamr/issue/42428/510993
MLA Unsal, E , Nergiz, Y , Ayaz, E , Akkus, M , Evsen, M . "Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus". International Archives of Medical Research 8 (2016 ): 12-19 <https://dergipark.org.tr/tr/pub/iamr/issue/42428/510993>
Chicago Unsal, E , Nergiz, Y , Ayaz, E , Akkus, M , Evsen, M . "Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus". International Archives of Medical Research 8 (2016 ): 12-19
RIS TY - JOUR T1 - Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus AU - Elif Unsal , Yusuf Nergiz , Ercan Ayaz , Murat Akkus , Mehmet Sıddık Evsen Y1 - 2016 PY - 2016 N1 - DO - T2 - International Archives of Medical Research JF - Journal JO - JOR SP - 12 EP - 19 VL - 8 IS - 1 SN - 2146-6033- M3 - UR - Y2 - 2020 ER -
EndNote %0 International Archives of Medical Research Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus %A Elif Unsal , Yusuf Nergiz , Ercan Ayaz , Murat Akkus , Mehmet Sıddık Evsen %T Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus %D 2016 %J International Archives of Medical Research %P 2146-6033- %V 8 %N 1 %R %U
ISNAD Unsal, Elif , Nergiz, Yusuf , Ayaz, Ercan , Akkus, Murat , Evsen, Mehmet Sıddık . "Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus". International Archives of Medical Research 8 / 1 (Haziran 2016): 12-19 .
AMA Unsal E , Nergiz Y , Ayaz E , Akkus M , Evsen M . Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus. IAMR. 2016; 8(1): 12-19.
Vancouver Unsal E , Nergiz Y , Ayaz E , Akkus M , Evsen M . Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus. International Archives of Medical Research. 2016; 8(1): 19-12.